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We have 36 Neuroscience (alzheimer) PhD Projects, Programmes & Scholarships

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Neuroscience (alzheimer) PhD Projects, Programmes & Scholarships

We have 36 Neuroscience (alzheimer) PhD Projects, Programmes & Scholarships

Investigating the links between β-amyloid, osteoporosis and frailty in Alzheimer’s disease

Background. Individuals with Alzheimer’s disease are more likely to suffer from osteoporosis (the loss of bone mass and strength) than age-matched individuals1, significantly contributing to the frailty associated with dementia. Read more

Normative modelling of resting-state EEG across the lifespan for application in the early diagnosis of neurodegenerative disorders including Alzheimer’s disease

With a rapidly aging human population worldwide, neurodegenerative diseases represent a pressing medical and societal concern. Given the increase in life expectancy, dementia is expected to affect almost 152 million people by 2050 (Alzheimer’s Disease International, 2018). Read more

Seeing inside the brain of Alzheimer’s disease by cryoET

The aim of this PhD project is to determine the in situ 3D molecular structures associated with AD to understand disease mechanisms and molecular pathways that can lead to the rational design of a mechanism-based therapy. Read more

Development of LA1011 for high affinity binding to Hsp90 for use towards healthy ageing in patients showing Alzheimer’s symptoms

  Research Group: Biochemistry
With 50 million global cases of Alzheimer’s disease (AD) and care costs of 1 trillion UK pounds (expected to triple by 2050), there is a pressing need to slow disease progression, sustain productive lives and reduce costs. Read more

Feeding microbes to protect the brain: does the gut microbiota mediate the risk-reducing effects of a healthy diet on Alzheimer’s disease?

Background. Ways of reducing the risk of developing Alzheimer’s disease (AD) and other dementias are critically needed, given the almost total lack of truly effective therapeutic options, even despite newer anti-amyloid drugs1. Read more

The breakdown of neurovascular coupling in the diseased state specifically Epilepsy and Alzheimer’s disease

Epilepsy is the most common neurological condition in the UK, affecting 1 – 2 % of the population. Epilepsies often involve only a small area of the brain - the epileptic focus – and the abnormal activity can propagate out from there. Read more

Systemic infections accelerate tau spreading by promoting glial activation

Alzheimer’s disease (AD) is a neurodegenerative disease, with a complex biology. In this PhD project, we aim to explore the cellular and molecular mechanisms underlying tau pathology. Read more

Identifying cognitive and biochemical changes underlying lifestyle risk factors for dementia

  Research Group: Pharmacology and Experimental Therapeutics
Dementia describes a group of age-associated conditions of which cognitive decline is a major feature. Alzheimer’s disease (AD) is the most common cause of dementia and is characterised by the onset of a gradual cognitive decline. Read more

MSc by Research: Nutrient-dependent regulation of microglia function and immune responses

Microglia are constantly sensing the brain environment for metabolic changes, damage and pathogenic invasion. Microglia are highly metabolically active, with activation in response to inflammatory stimulation increasing glycolytic demand. Read more

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