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We have 33 Other PhD Projects, Programmes & Scholarships in Oxford
Other PhD Projects, Programmes & Scholarships in Oxford
We have 33 Other PhD Projects, Programmes & Scholarships in Oxford
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How can trials and real-world evidence provide the best possible evidence on the benefits and risks of implantable devices? (NDORMS 2024/10)
Medical devices and surgical innovation have been under-researched in the past, leading to safety concerns and numerous high-profile scandals, such as those related to metal-on-metal hip replacements and surgical mesh. Read more
Single Particle Liquid Biopsy Analysis for Acute Myocardial Infarction
Commercial partner: SPARTA Biodiscovery Ltd. Project background and description. Extracellular Vesicles (EVs) are nano-sized membrane vesicles with a phospholipid bilayer and are released by most cells, heathy and diseased, into biological fluids. Read more
Towards equity in medicine with big health data, epidemiology, and artificial intelligence (NDORMS 2024/13)
The Covid-19 pandemic has highlighted inequalities in healthcare systems around the world. Inequalities based on ethnicity are of concern because most of our understanding of many diseases comes from White or Caucasian populations whose risk factors, disease prevalence and incidence can differ from other ethnic groups. Read more
Evaluating the efficacy of interventions for idiopathic toe-walking in children. Research proposal for prospective DPhil student (3-year project) (NDORMS 2024/8)
Idiopathic toe walking (ITW) is a common, exclusionary diagnosis to describe children with minimal or no heel contact to the ground during walking. Read more
Sex differences and the interplay of androgens and oestrogens in the modulation of human immune responses. (NDORMS 2024/6)
The immunological response to foreign antigens is distinct in men and women, as was so clearly demonstrated during the recent Covid-19 pandemic. Read more
The Department of Oncology at the University of Oxford
The Department of Oncology employs multidisciplinary approaches from physics, biology, chemistry and mathematical modelling to investigate DNA biology and epigenetics, cell and environmental biology of tumour tissue, and both systemic and local immunological responses in cancer. Read more
Developing translatable TetraVecta-enabled allogeneic regulatory T cell therapy
Commercial partner: Oxford Biomedica (UK) Ltd (OXB). Pathological immune activation is a hallmark of several diseases from autoimmunity to solid organ transplant rejection. Read more
High-throughput characterisation of the functional antibody epitope landscape of surface protein targets to guide vaccine and biologic design
Commercial partner: DJS Antibodies. Understanding the nature of antibody-antigen interactions and how these relate to functional outcomes is vital in guiding the rational design of next-generation vaccines and monoclonal antibody (mAb) therapeutics. Read more
Unravelling the effects of mitochondrial replacement therapy on mtDNA transmission
Commercial partner: Juno Genetics. Normal oocytes contain ~100,000 copies of mtDNA, which are effectively identical. Patients with mtDNA disease may harbour both mutant and normal mtDNA (heteroplasmy). Read more
Artificial Intelligence for climate-health mitigation and adaptation (NDORMS 2024/14)
The World Health Organisation recognises climate change as the greatest threat to human health. It affects social and environmental determinants of health and compounds underlying intersectional health inequalities. Read more
Scaphoid fractures: Identifying the cellular targets and key molecular pathways for improved repair outcomes (NDORMS 2024/12)
This full-time DPhil post at the Botnar Institute will use cutting edge laboratory and computational methods to interrogate the mechanisms underlying failed repair following scaphoid fracture. Read more
Identification and modification of the cellular and molecular mechanisms underlying unsuccessful knee replacements for osteoarthritis (NDORMS 2024/11)
Knee osteoarthritis (OA) is the most common form of arthritis, affecting 5.4 million people in the UK. It is characterised by loss of cartilage and inflammation and fibrosis of the synovial tissue that surrounds the joint. Read more
Real world evidence in the study of different subtypes of breast, lung, and prostate cancers: phenotyping, synthetic arm trials, and target trial emulation (NDORMS 2024/9)
Precision medicine in oncology is changing the prognosis of numerous cancers. However, the identification of very specific and rare cancer subtypes is leading to challenges in the recruitment of enough subjects for randomised controlled trials. Read more
Psychometric sensitivity analyses for clinical trials and observational studies that use patient-reported outcome measures (NDORMS 2024/7)
Patient-reported outcome measures (PROMs) are questionnaires used to assess various aspects of a person's health. They have become a common tool for measuring outcomes in randomised controlled trials (RCTs) and observational studies. Read more
