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Neuroscience / Neurology (metabolism) PhD Projects, Programs & Scholarships

We have 25 Neuroscience / Neurology (metabolism) PhD Projects, Programs & Scholarships

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We have 25 Neuroscience / Neurology (metabolism) PhD Projects, Programs & Scholarships

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Rhythmic control of energy balance - to understand how our internal clocks regulate energy metabolism

24-hour rhythms are present in virtually all aspects of our behaviour and physiology. These rhythms are underpinned by circadian clocks that run throughout the body, and act within each tissue to orchestrate many organ functions and rhythmic activities (e.g. Read more

Mechanistic computational modelling of human glioblastoma metabolism

Glioblastoma is the most common and the most lethal malignant brain tumor. In vitro cell culture of glioma cells is essential for the discovery and development of novel anticancer treatments. Read more

A role for cholesterol metabolism in neurodevelopmental disorder

Microdeletions and duplications of the chromosome 15q11.2 region have been identified as a high penetrant risk copy number variance (CNV) to autism and schizophrenia. CYFIP1 (Cytoplasmic FMR1-interacting protein 1) is generally believed to be the causal risk gene in this CNV. Read more

Investigating the Mitochondrial Basis of Neuronal ageing

The exact cellular biological mechanisms of age related cognitive decline are poorly understood. Brain ageing is caused by accumulated damage that leads to neuronal dysfunction, tissue failure, and ultimately death. Read more

(BBSRC DTP) Defining the roles of mRNA methylation in circadian physiology and inflammation

Methylation is a pervasive biochemical modification targeting virtually all types of molecules in our cells. A key metabolic pathway called the “methyl cycle” synthesises S-adenosylmethionine (SAM), the methyl donor co-substrate used by over 200 substrate-specific methyltransferases described so far in humans. Read more

Self-funded BMS project: Ion channel signalling in cancer cells

Our cells constantly sense and transport ions present in their environment. From embryonic development to epilepsy to heart disease to cancer, our cells’ ability to respond to changes in the ionic microenvironment is essential for healthy ageing. Read more

Modelling the effect of ageing in silico and on Drosophila and mouse clock neurons

Supervisors. Dr James Hodge (University of Bristol) Second supervisor. Prof Krasimira Tsaneva-Atanasova (University of Exeter) Dr Mino Belle (University of Exeter), Prof Hugh Piggins (University of Bristol). Read more

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