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Neuroscience (metabolism) PhD Projects, Programmes & Scholarships

We have 14 Neuroscience (metabolism) PhD Projects, Programmes & Scholarships

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We have 14 Neuroscience (metabolism) PhD Projects, Programmes & Scholarships

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How GABA neurones in the DVC control glucose metabolism

The Dorsal Vagal Complex (DVC) of the brain is an important regulator of glucose metabolism and food intake. The Nucleus of the Solitary Tract (NTS) in the DVC senses insulin and triggers a neuronal relay to decrease hepatic glucose production (HPG) in rodents. Read more

Rhythmic control of energy balance - to understand how our internal clocks regulate energy metabolism

24-hour rhythms are present in virtually all aspects of our behaviour and physiology. These rhythms are underpinned by circadian clocks that run throughout the body, and act within each tissue to orchestrate many organ functions and rhythmic activities (e.g. Read more

Mechanistic computational modelling of human glioblastoma metabolism

Glioblastoma is the most common and the most lethal malignant brain tumor. In vitro cell culture of glioma cells is essential for the discovery and development of novel anticancer treatments. Read more

A role for cholesterol metabolism in neurodevelopmental disorder

Microdeletions and duplications of the chromosome 15q11.2 region have been identified as a high penetrant risk copy number variance (CNV) to autism and schizophrenia. CYFIP1 (Cytoplasmic FMR1-interacting protein 1) is generally believed to be the causal risk gene in this CNV. Read more

Determining brain glycosylation in ageing and Alzheimer’s disease

  Research Group: Pharmacology and Experimental Therapeutics
Increasing age is associated with lower levels of cognitive performance; concomitant with this is a decrease in brain glucose metabolism. Read more

Imaging metabolic pathways in the brain using magnetic resonance spectroscopy - MPhil Scholarship

Methodologies for studying in vivo metabolic pathways in the brain have the potential to significantly improve diagnosis and treatment of multiple conditions including metastatic brain cancer, neurodegenerative disease or traumatic brain injury. 13C magnetic resonance spectroscopic imaging has shown significant potential for the non-invasive imaging of key metabolites in the brain. Read more

Defining the physiological role and regulation of biological methylations

The regulation of gene expression and function operates at multiple levels. Metabolic pathways in the cell generate metabolites that directly affect DNA, RNA and proteins, regulating the expression and function of many genes, often feeding back on the very enzymes that catalysed their synthesis. Read more
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