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University of Sheffield, MRC DiMeN Doctoral Training Partnership PhD Projects, Programs & Scholarships

We have 19 University of Sheffield, MRC DiMeN Doctoral Training Partnership PhD Projects, Programs & Scholarships

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  MRC DiMeN Doctoral Training Partnership: A personalised model of coronary artery blood flow
  Prof J Gunn, Dr P Morris
Application Deadline: 21 January 2019
Supervisors. Professor Julian Gunn https://www.sheffield.ac.uk/iicd/profiles/gunn. Dr Paul Morris https://www.sheffield.ac.uk/iicd/profiles/morris.
  MRC DiMeN Doctoral Training Partnership: Application of data science to inherited genetic variants of apoptosis genes and susceptibility to breast cancer
  Prof A Cox, Dr A Droop, Dr K Walters
Application Deadline: 21 January 2019
The identification of the breast and ovarian cancer genes BRCA1 and BRCA2 two decades ago has resulted in both improved risk assessment for patients and the use of PARP-inhibitors for treatment.
  MRC DiMeN Doctoral Training Partnership: Building integrated machine learning and genomic approaches to quantitate bone quality and fracture risk
  Prof M Wilkinson, Prof A Frangi, Dr E Zeggini
Application Deadline: 21 January 2019
This PhD Project would suit a candidate inspired by the prospect of participating in a multidisciplinary team in a project that sits at the interface between clinical medicine, computer science, and genomic medicine and who wishes to develop core skills in mathematics, statistics and computation.
  MRC DiMeN Doctoral Training Partnership: Evolution of antimicrobial resistance in Clostridium difficile
  Dr R Fagan, Prof M Brockhurst
Application Deadline: 21 January 2019
Background. Increasing resistance to antibiotics is one of the greatest health challenges facing humanity today. Clostridium difficile is the primary cause of antibiotic-associated infections in UK hospital and antibiotic-induced disruption of the gut microbiota is a prerequisite for infection.
  MRC DiMeN Doctoral Training Partnership: How do neurodegenerative mutations in kinesin-1 alter its structure, motility and cellular function?
  Dr A Twelvetrees, Dr K de Vos, Dr J.J.B. Cockburn
Application Deadline: 21 January 2019
This studentship is focused on understanding the molecular basis of neurodegeneration through the study of molecular motors, with the aim of opening up new avenues for intervention in disease.
  MRC DiMeN Doctoral Training Partnership: How do superbugs hide from the host? Understanding the mechanisms of innate immune evasion in the opportunistic pathogen Enterococcus faecalis
  Dr S Mesnage, Dr P Elks
Application Deadline: 21 January 2019
All enterococci produce a surface polysaccharide called the enterococcal polysaccharide antigen (EPA) that plays a key role during pathogenesis (Mistou et al., 2016).
  MRC DiMeN Doctoral Training Partnership: Mechanical activation of TGFbeta signaling in arterial disease
  Prof P Evans, Prof H Arthur
Application Deadline: 21 January 2019
Atherosclerosis, a disease of arteries that leads to angina, heart attack and stroke, develops at branches and bends of arteries that are exposed to disturbed patterns of blood flow.
  MRC DiMeN Doctoral Training Partnership: Optogenetic programming of inflammation - in vivo Opto-GPCR approaches in neutrophils
  Prof S Renshaw, Prof A Condliffe
Application Deadline: 21 January 2019
Diseases of inflammation contribute to the biggest health problems of the 21st century. Mutli-morbidity, the coincidence of multiple pathologies, is driven by processes such as inflammation and by inflammatory cells like neutrophils.
  MRC DiMeN Doctoral Training Partnership: Waking up to neurodegenerative diseases: development of an awake mouse preparation to investigate neurovascular dysfunction in ageing and Alzheimer’s disease
  Dr C Howarth, Dr J Berwick
Application Deadline: 21 January 2019
To maintain healthy brain function, local cerebral blood flow must be matched to neuronal metabolic demand through a dynamic relationship termed neurovascular coupling.
  MRC DiMeN Doctoral Training Partnership: Boosting immunity in chronic lung disease and antimicrobial resistant infection via the IL-33-ST2 axis
  Dr S Johnston, Prof S Renshaw, Dr A Humbles
Application Deadline: 21 January 2019
Macrophages are effector cells that directly kill microbes and regulatory cells that coordinate the wider immune response. Due to the complex nature of macrophage function, how their different roles are integrated during infection and inflammation is still poorly understood.
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