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Organic Chemistry (natural) PhD Projects, Programs & Scholarships

We have 48 Organic Chemistry (natural) PhD Projects, Programs & Scholarships

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  Genome mining of novel antimicrobial natural products from new bacterial strains
  Dr H Deng, Prof M Jaspars
Applications accepted all year round

Funding Type

PhD Type

Antimicrobial resistance (AMR) is rising to dangerously high levels in all parts of the world. In Europe alone, drug-resistant bacteria are estimated to cause 25,000 deaths annually and cost more than US$1.5 billion every year in healthcare expenses and productivity losses.
  Exploring the synthesis and biological value of natural product-inspired compounds
  Dr D Foley
Applications accepted all year round

Funding Type

PhD Type

Key words. natural products; organic synthesis; medicinal chemistry; drug discovery. Motivated international and New Zealand-based candidates are invited to apply for a University of Canterbury Doctoral Scholarship to investigate the synthesis and biological value of natural product-inspired compound collections.
  Development of new catalytic methods for the efficient construction of natural product-inspired 3D scaffolds
  Prof C J Hayes
Applications accepted all year round

Funding Type

PhD Type

This PhD project aims to develop new catalytic synthetic methods for the efficient construction of natural product-inspired 3D scaffolds.
  Discovery of novel pharmaceuticals from marine and desert microorganisms
  Prof M Jaspars, Dr R Ebel
Applications accepted all year round

Funding Type

PhD Type

Microorganisms from extreme environments such as the deep seas, cold seas and hyper arid deserts have been shown to produce a range of complex natural products with high biological activity.
  PhD in Chemistry- Total Synthesis of Bioactive Marine Natural Products
  Prof S Clark
Application Deadline: 27 March 2020

Funding Type

PhD Type

Suitably qualified and highly motivated candidates are invited to apply for a fully-funded 3.5-year PhD studentship (EPSRC DTA) which will commence on 1st October 2020 under the direction of Professor Stephen Clark in the School of Chemistry at the University of Glasgow.
  Elucidating plant alkaloid biosynthesis
  Dr B R Lichman, Dr W Unsworth
Application Deadline: 30 June 2020

Funding Type

PhD Type

Plants are capable of forming complex natural products from simple starting materials. Many of these natural products are bioactive, but access is limited as they are difficult to synthesise using organic chemistry and are present in small quantities in the natural source.
  Artificial Intelligence and Machine Learning for Natural Sciences
  Prof P Friederich
Applications accepted all year round

Funding Type

PhD Type

The recently founded AIMat group at the Karlsruhe Institute of Technology (KIT) is searching for motivated students with a above-average Masters degree in computer science or (computational) natural sciences.
  Novel synthetic approaches to antimicrobial natural products and investigations of their bioactivity
  Prof A Malkov
Applications accepted all year round

Funding Type

PhD Type

The aim of the project is to develop new highly effective anti-tubercular agents. Previously, it has been established that terpenes isolated from marine organisms possess a number of important antibacterial properties.
  Fully-funded PhD positions in several natural sciences & engineering disciplines

Funding Type

PhD Type

Join an internationally renowned scientific community with the Hector FellowPhD program. PhD students benefit not only from the experience of the program, but also from the network of Hector Fellows.
  PhD in Chemistry - Tissue-like hydrogels based on Carbon Nitride
  Dr B V K J Schmidt
Application Deadline: 10 March 2020

Funding Type

PhD Type

Bright, highly motivated candidates are invited to apply for a fully funded 3.5 year PhD position in the School of Chemistry, available to commence on 1st October 2020 in the Schmidt research group at the University of Glasgow.
  Unravelling the mysteries of retinoid signalling
  Dr E Pohl, Prof J Endicott
Application Deadline: 6 March 2020

Funding Type

PhD Type

Retinoids, such as all-trans-retinoic acid (ATRA), are a class of endogenous molecules derived from Vitamin A. These compounds control a wide range of cellular processes in chordates, including differentiation, proliferation and apoptosis, by binding one or more of related transcriptional receptors in the cell nucleus.
  Synthesis of Lamellarin alkaloids using a photoredox initiated cyclisation cascade
  Dr M Kimber
Application Deadline: 31 July 2020

Funding Type

PhD Type

Our research group focuses on the synthesis of heterocycles, particularly using singlet oxygen and activation of enamides and allenamides.
  Expanding the Genetic Code of a Synthetic Yeast
  Prof P Cai, Dr A Green
Applications accepted all year round

Funding Type

PhD Type

The proposed project aims to develop an efficient yeast-based protein expression platform with an expanded genetic code. The standard genetic code of natural organisms comprises 20 canonical amino acids.
  Targeting the cancer – approaches to the design and synthesis of new anti-cancer agents (SEARCEYMU20SCIPVC)
  Prof M Searcey, Dr A Beekman
Application Deadline: 17 April 2020

Funding Type

PhD Type

The last few years have seen the introduction to the clinic of antibody-drug conjugates or ADCs that have revolutionised the treatment of some cancers.1 They enable the targeting of highly potent molecules to their site of action- the tumour cell – so that side effects should be diminished as off target effects are reduced.
  Investigating mechanism, reactivity and catalysis in organic, supramolecular and biological chemistry
  Prof NH Williams
Applications accepted all year round

