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Neuroscience / Neurology (yeast) PhD Projects, Programs & Scholarships

We have 6 Neuroscience / Neurology (yeast) PhD Projects, Programs & Scholarships

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  Understanding the role that the RNA helicase UPF1 plays in sorting ribonucleoprotein (RNP) complexes and the mechanism by which this role of UPF1 might reduce cellular stress and cell degeneration.
  Research Group: BBSRC MIBTP
  Dr S Brogna
Application Deadline: 7 January 2020

Funding Type

PhD Type

This project’s specific objective is to study the molecular role(s) that the RNA helicase UPF1 plays in RNA processing. UPF1 is a key player in nonsense-mediated mRNA decay (NMD), it is universally conserved in eukaryotes and is essential to the development of many organisms [1].
  (MRC DTP) Developing a zebrafish model for a novel human neurodevelopmental disorder
  Prof G D Pavitt, Dr P Kasher, Dr S Banka
Application Deadline: 15 November 2019

Funding Type

PhD Type

Background. We have recently discovered a novel human disorder caused by mutations in the EIF5A1 gene resulting in developmental problems, small head size and craniofacial defects in children [1].
  Signalling pathways controlling protein degradation upon stress
  Dr A Rousseau
Application Deadline: 1 December 2019

Funding Type

PhD Type

Increasing evidence shows that alterations and mutations in the UPS give rise to various human diseases, such as cancer and neurodegenerative disorders.
  EASTBIO The role(s) of translation elongation factors in specific neuronal populations throughout the lifecourse
  Prof C Abbott, Prof I Stansfield
Application Deadline: 5 January 2020

Funding Type

PhD Type

Translation elongation factor eEF1A plays a pivotal role in the elongation step of protein synthesis, delivering the amino-acylated tRNA to the ribosome in a GTP dependent process facilitated by the eEF1B complex; eEF1A and eEF1B subunits together make up the eEF1 complex.
  Exploring the mitotic functions of ASPM in human brain size regulation
  Dr J Bond, Dr E E Morrison, Prof M Peckham
Applications accepted all year round

Funding Type

PhD Type

The increase in relative brain size is one of the most striking events in human evolution. To determine how human brain size is normally regulated we have investigated the cause of autosomal recessive primary microcephaly (MCPH), a congenital disorder of reduced brain size and associated mental retardation.
  Impaired stress response as a pathological mechanism in Myotonic Dystrophy Type 1 and related degenerative conditions
  Research Group: Biomedical Sciences Research Centre
  Dr J Sleeman
Application Deadline: 1 December 2019

Funding Type

PhD Type

Myotonic Dystrophy Type1 (DM1) is an incurable inherited multi-system disease that results in numerous symptoms including early cataract development, which can be the first sign of the disease.
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