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We have 76 Organic Chemistry PhD Projects, Programmes & Scholarships for Non-European Students
Organic Chemistry PhD Projects, Programmes & Scholarships for Non-European Students
We have 76 Organic Chemistry PhD Projects, Programmes & Scholarships for Non-European Students
(MRC DTP) Targetting Extracellular Glycans for antimicrobial therapy and diagnostics
Most drugs have intracellular targets, such as enzyme or transporter inhibitors. Whilst successful, this approach relies on the design of molecules which are not only effective ‘binders’ but are sufficiently membrane permeable. Read more
Developing Direct-to-Biology for Molecular Glue Discovery
Targeted protein degradation (TPD) is a novel and rapidly emerging drug discovery paradigm. One frequently pursued TPD approach focuses on the development of molecular glue degraders (MGDs), which provide an unprecedented opportunity to target undruggable oncoproteins. Read more
Lightning and the Chemical Origin of Life
What are the early steps in the chemical origin of life on Earth, prior to the existence of complex organic molecules and biology? Could Earth have relied… Read more
Electrified Chemical Synthesis for a Zero-Carbon Future
Synthetic nitrogen fertilizer produced by the Haber-Bosch process provides food security for half of the global population (4 billion people) today. Read more
Structural biology: A gas channel in vitamin B6 biosynthetic enzymes
Study of gas channels in proteins. You will study gas channeling and structural dynamics in bacterial (tuberculosis), malarial, and plant enzymes involved in Vitamin B6 biosynthesis. Read more
P25. The catalytic synthesis of sulfonamide and sulfonimidamide building blocks from simple feedstocks (CSHP CDT)
Sulfur derived functional groups are found in medicinal agents used to treat to broad range of indications. Sulfonamides are most common group, featuring in >10% of medicines. Read more
P24. Metal catalysis for the sustainable synthesis of pharmaceutically relevant heterocycles (CSHP CDT)
Functionalised heterocycles remain the cornerstone of medicinal chemistry programmes, and in particular, heterocycles linked to a second heterocycle or other aromatic group, feature prominently. Read more
P23. Polymers From Carbon Dioxide: Using Precision Catalysis to Control Polymer Properties (CSHP CDT)
Polymer manufacturing is already responsible for 1.6 Gt CO2 equiv. emissions annually, recent academic study reveals that replacing petrochemical raw materials with biomass, carbon dioxide and waste polymers can help to drive down these emissions enabling net zero targets. Read more
P22. CO2 and Bio-derived Oxygenated Polymers to Reduce Adhesives Carbon Footprint (CSHP CDT)
Adhesives play a critical role in many technologies from construction, transportation, electronics to consumer goods. There are growing environmental concerns, legislation and customer pressure to deliver more sustainable adhesives and to ensure they maximise recycling of other components. Read more
P21. Radical polar crossover from the triplet state (CSHP CDT)
New reaction manifolds are valuable for the synthesis of complex molecules. This project will focus on the development of radical-polar crossover reactions by employing visible light mediated energy transfer catalysis to generate complex three-dimensional heterocyclic scaffolds. Read more
P19. Combatting Antimicrobial Resistance (CSHP CDT)
Resistance to pharmaceuticals, including anti-infectives and cancer drugs, and agrochemicals is a major global health problem. As highlighted by the 2016 O’Neill report, the situation with current antibiotics is perilous. Read more
P18. Synthesis of Aryl-fused Bicyclo[3.1.1]heptanes (BCHeps) and Validation as Heterobiaryl Bioisosteres (CSHP CDT)
While naphthalene and equivalent heterobiaryl rings are often encountered in drugs, candidates and lead molecules, they can be susceptible to cytochrome P450-mediated metabolism and exhibit flat, sp2-rich structures and are almost invariably derived from fossil fuel sources, limiting their current and future utility. Read more
P15. Sustainable Hydrogen Borrowing Catalysis with Earth Abundant Metals (CSHP CDT)
While hydrogen borrowing (HB) catalysis offers an attractive route for the construction of C-C bonds using alcohols and ketones, current methods rely upon expensive precious metal catalysts. Read more
P14. Next generation antibiotic siderophores (CSHP CDT)
This project will develop next generation synthetic siderophores - small molecule high affinity iron receptors used by bacteria to accumulate iron. Read more
P13. Micellar organo-catalysis in water using earth abundant main group elements (CSHP CDT)
This project will explore methods to use earth abundant, Lewis acidic main group catalysts to catalyse organic transformations in water by exploiting micellar confinement. Read more