Funding Type

PhD Type

We are interested in designing and synthesising organic molecules to investigate the basis of catalysis, and to apply these principles to designing our own, artificial catalysts.
  Investigating mechanism, reactivity and catalysis in organic, supramolecular and biological chemistry
  Prof NH Williams
Applications accepted all year round

Funding Type

PhD Type

We are interested in designing and synthesising organic molecules to investigate the basis of catalysis, and to apply these principles to designing our own, artificial catalysts.
  PhD in Enantioselective Catalysis and mechanistic studies
  Dr A Smith
Applications accepted all year round

Funding Type

PhD Type

Our research is currently directed towards developing catalytic methods for the promotion of a range of synthetic transformations with varying applications in enantioselective catalysis.
  Studies on the Total Synthesis of Streptosetin A
  Dr P Clarke
Applications accepted all year round

Funding Type

PhD Type

Streptosetin A has anti-tumour activity and contains a decalin ring system and a tetramic acid group, which are non-trivial to construct.
  Chemo-enzymatic Synthesis and Potential Applications of Novel Heterocyclic Alkaloids
  Dr H Deng, Dr L Trembleau
Applications accepted all year round

Funding Type

PhD Type

Antimicrobial resistance (AMR) is rising to dangerously high levels in all parts of the world. In Europe alone, drug-resistant bacteria are estimated to cause 25,000 deaths annually and cost more than US$1.5 billion every year in healthcare expenses and productivity losses.
  Developing an enzymatic toolbox to make complex modified peptides
  Prof M Jaspars, Dr W Houssen, Dr L Trembleau
Applications accepted all year round

Funding Type

PhD Type

The pharmaceutical industry has identified a major gap in its portfolio. On the one hand, they are excellent at discovering small molecules that act via a lock and key type mechanism.
  Biogas upgrading by means of cyclic adsorption processes
  Dr C Fernandez-Martin, Dr D Dionisi
Applications accepted all year round

Funding Type

PhD Type

Global warming is one of the most worldwide current challenges facing humanity, a direct consequence of the increasing CO2 emissions generated from the combustion of fossil fuels.
  Cell-permeable cyclic peptide library generation for target-based screening
  Prof A Kawamura, Prof M Waring, Dr SL Cobb
Application Deadline: 6 March 2020

Funding Type

PhD Type

Peptides hold enormous promise as chemical tools for selective intervention in biology. They can target chemical space distinct from that of small molecules and their chemical diversity provides high specificity and affinity or target binding.
  Design and synthesis of DNA encoded libraries of unnatural peptides to discover specific chemical probes
  Prof M Waring, Prof A Kawamura, Prof M Noble, Dr SL Cobb
Application Deadline: 6 March 2020

Funding Type

PhD Type

Peptides of allow the rapid identification of protein ligands from huge libraries of genetically encoded peptides, including cyclic peptides.
  Molecular cancer therapeutics activated by radioisotope-generated Cerenkov radiation
  Dr J Knight, Dr R Pal, Dr K Rankin
Application Deadline: 6 March 2020

Funding Type

PhD Type

The beta-particles emitted by certain medical radioisotopes can travel faster than light through the human body. When this happens, a photonic boom - comparable to a sonic boom – releases energy in the form of Cerenkov radiation which has a characteristic blue glow.
  Developing New Tools for the Chemical Diversification of Peptide Scaffolds
  Dr SL Cobb, Prof A Kawamura, Prof M Waring
Application Deadline: 6 March 2020

Funding Type

PhD Type

Peptides are useful leads for the development of new drugs against a wide range of diseases. They occupy the chemical space between small molecules and antibodies and as such they can reach or selectively inhibit drug targets that these other molecules cannot.
  Diffusion Ordered Spectroscopy NMR for the Rapid Identification of Medicinal Plants
  Dr JM Peron, Dr A Le Gresley
Applications accepted all year round

Funding Type

PhD Type

Diffusion Ordered Spectroscopy (DOSY) is a nuclear magnetic resonance (NMR) technique that is used to analyse mixtures.[1–3] Put simply, NMR signals that overlap in 1D NMR spectra are separated in 2D DOSY spectra according to molecular size and those that belong to the same component align as they are governed by the same diffusion coefficient.
  Organic/Medicinal Chemistry and Molecular Biology
  Dr S Coote, Dr S Allinson
Application Deadline: 10 March 2020

Funding Type

PhD Type

A fully funded 3.5-year PhD studentship in the area of organic/medicinal chemistry and molecular biology is available in the Department of Natural Sciences, Lancaster University, commencing in October 2020.
  Activation of Carbon Dioxide to the synthesis of Biologically Relevant Molecules
  Dr B Buckley
Application Deadline: 31 July 2020

Funding Type

PhD Type

This project will look at the selective modification of compounds to deliver new/non-natural amino acids/peptides. The approach will use a new carboxylation process developed in our group.
  Synthesis of ribonucleosides using biocatalytic cascades
  Prof N Turner, Prof S Flitsch
Applications accepted all year round

Funding Type

PhD Type

Background – Current state of the art for the synthesis of Anti-Sense Oligonucleotides employs solid phase synthesis. The ASOs are assembled from individual ribonucleotides which themselves are often requiring complicated multistep routes to prepare.
  Synthetic and Mechanistic Studies into Enzymatic Degradation of Waste Plastics
  Dr L Wong, Dr C F Blanford
Applications accepted all year round

Funding Type

PhD Type

Plastics are a broad range of solid polymeric materials that have found widespread application as industrial components and consumer goods.
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