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Neuroscience / Neurology (primary care) PhD Projects, Programs & Scholarships

We have 33 Neuroscience / Neurology (primary care) PhD Projects, Programs & Scholarships

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  A novel silk biomaterial-based combinational approach to enhance axonal regrowth after spinal cord injury
  Dr W Huang, Prof C McCaig, Dr P Seib
Application Deadline: 13 March 2020

Funding Type

PhD Type

Spinal cord injury causes permanent and incurable functional impairment below the injure site. No single therapy has ever been successful, so a combined approach is much more likely to succeed.
  The potential of elevating Epac2 to modulate glial activation and promote motor neuron regeneration in Amyotrophic Lateral Sclerosis
  Dr W Huang, Dr G S Bewick
Application Deadline: 13 March 2020

Funding Type

PhD Type

Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease characterised by the selective degeneration and death of motor neurons.
  What is the role of opioids in postoperative pain?
  Prof P Forget, Prof G Macfarlane
Application Deadline: 13 March 2020

Funding Type

PhD Type

The question seems trivial but remains largely unresolved. The present project aims to address the question using different approaches.
  What is the role of opioids in postoperative pain? Epidemiological and clinical perspectives
  Prof P Forget, Prof G Macfarlane
Application Deadline: 27 March 2020

Funding Type

PhD Type

The question seems trivial but remains largely unresolved. The present project aims to address the question using different approaches.
  Combining omega-3 docosahexaenoic acid and melatonin to manage spinal cord injury-induced central neuropathic pain.
  Dr W Huang, Prof H Galley
Application Deadline: 29 February 2020

Funding Type

PhD Type

About half of spinal injury patients develop neuropathic pain, which is driven by neuroinflammation, has no effective treatments, and impacts significantly on daily functioning.
  Determination of the function of inherited refractive error risk factor genes in the embryonic development of the eye.
  Prof L Erskine, Prof N Vargesson, Prof M Collinson
Application Deadline: 13 March 2020

Funding Type

PhD Type

Refractive errors, such as short-sightedness (myopia) and long-sightedness (hyperopia), are becoming epidemic, and in parts of southeast Asia around 80% of people have short-sight.
  Investigation of molecular mechanisms of Intellectual disability using human-brain organoids
  Dr E Kang, Dr D Berg
Application Deadline: 13 March 2020

Funding Type

PhD Type

Intellectual disability (ID) is a condition characterized by significant limitation in cognitive ability and adaptive behaviours with a disease onset before adulthood.
  The effect of anaesthetic neurotoxicity on the development of adult neural stem cells
  Dr D Berg, Dr E Kang
Application Deadline: 13 March 2020

Funding Type

PhD Type

Although most neurons in the mammalian brain are generated during development, certain areas possess the capacity to generate new neurons throughout life.
  Perceptual stability in Virtual Reality across the adult lifespan
  Dr P Warren, Dr R Champion
Applications accepted all year round

Funding Type

PhD Type

When we move, stationary parts of the world around us move on the retina. Of course, usually we correctly interpret this retinal motion as due to our own movement and not movement of the surrounding environment.
  The effects of Interleukin-1 primed mesenchymal stem cells on hypoxic-ischemic brain damage
  Dr E Pinteaux, Prof S Allan
Applications accepted all year round

Funding Type

PhD Type

Hypoxic-ischemic brain damage is one of the main causes of death and neurological disability after stroke worldwide.
  Characterising coordination difficulties in autism using computational techniques
  Dr E Gowen, Dr E Poliakoff, Dr A Casson
Applications accepted all year round

Funding Type

PhD Type

Autism is a life-long developmental condition that affects how a person communicates and interacts with people. ~80% of autistic individuals also have altered motor control such as less accurate eye-hand coordination and abnormal gait patterns, causing considerable problems with activities of daily living.
  Identifying the role of glycosaminoglycans and microglia in early pathology of mucopolysaccharide diseases
  Prof B BIgger, Dr R Holley, Prof S Flitsch
Applications accepted all year round

Funding Type

PhD Type

Mucopolysaccharidoses (MPS) are inherited metabolic disorders caused by the deficiency of specific lysosomal enzymes required for the catabolism of glycosaminoglycans (GAGs) where each MPS type lacks a specific enzyme resulting in the build-up of GAGs in all cells of the body.
  Investigating the link between amyloid-β oligomers, neuroinflammation and cognitive deficits in preclinical models for Alzheimer’s Disease
  Dr M Harte, Prof J Neill
Applications accepted all year round

Funding Type

PhD Type

Currently four out of the five pharmacological treatments used for Alzheimer’s disease (AD) are acetylcholinesterase inhibitors aimed at boosting the amount of acetylcholine in the brain, with the fifth being an N-methyl-D-aspartate (NMDA) receptor antagonist.
  Mechanisms of brain metastasis, Medical Sciences – funded MbyRes
  Dr J Whatmore
Application Deadline: 1 March 2020

Funding Type

PhD Type

Project Description. Secondary brain tumours i.e. brain metastases, are formed when cancer cells spread from their original site to the brain.
  Development of iPSCs from patients with Urofacial Syndrome for disease modelling
  Prof S J Kimber, Prof A Woolf
Applications accepted all year round

