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Molecular Biology PhD Projects, Programs & Scholarships in Nottingham

We have 17 Molecular Biology PhD Projects, Programs & Scholarships in Nottingham

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Nottingham  United Kingdom

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We have 17 Molecular Biology PhD Projects, Programs & Scholarships in Nottingham

Metabolic programming: Role of micronutrient (B12) deficiency and associated epigenetic marks

The global epidemic of childhood obesity is a major public health issue. Although current adverse lifestyle (nutrition and physical inactivity) contributes to obesity, a growing body of evidence links early life nutritional adversity to the development of obesity and metabolic disorders in children. Read more

Sequence variation and epigenomic mechanisms underlying human neuropsychiatric and neurodegenerative diseases

This is the decade of the ‘brain’ and this is also the decade of advancements in ‘genomic technologies’. This project aims to use cutting edge sequencing technologies and molecular approaches to understand susceptibility to human disorders of the brain. Read more

The development of Rab27 inhibitors for treatment of cancer cell invasion and proliferation

Rab27 small GTPases regulate movement and exocytosis of secretory granules in cell types including; melanocytes (melanosomes), T lymphocytes (lytic granules), granulocytes (azurophilic granules) and mast cells [1]. Read more

Natural toxins and their synthetic analogues as tools to study ion channels and as potential drugs and pesticides

The project will use a combination of electrophysiological techniques such as voltage-clamp and patch-clamp with molecular biology and protein expression to understand how natural toxins and their synthetic analogues act on ion channels in the nervous system. Read more

Defining the sequence requirements for neo-centromere function in the fission yeast Schizosaccharomyces pombe

Centromeres are the regions of the chromosome necessary for accurate segregation at cell division. They bind a complex set of proteins called the kinetochore which in turn tethers the chromosome to the microtubules of the spindle at cell division. Read more

Identification and characterisation of bacteriocins from environmental samples active against strains of Clostridium difficile.

Clostridiodes difficile is a cause of neonatal enteritis in livestock such as pigs, cattle and horses. Affected animals develop respiratory problems, abdominal distention and bloody diarrhoea leading to weight loss and in extreme cases mortality. Read more

Investigation of inflammatory joint milieu; a focus on immune-multipotent stem cells interactions.

Inflammation of the joints involves bone and cartilage damage. Different immune cells and stem cells contribute to this inflammatory milieu; however, more investigations are needed to understand the cross-talk between these cells. Read more

Investigation of bone healing milieu; a focus on multipotent stem cells.

Bone healing is a physiological process that involves different immune cells, stromal cells and mediators. The exact interactions between these cells and mediators are not entirely understood. Read more

Adaptation to environmental change in animals: ecology, evolution and genomics.

How are animals able to live in different environments, with different temperatures, energetic demands, diet, predators, parasites or pH? Thanks to advances in gene sequencing technology, we are in a remarkable period of discovery about the genomic basis of adaptation and how this depends on the intricacies of ecology and environment. Read more

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