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Pharmaceutical / Medicinal Chemistry PhD Projects, Programs & Scholarships in Nottingham

We have 6 Pharmaceutical / Medicinal Chemistry PhD Projects, Programs & Scholarships in Nottingham

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  EPSRC Industrial CASE PhD Studentship “DNP-enhanced Solid-state NMR Studies of Pharmaceuticals”
  Dr J J Titman
Applications accepted all year round
Solid-state nuclear magnetic resonance (NMR) is a powerful method for studying the molecular structure and dynamics of a broad range of systems from heterogeneous materials to biological molecules.
  Development of new serine protease inhibitors by optimisation of rationally designed covalent S1 fragments
  Dr M Stocks, Dr J Emsley
Application Deadline: 30 April 2019
The PhD studentship is an EPSRC Doctoral Training Partnership (https://epsrc.ukri.org/skills/students/dta/termsconds/) in collaboration with KalVista Pharmaceuticals a pharmaceutical company focused on the discovery, development, and commercialisation of small molecule protease inhibitors for diseases with significant unmet medical need.
  Biomolecular Science and Medicinal Chemistry Division PhD project: Proteases in the ubiquitin system – from molecular mechanisms to the development of novel inhibitors
  Dr I Dreveny
Applications accepted all year round
Ubiquitin is a posttranslational modifier that tags substrate proteins for degradation and regulates virtually all known cellular processes.
  Discovery and profiling of small-molecule inhibitors of cellular nuclease enzymes
  Dr G S Winkler
Applications accepted all year round
Nuclease enzymes are non-traditional drug targets that attract an increasing amount of interest as potential targets relevant for a variety of therapeutic areas including infection, cancer and bone disease.
  Cryo electron microscopy to study innate immune complexes on the surface of cancer cells
  Dr J Emsley
Application Deadline: 31 May 2019
Blood vessels of tumors carry specific markers on the cell surface. The innate immune system consisting of complement proteins and white blood cells (macrophages) are involved in the recognition and destruction of cancer cells.
  Prediction of drug release and absorption from oily depots and organogels
  Dr M Marlow, Dr P Gershkovich
Applications accepted all year round
For the last several decades parenteral long-acting oily depots for intramuscular injection (IM) and subcutaneous injection (SC), have been used in the treatment of schizophrenia and in hormone replacement therapy (e.g Fluphenazine decanoate in sesame oil , Prolixin Decanoate® (Bristol-Myers Squibb).
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