Funding Type

PhD Type

Peripheral neuropathies (PNs) affect 2% of the general population. Somatic PNs cause locomotor and sensory deficits, while autonomic PNs cause cardiac dysrhythmias and gastrointestinal and urinary bladder dysfunction.
  Impact of liver reduction diet, low calorie diet and bariatric surgery on hepatic health and cardiometabolic risk factors.
  Dr H Soran, Dr A Syed, Dr R Donn, Dr M Ferdousi
Applications accepted all year round

Funding Type

PhD Type

Obesity and its related co-morbidities, especially Type 2 Diabetes (T2DM), are a major source of disability and premature mortality from micro- and macro-vascular discease.
  Infants’ early understanding of word meaning
  Dr A Ferry, Prof A Theakston
Applications accepted all year round

Funding Type

PhD Type

While children begin to say their first words around 12 months of age, there is evidence that they start to understand the meaning of common words much earlier in development, suggesting that infants have already started to build a vocabulary.
  Investigating the incidence of falls and relationship to motor ability in autistic adults
  Dr E Gowen, Dr E Stanmore, Dr E Poliakoff
Applications accepted all year round

Funding Type

PhD Type

Autism is a life-long developmental condition that affects how a person communicates and interacts with people. In addition to these social symptoms, >70% of autistic individuals show signs of altered motor control such as less accurate eye-hand coordination, unstable balance and abnormal gait patterns.
  Small nerve fibre damage and sexual dysfunction in diabetes and obesity. A mechanistic assessment and effect of lipid modifying agents.
  Dr H Soran, Prof R Malik, Dr R Donn, Dr M Ferdousi
Applications accepted all year round

Funding Type

PhD Type

Diabetes and its complications represent a growing global health burden, affecting an estimated 366 million people worldwide.
  The effect of female sex hormones on hearing and tinnitus.
  Dr K Kluk
Applications accepted all year round

Funding Type

PhD Type

Sex hormones fluctuate in level in women, both during the lifespan and during the ovarian cycle. Recent research suggests that oestrogen is neuroprotective, and may affect auditory function.
  The Effects of Prior Conditioning on Susceptibility to Noise Damage in Young People
  Prof C Plack, Dr G Prendergast
Applications accepted all year round

Funding Type

PhD Type

There is increasing concern that young people are damaging their hearing through recreational activities such as attendance at live music events and use of personal listening devices.
  The representation of syntax in English and Mandarin Chinese
  Dr B Yao, Dr A Stewart
Applications accepted all year round

Funding Type

PhD Type

How syntax (language structure) is mentally represented in the brain is an ancient and challenging question in cognitive sciences.
  Use of highly multi-modal PET and MRI data as a predictive biomarker of the site of recurrence in neuro-oncology
  Dr R Hinz, Dr David Coope, Prof A Jackson
Applications accepted all year round

Funding Type

PhD Type

Primary brain tumour including glioblastoma (GBM), the most aggressive and most common form in adults, continue to have a socioeconomic impact that is disproportionate to the tumour frequency due to our inability to obtain a cure in the vast majority of adult sufferers.
  When more yields less: Understanding therapeutic gains according to lesion profile in chronic stroke aphasia.
  Dr A Woollams, Dr L Cloutman
Applications accepted all year round

Funding Type

PhD Type

Aphasia is a common consequence of stoke ultimately affecting one in five cases, with the most common residual difficulty being word finding difficulties, or anomia.
  Analysing the factors that regulate expression of blood-brain barrier drug transporter proteins
  Dr J L Penny, Dr C Demonacos
Applications accepted all year round

Funding Type

PhD Type

In order to treat diseases associated with the central nervous system (CNS), e.g. cancer, Parkinson’s disease, depression, it is essential for therapeutic drugs to be able to penetrate into the brain.
  Epigenetic mechanisms of behavioural, placental and cognitive impairment in a neurodevelopmental model for schizophrenia
  Dr R Hager, Prof J Neill, Dr J Glazier
Applications accepted all year round

Funding Type

PhD Type

A fundamental question in disease research is how stressors experienced during critical developmental periods influence the genesis or ‘programming’ of adult disease (Estes & McAllister 2016).
  Inflammation, the immune system and neurological disease
  Prof S Allan
Applications accepted all year round

Funding Type

PhD Type

Inflammation is now recognised as a key contributor to neuronal injury in both acute and chronic neurodegenerative disease. Many studies in this area have focussed on the post-injury inflammatory response and in particular on the role of specific cytokines in the central nervous system.
  Linear Poisson Modelling Independent Component Analysis of DESI Mass Spectral Tissue Images
  Dr A McMahon, Dr N Thacker
Applications accepted all year round

Funding Type

PhD Type

Desorption Electrospray Ionisation - Mass Spectrometry Imaging (DESI – IMS) allows mass spectra to be acquired from an. array of.
  Membrane protein misfolding and disease: quality control pathways
  Dr L Swanton, Prof P Woodman
Applications accepted all year round

Funding Type

PhD Type

Misfolded proteins represent a continuous threat to cell viability, and if allowed to accumulate, can disrupt cellular function and induce cell death.
  Molecular and cell-biological mechanisms mediating establishment of neuron polarity during development
  Dr R Das, Dr C Francavilla
Applications accepted all year round

Funding Type

PhD Type

Background. Cells undergoing neuronal differentiation in the embryonic spinal cord delaminate from the neuroepithelium, resulting in loss of apical cell polarity.
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