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We have 19 Molecular Biology PhD Projects, Programmes & Scholarships in Nottingham

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Biological Sciences

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Nottingham  United Kingdom

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Molecular Biology PhD Projects, Programmes & Scholarships in Nottingham

We have 19 Molecular Biology PhD Projects, Programmes & Scholarships in Nottingham

Structural biology tools to investigate and target ubiquitin system proteases in cancer

Ubiquitination targets proteins for degradation and regulates virtually all cellular signalling pathways in eukaryotes. The human genome encodes over 50 ubiquitin specific proteases (USPs) that cleave ubiquitin from modified proteins to salvage them from proteasomal degradation. Read more

Metabolic programming: Role of micronutrient (B12) deficiency and associated epigenetic marks

The global epidemic of childhood obesity is a major public health issue. Although current adverse lifestyle (nutrition and physical inactivity) contributes to obesity, a growing body of evidence links early life nutritional adversity to the development of obesity and metabolic disorders in children. Read more

The role of calcium signalling in regulating of tumour cell behaviour

Metastasis is the major cause of mortality in human cancers, yet we know relatively little of the fundamental biology that underlies the important transition to invasive malignancy. Read more

How to build and maintain a 3-dimensional polarised epithelial sheet

We are interested in how cells maintain normal cell shape within an epithelium. Correct epithelial cell shape is essential to maintain tissue integrity and when deregulated can cause diseases such as malignant cancers, diabetes, inflammation, and aging. Read more

Structure and function of enzyme complexes involved in post-transcriptional gene regulation

Many proteins in human cells function as part of high molecular weight multi-subunit assemblies. The structure and function of such large molecular machines is often difficult to characterise due to their complexity, low abundance and structural dynamics. Read more

Exosome biogenesis and organelle trafficking in neurodegeneration.

Scientific summary. Intracellular transport pathways are fundamental for cell structure and function. Due to their longevity, complex morphology (long axonal and dendritic extensions) and requirement to maintain synaptic transmission, neurons are heavily dependent upon intracellular transport. Read more
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Exploring the potential for drug repurposing to enhance muscle mass and function in older adults.

Programme description. Loss of resilience describes enhanced vulnerability to, and impaired recovery from stress events when compared to a robust [youthful/healthy] state; and is commonly encountered with advancing age. Read more
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Optimising novel pre- and rehabilitation strategies to improve the physiological resilience of older surgical patients

PhD Description. In addition to rehabilitation, which has long been employed as method to enhance recovery from clinical stress events, there is burgeoning clinical and research interest in prehabilitation, an approach employed to prepare individuals for these events. Read more

Development and application of recombinant antibodies to map pathology-related changes in glycosaminoglycans on breast cancer cells

The School of Veterinary Medicine and Science (SVMS) undertakes a wide range of research from improving knowledge of fundamental biological processes, disease control including developing diagnostics and therapeutics, through to animal health and welfare, and population studies. Read more

Role of BTG1 and BTG2 in acute lymphocytic leukaemia and diffuse large B-cell lymphoma

Acute lymphocytic leukaemia (ALL) and diffuse large B-cell lymphoma (DLBCL) is often associated with small deletions of or point mutations in the highly related BTG1 or BTG2 genes. Read more

Discovery and profiling of small-molecule inhibitors of cellular nuclease enzymes

Nuclease enzymes are non-traditional drug targets that attract an increasing amount of interest as potential targets relevant for a variety of therapeutic areas including infection, cancer and bone disease. Read more

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