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Neuroscience (metabolism) PhD Projects, Programmes & Scholarships
We have 14 Neuroscience (metabolism) PhD Projects, Programmes & Scholarships
We have 14 Neuroscience (metabolism) PhD Projects, Programmes & Scholarships
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How GABA neurones in the DVC control glucose metabolism
The Dorsal Vagal Complex (DVC) of the brain is an important regulator of glucose metabolism and food intake. The Nucleus of the Solitary Tract (NTS) in the DVC senses insulin and triggers a neuronal relay to decrease hepatic glucose production (HPG) in rodents. Read more
Rhythmic control of energy balance - to understand how our internal clocks regulate energy metabolism
24-hour rhythms are present in virtually all aspects of our behaviour and physiology. These rhythms are underpinned by circadian clocks that run throughout the body, and act within each tissue to orchestrate many organ functions and rhythmic activities (e.g. Read more
Mechanistic computational modelling of human glioblastoma metabolism
Glioblastoma is the most common and the most lethal malignant brain tumor. In vitro cell culture of glioma cells is essential for the discovery and development of novel anticancer treatments. Read more
A role for cholesterol metabolism in neurodevelopmental disorder
Microdeletions and duplications of the chromosome 15q11.2 region have been identified as a high penetrant risk copy number variance (CNV) to autism and schizophrenia. CYFIP1 (Cytoplasmic FMR1-interacting protein 1) is generally believed to be the causal risk gene in this CNV. Read more
Determining brain glycosylation in ageing and Alzheimer’s disease
Research Group:
Pharmacology and Experimental Therapeutics
Increasing age is associated with lower levels of cognitive performance; concomitant with this is a decrease in brain glucose metabolism. Read more
The impact of gut microbiome and diet interplay on neurodegeneration
Neurodegenerative disorders such as Parkinson’s, Alzheimer’s or Huntington’s disease represent major health risks of ageing societies. Read more
Fully funded PhD position in neural mechanisms of gut-brain communication
Fully funded PhD position in neural mechanisms of gut-brain communication. Dr. Yu Fu’s lab, Division of Neurometabolism in Health and Diseases. Read more
Proteomic response to amyloid oligomers within a 3D Parkinson's disease model
Parkinson's disease (PD) is a progressive neurodegenerative condition that worsens as cells within the brain region known as the substantia nigra are lost over time. Read more
Mitochondria biogenesis and stress responses in health and disease
Maintenance of functional mitochondria is essential for life and an important therapeutic target in several diseases, including age-related neurodegenerative diseases. Read more
Imaging metabolic pathways in the brain using magnetic resonance spectroscopy - MPhil Scholarship
Methodologies for studying in vivo metabolic pathways in the brain have the potential to significantly improve diagnosis and treatment of multiple conditions including metastatic brain cancer, neurodegenerative disease or traumatic brain injury. 13C magnetic resonance spectroscopic imaging has shown significant potential for the non-invasive imaging of key metabolites in the brain. Read more
RNA biology in neurons and neurodegeneration
For cells to perform their biological functions, they need to able to adopt specific shapes and form functionally distinct subcellular compartments. Read more
Defining the physiological role and regulation of biological methylations
The regulation of gene expression and function operates at multiple levels. Metabolic pathways in the cell generate metabolites that directly affect DNA, RNA and proteins, regulating the expression and function of many genes, often feeding back on the very enzymes that catalysed their synthesis. Read more
Impact of maternal obesity on offspring adipogenesis
Obesity is the major health crisis of this generation. Thus, research into the mechanistic basis behind obesity is of paramount importance. Read more
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