This PhD Project would suit a candidate inspired by the prospect of participating in a multidisciplinary team in a project that sits at the interface between clinical medicine, computer science, and genomic medicine and who wishes to develop core skills in mathematics, statistics and computation.
Background. Increasing resistance to antibiotics is one of the greatest health challenges facing humanity today. Clostridium difficile is the primary cause of antibiotic-associated infections in UK hospital and antibiotic-induced disruption of the gut microbiota is a prerequisite for infection.
Diseases of inflammation contribute to the biggest health problems of the 21st century. Mutli-morbidity, the coincidence of multiple pathologies, is driven by processes such as inflammation and by inflammatory cells like neutrophils.
Macrophages are effector cells that directly kill microbes and regulatory cells that coordinate the wider immune response. Due to the complex nature of macrophage function, how their different roles are integrated during infection and inflammation is still poorly understood.