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We have 13 Molecular Biology PhD Projects, Programmes & Scholarships for Self-funded Students in Nottingham
Molecular Biology PhD Projects, Programmes & Scholarships for Self-funded Students in Nottingham
We have 13 Molecular Biology PhD Projects, Programmes & Scholarships for Self-funded Students in Nottingham
Structural biology tools to investigate and target ubiquitin system proteases in cancer
Ubiquitination targets proteins for degradation and regulates virtually all cellular signalling pathways in eukaryotes. The human genome encodes over 50 ubiquitin specific proteases (USPs) that cleave ubiquitin from modified proteins to salvage them from proteasomal degradation. Read more
Metabolic programming: Role of micronutrient (B12) deficiency and associated epigenetic marks
The global epidemic of childhood obesity is a major public health issue. Although current adverse lifestyle (nutrition and physical inactivity) contributes to obesity, a growing body of evidence links early life nutritional adversity to the development of obesity and metabolic disorders in children. Read more
Providing insights into the molecular understanding of heart development and the formation of congenital heart defects.
Our research aim is to understand how the heart develops and then how it goes wrong to give rise to congenital heart defects (CHDs). Read more
The role of calcium signalling in regulating of tumour cell behaviour
Metastasis is the major cause of mortality in human cancers, yet we know relatively little of the fundamental biology that underlies the important transition to invasive malignancy. Read more
How to build and maintain a 3-dimensional polarised epithelial sheet
We are interested in how cells maintain normal cell shape within an epithelium. Correct epithelial cell shape is essential to maintain tissue integrity and when deregulated can cause diseases such as malignant cancers, diabetes, inflammation, and aging. Read more
Structure and function of enzyme complexes involved in post-transcriptional gene regulation
Many proteins in human cells function as part of high molecular weight multi-subunit assemblies. The structure and function of such large molecular machines is often difficult to characterise due to their complexity, low abundance and structural dynamics. Read more
Exosome biogenesis and organelle trafficking in neurodegeneration.
Scientific summary. Intracellular transport pathways are fundamental for cell structure and function. Due to their longevity, complex morphology (long axonal and dendritic extensions) and requirement to maintain synaptic transmission, neurons are heavily dependent upon intracellular transport. Read more
The use of Drosophila melanogaster to identify novel therapeutic agents for Alzheimer’s disease
Since 2003, our understanding of the causes of Alzheimer’s disease (AD) have improved considerably, however, in that time only one new drug treatment has been approved. Read more
Role of BTG1 and BTG2 in acute lymphocytic leukaemia and diffuse large B-cell lymphoma
Acute lymphocytic leukaemia (ALL) and diffuse large B-cell lymphoma (DLBCL) is often associated with small deletions of or point mutations in the highly related BTG1 or BTG2 genes. Read more
Discovery and profiling of small-molecule inhibitors of cellular nuclease enzymes
Nuclease enzymes are non-traditional drug targets that attract an increasing amount of interest as potential targets relevant for a variety of therapeutic areas including infection, cancer and bone disease. Read more
Using genome engineering and bioinformatics to understand heterochromatin and centromere function in Schizosaccharomyces pombe and in cancer cells
Centromeres are the DNA sequences on eukaryotic chromosomes that mediate accurate chromosome segregation at both mitotic and meiotic cell divisions. Read more
The role of microtubule regulators in the progression of cancer: investigating the link between BRCA2 and depolymerising kinesins.
The mitotic kinesin KIF2C/MCAK regulates microtubule length in the mitotic spindle and plays a role in preventing chromosome-microtubule attachment errors. Read more
Saving the planet through carbon recycling: engineering bacterial capture of gasified waste for bioplastics production
Wider context. Climate change caused by the release of greenhouse gases from fossil fuels and through change of land use threatens life on our planet. Read more
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