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University of Leeds, MRC DiMeN Doctoral Training Partnership PhD Projects, Programs & Scholarships

We have 16 University of Leeds, MRC DiMeN Doctoral Training Partnership PhD Projects, Programs & Scholarships

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  MRC DiMeN Doctoral Training Partnership: Breaking up the fight: Defining the spatial requirements for therapeutic modulation of signalling through FcγRIIa
  Dr j Robinson, Prof A Morgan, Prof A Goldman, Dr M E Webb
Application Deadline: 21 January 2019
Autoantibody-mediated inflammatory diseases are characterised by a proinflammatory feedback loop which leads to the destruction of tissues, prolonged pain, fatigue and subsequent reduction in life quality.
  MRC DiMeN Doctoral Training Partnership: Defining the link between glucose, miRNAs and extracellular vesicles in pregnancies complicated by maternal diabetes
  Prof K.A. Forbes, Prof E Scott, Dr N Simpson
Application Deadline: 21 January 2019
Maternal diabetes currently affects 1 in 20 pregnancies, making it one of the most common obstetric complications, and the incidence is set to rise.
  MRC DiMeN Doctoral Training Partnership: Discovering the neuronal signalling mechanism at the heart of cardiac arrhythmias
  Dr I Jayasinghe, Prof N Gamper, Prof E White
Application Deadline: 21 January 2019
Background. Cardiac arrhythmias are a leading cause of mortality and long-term morbidity worldwide. Over 25% of these originate in the heart’s electrically-autonomous (pacemaking) cells without a detectable heart attack.
  MRC DiMeN Doctoral Training Partnership: Functional Characterization of a Truncation Mutation Associated with Intellectual Disability
  Dr S Clapcote, Prof C Inglehearn, Dr M Ali
Application Deadline: 21 January 2019
Intellectual disability (ID) is a common neurodevelopmental disorder with an onset of cognitive impairment before the age of 18 years and is characterized by significant limitations in intellectual functioning and adaptive behaviour.
  MRC DiMeN Doctoral Training Partnership: Gene expression network analysis to identify candidate drivers of treatment resistance in glioblastoma multiforme
  Dr A Droop, Dr L Stead, Prof D R Westhead
Application Deadline: 21 January 2019
Glioblastoma (GBM) is an incurable brain cancer. Patients survive an average 14 months post-diagnosis, despite receiving surgery and intensive chemoradiation because 100% of tumours grow back.
  MRC DiMeN Doctoral Training Partnership: Harnessing T cells to target brain metastases
  Dr M Lorger, Dr R Salmond, Prof J Newton-Bishop
Application Deadline: 21 January 2019
An MRC-funded PhD student position is available to explore how T cells can be harnessed to enhance the efficacy of immune checkpoint inhibitors in melanoma brain metastases.
  MRC DiMeN Doctoral Training Partnership: Rationally Designed Oncolytic Reovirus-Based Immunotherapy for Hepatocellular Carcinoma
  Dr A Samson, Prof A Whitehouse, Dr C McKimmie
Application Deadline: 21 January 2019
Background. The incidence of hepatocellular carcinoma (HCC) in the UK has increased more than four-fold since 1990, and worldwide HCC is the second biggest cause of cancer-specific mortality.
  MRC DiMeN Doctoral Training Partnership: Understanding the genetics of melanoma by studying heritable risk factors
  Dr MM Iles, Prof T Bishop
Application Deadline: 21 January 2019
Background. Melanoma is the fifth most common cancer in the UK and its incidence has risen faster than any other common cancer - a five-fold increase since 1975.
  MRC DiMeN Doctoral Training Partnership: Addressing antimicrobial resistance (AMR): Affimers as therapeutic candidates and tools in antibacterial drug discovery
  Dr A O'Neill, Dr D Tomlinson
Application Deadline: 21 January 2019
The World Health Organization (WHO) has declared antimicrobial drug resistance (AMR) one of the greatest threats to human health, and it is predicted that this phenomenon will kill 10 million people annually by 2050 if not addressed.
  MRC DiMeN Doctoral Training Partnership: Capturing how Hsp90 prevents the formation of cell-disruptive toxic amyloid species by Cryo-EM in a C. elegans model for Alzheimer’s Disease
  Prof N A Ranson, Dr P van Oosten-Hawle
Application Deadline: 21 January 2019
How and when do amyloid proteins cause cellular toxicity and disease? And how can we prevent their formation?. Using a C.
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