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We have 50 The University of Manchester Molecular Biology PhD Projects, Programmes & Scholarships

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The University of Manchester Molecular Biology PhD Projects, Programmes & Scholarships

We have 50 The University of Manchester Molecular Biology PhD Projects, Programmes & Scholarships

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Driving phenotypic plasticity and metastasis in small cell lung cancer

The University of Manchester Faculty of Biology, Medicine and Health
Small cell lung cancer (SCLC) is an aggressive malignancy with poor prognosis. Underlying this aggressiveness is intra-tumoural heterogeneity driven by phenotypic plasticity wherein tumour cells transition from a neuroendocrine (NE) to a non-neuroendocrine (non-NE) phenotype. Read more
 Supervisors: Prof A Malliri, Dr K Simpson, Prof C Dive
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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What is the interrelationship between cell mitosis and cell polarity during apical-basal polarisation of epithelial organs?

The University of Manchester Faculty of Biology, Medicine and Health
My group strives to uncover how mechanics and biochemical signalling work together to shape epithelial organs during development. Read more
 Supervisors: Dr C.B Buckley, Dr S Woolner
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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The impact of nutritional scavenging on host-pathogen interactions, antifungal efficacy and emergence of antifungal resistance

The University of Manchester Faculty of Biology, Medicine and Health
Infections caused by Aspergillus fumigatus (Af) cause more deaths globally than any other fungal disease. Over 20 million are affected annually with four million having life threatening invasive and chronic infections with high morbidity and mortality up to 90%. Read more
 Supervisors: Dr N.V.R Van Rhijn, Dr M Bromley
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Investigating WSB-1 as a prognostic marker and therapeutic target in urogenital cancers

The University of Manchester Faculty of Biology, Medicine and Health
Prostate cancer (PCa) is the commonest cancer diagnosed in men, with 5-year survival rates of 60% in those with advanced disease. Read more
 Supervisors: Dr IP Monteiro dos Santos Pires, Prof AC Choudhury
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Control of gene expression in embryonic development

The University of Manchester Faculty of Biology, Medicine and Health
The impressive range of anatomical variations observed in animals along their body axis is the result of distinct control mechanisms governing gene expression. Read more
 Supervisors: Prof N Bobola, Dr M Birket
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Investigating immune contributions to frontotemporal dementia and motor neuron disease

The University of Manchester Faculty of Biology, Medicine and Health
Frontotemporal dementia (FTD) is the 2nd most common form of dementia affecting younger people, with a typical age of onset in the mid-late 50s. Read more
 Supervisors: Dr SR Ryan, Prof D Brough
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Investigating the genetic basis of immunological overlap between inflammatory diseases

The University of Manchester Faculty of Biology, Medicine and Health
Genetic studies have identified numerous variants within the human genome associated with susceptibility to common complex inflammatory diseases, such as rheumatoid arthritis (RA) and ulcerative colitis (UC). Read more
 Supervisors: Mr P Martin, Prof S Eyre, Prof A Morris
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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The role of nuclear localisation of adhesion proteins in tumour growth and invasion

The University of Manchester Faculty of Biology, Medicine and Health
Overview. This project seeks to understand how tumour growth and invasion are controlled by the localisation of certain proteins in cancer cells. Read more
 Supervisors: Dr AB Byron, Dr K Finegan, Dr C Tournier
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Defining the molecular mechanisms of leukaemia chemotherapies

The University of Manchester Faculty of Biology, Medicine and Health
Chemotherapies are usually the backbone of cancer treatment for either curative or palliative patient care. Multiple therapies can be used for the same disease, with the choice of drug dependent on parameters such as the patient’s age and fitness. Read more
 Supervisors: Dr JK Knight, Dr K Batta, Dr D Wiseman
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Characterisation of PA protease from Micrococcus luteus as a novel approach to the management of eczema

The University of Manchester Faculty of Biology, Medicine and Health
The chronic inflammatory skin disease, eczema, now affects approximately 15% of the paediatric population of the Western world and is growing in prevalence. Read more
 Supervisors: Prof CN O'neill, Prof A McBain
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Chaperones and the response to protein misfolding stress

The University of Manchester Faculty of Biology, Medicine and Health
Misfolded proteins are usually refolded to their functional conformations or degraded by quality control mechanisms. When misfolded proteins evade quality control, they form aggregates that are sequestered to specific sites within cells. Read more
 Supervisors: Prof C M Grant, Prof M Ashe
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Investigating the interaction of La related proteins with colliding ribosomes

The University of Manchester Faculty of Biology, Medicine and Health
Translation of mRNA into proteins is a critical cellular biological process for all life. This requires ribosomes to act with an array of translation factors to decode mRNA sequences. Read more
 Supervisors: Prof G D Pavitt, Dr A Roseman
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Engineering Ice-Binding Proteins

The University of Manchester Department of Chemistry
Ice-binding proteins are produced by extremophiles to help them survive in the worlds coldest places. They have many potential applications, from the storage of cells/tissue to transport infrastructure. Read more
 Supervisor: Prof m Gibson
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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High-throughput biomaterials discovery

The University of Manchester Department of Chemistry
Polymer biomaterials have revolutionised a range of areas from drug delivery, to antimicrobials, to cellular cryopreservation. There are 1000’s of possible monomer combinations, molecular weights and architectures to be explored, and even small differences can dramatically change their properties. Read more
 Supervisor: Prof m Gibson
 Year round applications  PhD Research Project  Funded PhD Project (UK Students Only)
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Graphene oxide as growth factor carriers for meniscus tissue engineering

The University of Manchester Faculty of Biology, Medicine and Health
Damage to the meniscus of the knee leads to increased risk of osteoarthritis. Tissue engineering of a healthy meniscal fibrocartilage offers the opportunity to restore function. Read more
 Supervisors: Dr H Lu, Dr S Richardson, Prof P Xiao
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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