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University of Liverpool Molecular Biology PhD Projects, Programs & Scholarships

We have 41 University of Liverpool Molecular Biology PhD Projects, Programs & Scholarships

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  Characterisation of cell death mechanisms in cancer: protein interactions in p53/PERP-mediated apoptosis
  Prof L Paraoan, Dr I Prior
Applications accepted all year round
Apoptosis or programmed cell death is a tightly regulated intrinsic process of programmed cell death used by cells in all multicellular organisms, including humans, to control tissue homeostasis or to initiate their own death following malfunction or damage beyond repair.
  Characterization and functional analysis of a novel cancer-associated gene
  Dr JP de Magalhaes
Applications accepted all year round
In order to identify new candidate cancer-related genes, our lab developed a bioinformatics “guilt-by-association” method to identify and rank genes that are co-expressed with known cancer-related genes.
  Developing and applying computational methods to understand the genetics of ageing
  Dr JP de Magalhaes
Applications accepted all year round
Ageing is the chief biomedical challenge of the 21st century, yet it remains a major puzzle of biology. Although it is clear that the process of ageing has a strong genetic component, much work remains to elucidate how the genome regulates ageing.
  Developing co-culture systems to enable the modelling of interactions between cells of the synovial joint
  Dr S Tew
Applications accepted all year round
Synovial joints such as the knees and hips can be considered as multi tissue organs and crosstalk between the tissue types contributes strongly to the maintenance of their effective mechanical function.
  Development of treatment for Osteoarthritis by blocking metalloproteinases
  Prof G Bou-Gharios
Applications accepted all year round
MMP13 (collagenase 3) plays a vital role in the pathogenesis of osteoarthritis (OA) because MMP13 preferentially cleaves type II collagen, the main component of cartilage, and both MMP13 levels and enzymatic activity are enhanced in OA.
  Diabetic osteoarthritis : Investigating its causes and discovering interventions using tissue engineered human cartilage
  Dr JR Henstock
Applications accepted all year round
OVERVIEW. People with diabetes have more than twice the risk of developing osteoarthritis than the general population.
  Endocytosis in joint health and disease
  Dr K Yamamoto, Prof G Bou-Gharios
Applications accepted all year round
Osteoarthritis (OA) is the most prevalent age-related joint disorder that causes pain and disability. Over 8 million people suffer from OA in the UK alone, but there are no disease-modifying drugs available.
  Environmental regulation of mRNA decay in adult stem cells
  Dr S Tew
Applications accepted all year round
How cells control the rate at which specific mRNAs are destroyed critically influences gene expression levels and cell function.
  Functional and –omics investigation of neutrophil activation in rheumatoid arthritis
  Dr HL Wright, Prof RJ Moots, Dr M Phelan
Applications accepted all year round
Neutrophils are key effector cells in the pathogenesis of autoimmune diseases such as rheumatoid arthritis (RA), systemic lupus erythematosus and vasculitis.
  Identify differentially-expressed microRNAs in alkaptonuria patients
  Dr D Barraclough, Prof J A Gallagher, Prof L Ranganath
Applications accepted all year round
Alkaptonuria (AKU) is a serious autosomal recessive disease characterised by a multisystem involvement including stones (renal, prostate, gallbladder, salivary), ruptures (tendon, ligament, muscle), hearing impairment, aortic stenosis, and spondyloarthropathy.
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