More people die from fungal infections than from malaria, tuberculosis, or ‘superbugs’ such as MRSA. Candida species are an important group of human fungal pathogens causing over 400,000 life threatening infections per year.
Immune dysregulation and impaired gut mucosal barrier function are intimately linked features of two paediatric inflammatory gut disorders; namely graft-versus-host disease (GVHD) and necrotizing enterocolitis (NEC).
Background. This interdisciplinary project bridges world-leading labs with expertise in bacterial cell biology and infection. Novel therapies are needed to overcome increasing antibacterial resistance.