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University of Birmingham Neuroscience / Neurology PhD Projects, Programs & Scholarships

We have 12 University of Birmingham Neuroscience / Neurology PhD Projects, Programs & Scholarships

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  Regulation of autophagy in human embryonic stem cells and its therapeutic application in induced pluripotent stem cell-based disease models
  Dr S Sarkar
Applications accepted all year round

Funding Type

PhD Type

Project background. Regulation of proteostasis is critical for maintaining tissue homeostasis. Autophagy, a major intracellular degradation pathway essential for cellular and energy homeostasis, functions in the clearance of aggregation-prone proteins and damaged organelles.
  The importance of the DNA damage response in neurodegeneration
  Dr R Tuxworth
Applications accepted all year round

Funding Type

PhD Type

DNA damage occurs in early-stage neurodegenerative diseases. The response of neurons to the damage may contribute to disease progression by inducing senescence, cell-cycle and apoptosis.
  Analysis of pathogen determinants recognized by the hypervariable immune receptor Dscam
  Dr M Soller
Applications accepted all year round

Funding Type

PhD Type

Background. To mount an immune response, host organisms must first recognize the pathogen with which they are infected. The first line of defense against pathogen infection in animals is provided through the innate immune response.
  BBSRC MIBTP - Identification of pathways deregulating neuronal ELAV/Hu RNA binding proteins and alternative splicing in neurodegeneration
  Research Group: BBSRC MIBTP
  Dr M Soller, Dr M Tomlinson
Applications accepted all year round

Funding Type

PhD Type

ELAV/Hu proteins comprise a family of highly conserved neuronal RNA binding proteins important for the development of the nervous system and for neuronal functions.
  Eukaryotic gene expression: understanding the role of UPF1 in global mRNA processing and amyotrophic lateral sclerosis (ALS)
  Dr S Brogna
Applications accepted all year round

Funding Type

PhD Type

This project’s specific objective is to study the molecular role(s) that the RNA helicase UPF1 plays in RNA processing. UPF1 is a key player in nonsense-mediated mRNA decay (NMD), it is universally conserved in eukaryotes and is essential to the development of many organisms [1].
  Genetic and molecular mechanisms of brain structural plasticity and neurodegeneration
  Research Group: BBSRC MIBTP
  Dr A Hidalgo
Applications accepted all year round

Funding Type

PhD Type

The project will test the potential of a molecular mechanism that we recently discovered, in modulating brain structural plasticity versus neurodegeneration.
  Genetic and molecular mechanisms of nervous regeneration and repair
  Dr A Hidalgo
Applications accepted all year round

Funding Type

PhD Type

The project will aim to discover novel molecular mechanisms that could promote central nervous system regeneration. The focus will be on how neurons and glia interact to match their cell populations and functions, and on the regenerative potential of glial cells.
  Molecular genetic characterization of Drosophila reproductive behaviours for exploitation in insect population control
  Research Group: BBSRC MIBTP
  Dr M Soller
Applications accepted all year round

Funding Type

PhD Type

Female reproductive behaviours in most insects profoundly change after mating leading to rejection of courting males and induction of egg laying.
  mRNA epigenetics: Charaterization of a novel layer of gene regulation for essential brain functions
  Research Group: BBSRC MIBTP
  Dr M Soller, Dr PG Grzechnik
Applications accepted all year round

Funding Type

PhD Type

For over 40 years we know about modified nucleotides in mRNA, but the functions for these essential modifications are largely elusive.
  Neural basis underlying mating decisions in fruit flies
  Dr C Rezaval
Applications accepted all year round

Funding Type

PhD Type

Mate choice is an essential behavioural process with profound consequences in evolution. How do animals choose with whom to mate? How do they evaluate the features of a potential mate to maximise their reproductive success?.
  Perception in a dynamic multisensory world
  Prof U Noppeney
Applications accepted all year round

Funding Type

PhD Type

The aim of this project is to unravel the computations and neural mechanisms that enable us to perceive, understand and interact effectively with the dynamic multisensory world around us.
  Neural mechanisms underlying pain interference with motor learning in the human spinal cord
  Prof D Falla, Dr A Khatibi
Application Deadline: 30 November 2019

Funding Type

PhD Type

The project involves simultaneous imaging of the brain and spinal cord using Magnetic Resonance Imaging in Humans. The successful applicant will conduct a project evaluating changes in the connectivity between the brain and the spinal cord following the acquisition of new motor skills during the experience of pain.
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