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We have 31 University of Liverpool Molecular Biology PhD Projects, Programmes & Scholarships for Self-funded Students

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University of Liverpool Molecular Biology PhD Projects, Programmes & Scholarships for Self-funded Students

We have 31 University of Liverpool Molecular Biology PhD Projects, Programmes & Scholarships for Self-funded Students

University of Liverpool

We are curious problem solvers at the forefront of world-leading research. A hotbed of discovery and innovation, we're committed to addressing some of the toughest challenges in our society, both now and in the future. Join us in the search for answers by pursuing your PhD at the Original Redbrick.

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Probing Death Decisions from Morphogen Gradient Fields

University of Liverpool Department of Molecular and Clinical Cancer Medicine
Morphogen gradient scaling is one of the hottest fields in developmental biology at the moment. Scaling is fundamental, explaining how the machinery that controls pattern formation in development (the morphogens) can adapt, so that organs of different sizes show morphological structures which are proportioned. Read more
 Supervisor: Dr MM Merino
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Study of early pathological changes in calcified cartilage in osteoarthritis and alkaptonuria

University of Liverpool Institute of Ageing and Chronic Disease Department of Musculoskeletal Biology
We are seeking a motivated individual to work on this exciting project investigating the role that the calcified cartilage has in rare and common joint osteoarthritis, using novel approaches such as gene silencing and establishment of a 3D chondrocyte cell culture model. Read more
 Supervisor: Dr JH Hughes
 10 May 2024  PhD Research Project  Funded PhD Project (UK Students Only)
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Development of novel therapies for Hirschsprung’s Disease

University of Liverpool Faculty of Health and Life Science
As a PhD student, you'll be part of a groundbreaking project aiming to revolutionise the treatment landscape for Hirschsprung's Disease (HSCR). Read more
 Supervisors: Miss RH Harwood, Dr B Wilm, Miss SA Almond
 26 April 2024  PhD Research Project  Funded PhD Project (European/UK Students Only)
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Gaining mechanistic insights into Atrial Fibrillation: Bench to bedside approaches

University of Liverpool Department of Pharmacology and Therapeutics
Atrial fibrillation (AF) is a common arrhythmia with symptoms like irregular heart rate, palpitations, shortness of breath, tiredness, and dizziness. Read more
 Supervisor: Dr RB Burton
 1 July 2024  PhD Research Project  Self-Funded PhD Students Only
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Chromatin regulation of oncogenic transcription and replication stress: mechanism and functional implications in acute myeloid leukemia

University of Liverpool Institute of Systems, Molecular and Integrative Biology
This project focuses on the molecular mechanisms promoting acute myeloid leukaemia (AML), a disease of great unmet need. AML is an aggressive blood and bone marrow cancer characterized by abnormal proliferation and differentiation of myeloid cells. Read more
 Supervisors: Dr M Papamichos Chronakis, Prof D MacEwan, Dr A Kanhere
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Creation of cell lines modelling complex karyotype in B cell lymphomas using CRISPR/Cas9

University of Liverpool Institute of Systems, Molecular and Integrative Biology
Chronic lymphocytic leukaemia (CLL) and diffuse large B cell lymphoma (DLBCL) make up more than half of all the newly diagnosed cases of non-Hodgkin’s lymphoma (NHL), the 6th most common cancer in the UK. Read more
 Supervisors: Dr J Slupsky, Dr N Kalakonda, Dr M Glenn
 1 May 2024  PhD Research Project  Self-Funded PhD Students Only
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Protecting cells from mechanical stress: A novel role of cell-surface receptor LRP1 in extracellular matrix- nuclei communication.

University of Liverpool Institute of Ageing and Chronic Disease Department of Musculoskeletal Biology
Cellular adaptation to mechanical strain (mechano-adaptation) is increasingly understood to be conferred by Lamin intermediate filament proteins located within the nuclear lamina. Read more
 Supervisor: Dr K Yamamoto
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Translating protection of cell-surface receptor LRP1 into potential disease-modifying therapies for osteoarthritis.

University of Liverpool Institute of Ageing and Chronic Disease Department of Musculoskeletal Biology
Osteoarthritis (OA) causes pain and disability and is the most prevalent age-related joint disorder worldwide but there are no disease-modifying drugs available. Read more
 Supervisors: Dr K Yamamoto, Prof G Bou-Gharios
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Identifying age-related extracellular microenvironment in dental tissues

University of Liverpool Institute of Ageing and Chronic Disease Department of Musculoskeletal Biology
Periodontal disease is the sixth most globally prevalent age-related disease and a leading cause of tooth loss, significantly impacting quality of life and healthy ageing. Read more
 Supervisors: Dr K Yamamoto, Prof FJ Jarad
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Investigating the impact of galectin-ligand interaction on cancer cell resistance to chemotherapeutic treatment

University of Liverpool Institute of Life Course and Medical Sciences
Galectins are multifunctional carbohydrate-binding proteins that are expressed by many types of human cells. Changes of galectin expression commonly occur in cancer (e.g. Read more
 Supervisor: Prof LG Yu
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Investigating the regulation of neutrophil gene expression by intracellular signalling and small non-coding RNAs

University of Liverpool Institute of Life Course and Medical Sciences
Immune-mediated inflammatory diseases (IMID) such as rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) affect millions of people worldwide and cause debilitating and disabling musculoskeletal disease. Read more
 Supervisors: Dr HL Wright, Prof MJ Peffers
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Cardiovascular and Neuromuscular Functions around the Clock: Harnessing Protective Endogenous Mechanisms towards Smarter Design of Novel Therapies and Interventions

University of Liverpool Institute of Life Course and Medical Sciences
Optimal tissue and organ is essential for long-term health and quality of life. One such important regulator within the body is related to circadian rhythms, which control ~24h cycles in many physiological processes such as sleep/wake cycles, physical activity/rest cycles, drug metabolism and hormones. Read more
 Supervisor: Dr VPV Pekovic-Vaughan
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Investigating the role of neutrophil-mediated tissue damage in a model of lupus nephritis

University of Liverpool Institute of Life Course and Medical Sciences
Systemic lupus erythematosus (SLE) is a rare autoimmune disease that affects around 5 million people worldwide. It disproportionately affects women and is incurable. Read more
 Supervisors: Dr HL Wright, Dr D Wilkinson, Dr D Turner
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Using pre-clinical models of disease to define new targets to slow joint degeneration in osteoarthritis

University of Liverpool Institute of Life Course and Medical Sciences
The main overall aim of this project is to understand mechanisms of joint degeneration during osteoarthritis progression in order to define new targets for therapy. Read more
 Supervisor: Dr B Poulet
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Investigating the role of Aquaporins in age related diseases

University of Liverpool Institute of Life Course and Medical Sciences
Physical frailty, with its associated immobility and disability, is a major factor limiting independence among older people. A key contributor to frailty is a decline in muscle mass and strength (sarcopenia) and the burden of sarcopenia is substantial, with a cost to the NHS of ~£2.5bn/pa. Read more
 Supervisor: Dr C Staunton
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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