BACKGROUND: . In the UK, 10 million people are 65 years or older which will rise to 19 million by 2050. Ageing is characterised by immune system deterioration, inflammation and declining skeletal muscle mass and function. Read more
Different tissues have unique genome-organisation patterns that fine-tune gene expression, e.g. by enhancing gene silencing through nuclear envelope (NE)-association. Read more
Skeletal muscle is a vital organ supporting many physiological processes, most notably physical activity. Muscle fatigue is a physiological event defined by the inability to sustain force, but can be improved following regular exercise training. Read more
Project Description. A cyclic interaction of the filamentous proteins actin and myosin is central to muscle contraction. How this essential interaction is regulated in normal and pathophysiological states is not fully understood. Read more
Smooth muscle is critically important in a range of functions, from maintaining blood pressure, to squeezing food through the gut and many more. Read more
Department of Anaesthesia and Intensive Care Medicine, Third Faculty of Medicine, Charles University. Our research group is currently seeking a highly motivated Ph.D. Read more
The human musculoskeletal system undergoes several age-related alterations, including reductions in muscle mass and function (termed ‘sarcopenia’). Read more
The World Health Organisation physical activity guidelines include recommendations for aerobic and muscle strengthening physical activity (MSPA). Read more
Chronic hypertension causes functional and anatomical rarefaction of the cerebral blood vessels and is the main risk factor after age for vascular dementia and stroke. Read more
Wearable technology has changed how we monitor health by allowing us to track detailed movement data over long periods, in real-time, and from anywhere. Read more
Muscle frailty is a serious condition and highly prevalent in the ageing community. It leads to accidental falls and injuries in aged individuals, and contributes significantly to the poor quality of life. Read more
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