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Organic Chemistry (structural biology) PhD Projects, Programs & Scholarships

We have 24 Organic Chemistry (structural biology) PhD Projects, Programs & Scholarships

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  Harnessing Computational and Structural Biology Platforms for Drug Discovery
  Dr D Cole, Dr N Tatum, Dr E Pohl
Application Deadline: 6 March 2020

Funding Type

PhD Type

The spread of low-cost computing and development of data analysis techniques, such as machine learning, promise to improve our understanding of biological disease mechanisms and the design and prioritisation of new pharmaceutical molecules.
  PhD in Chemical Biology -- Neuropeptide Research -- University of Vienna
  Prof M Muttenthaler
Applications accepted all year round

Funding Type

PhD Type

Neuropeptides are key mediators in many biological functions and understanding their interaction with target proteins is fundamental to unravel the underlying mechanism of diseases.
  Development of chemical biology tools to study mammalian O-mannosylation pathways
  Dr L Willems, Prof G Davies
Applications accepted all year round

Funding Type

PhD Type

The field of chemical biology aims to design and synthesize chemical tools (such as inhibitors, substrate mimics, or enzyme probes) to answer fundamental questions in biology.
  CRISPR Screen Multiplexing for Uncharacterised Region Function (SMURF)
  Dr L Prendergast, Dr M Martin, Prof S Wedge
Application Deadline: 6 March 2020

Funding Type

PhD Type

CRISPR-Cas9 screening utilising tiling-sgRNA design across genes, permits functional evaluation of protein domains and precise mapping of critical amino acids.
  The chemical glycobiology of carbohydrate metabolism
  Prof R Field, Prof S Flitsch
Applications accepted all year round

Funding Type

PhD Type

Carbohydrates are widespread in nature and fulfil many important biological functions. However, the biology of carbohydrates is much less well explored than that of nucleic acids and proteins.
  MRC DTP 4 Year PhD Programme: Targeting E3 ubiquitin ligases with small molecules
  Prof A Ciulli, Dr S Virdee
Application Deadline: 13 March 2020

Funding Type

PhD Type

This project is offered as part of the University of Dundee 4-year MRC DTP Programme “Quantitative and Interdisciplinary approaches to biomedical science”.
  Harnessing Reactive Phosphorylating Agents for Peptide Bioconjugations
  Dr D Hodgson, Prof I Hickson, Prof M Noble
Application Deadline: 6 March 2020

Funding Type

PhD Type

Protein-protein interactions (PPIs) are central to signalling processes associated with many diseases. Disruption of PPI-mediated pathways offers new therapeutic targets, with great potential for selective, potent inhibition because they can mimic native protein structures.
  Harnessing Reactive Phosphorylating Agents for Peptide Bioconjugations - EPSRC Centre for Doctoral Training (CDT) in Molecular Sciences for Medicine (MoSMed)
  Dr D Hodgson
Application Deadline: 6 March 2020

Funding Type

PhD Type

Overview. Protein-protein interactions (PPIs) are central to signalling processes associated with many diseases. Disruption of PPI-mediated pathways offers new therapeutic targets, with great potential for selective, potent inhibition because they can mimic native protein structures.
  Biocatalytic Approaches for the Synthesis of Therapeutic Oligonucleotides
  Dr S Lovelock, Dr A Green
Application Deadline: 27 February 2020

Funding Type

PhD Type

Therapeutic oligonucleotides are short DNA analogues which selectively bind to target mRNA through Watson-Crick base pairing to regulate the production of disease related proteins.
  Unravelling the mysteries of retinoid signalling
  Dr E Pohl, Prof J Endicott
Application Deadline: 6 March 2020

Funding Type

PhD Type

Retinoids, such as all-trans-retinoic acid (ATRA), are a class of endogenous molecules derived from Vitamin A. These compounds control a wide range of cellular processes in chordates, including differentiation, proliferation and apoptosis, by binding one or more of related transcriptional receptors in the cell nucleus.
  PhD inChemistry - Protein structural mimics through chemical ligation
  Dr D Thomson
Application Deadline: 1 July 2020

Funding Type

PhD Type

This project targets the interface between chemistry and biology. Chemistry has provided many reactions that can be used to join complex molecules together, these ‘ligation’ reactions are useful, but often leave behind chemical functionality that serves no purpose other than to connect fragments together.
  Carbohydrate analysis for biomedical applications.
  Dr S Allman
Applications accepted all year round

Funding Type

PhD Type

Changes in the patterns of carbohydrates produced by the cell can provide insights into disease states, revealing perturbations and differences in cellular metabolic processes.
  PhD in Chemistry – Molecular design, chemical synthesis and structural characterisation of novel peptides and peptidomimetics
  Dr A Jamieson
Application Deadline: 31 August 2020

Funding Type

PhD Type

Peptides derived from natural sources are useful lead compounds to develop therapeutics. The structural diversity of naturally occurring peptides covers a large section of chemical space that sits between more traditional small molecules (.
  Cell-permeable cyclic peptide library generation for target-based screening
  Prof A Kawamura, Prof M Waring, Dr SL Cobb
Application Deadline: 6 March 2020

Funding Type

PhD Type

Peptides hold enormous promise as chemical tools for selective intervention in biology. They can target chemical space distinct from that of small molecules and their chemical diversity provides high specificity and affinity or target binding.
  From Fragment-screening to Fragment-growing - new strategies for drug discovery
  Dr E Pohl, Dr C Cano
Application Deadline: 6 March 2020

Funding Type

PhD Type

Type-2 diabetes represents a major health problem in particular in industrialised countries and although many cases may be preventable by lifestyle changes, numbers are steadily rising.
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