We invite applications for DPhil (a PhD at other universities) and MSc courses in Physiology, Anatomy and Genetics at the University of Oxford. Read more
While most animal species are usually comprised of separate male and female individuals, plant mating systems are far more diverse, with multiple independent origins of separate sexes (dioecy) from ancestral hermaphroditic state. Read more
A major hurdle for moving genome-targeted therapies such as antisense oligonucleotides (ASO) and CRISPR-editing into routine care is the health technology assessment (HTA) process and demonstrating cost-effectiveness to agencies such as NICE. Read more
The increasing availability of whole-genome sequencing (WGS) data, from programmes including 100,000 Genomes Project (100kGP) and the NHS Genomic Medicine Service, is enabling genetic diagnoses to be made for many families with rare genetic disorders. Read more
Plasmids are extrachromosomal elements in bacteria that confer virulence and resistance against antimicrobials. In the host adapted pathogens, Shigella and Neisseria gonorrhoeae, plasmids have established long evolutionary links with the bacterial species. Read more
Centromeres are the structural regions of chromatin that serve as a platform for the kinetochore machinery assembly, hence essential for accurate chromosome segregation during cell division. Read more
As males age, they exhibit declines in fecundity and produce lower quality offspring compared to younger males. While age-related declines in male fitness (senescence) are well-documented across many species, the mechanisms driving these changes remain poorly understood. Read more
Enhancers are short DNA regulatory elements that regulate tissue-specific gene expression by recruiting the transcriptional machinery onto promoters of target genes. Read more
Our central hypothesis is that engineered extracellular vesicles (EVs) can serve as innovative and non-immunogenic delivery mechanisms for in vivo genome editing of hematopoietic stem cells (HSCs). Read more
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