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We have 4 Pathology (dementia) PhD Projects, Programmes & Scholarships

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Pathology (dementia) PhD Projects, Programmes & Scholarships

We have 4 Pathology (dementia) PhD Projects, Programmes & Scholarships

Investigations into the protective actions of CBD in the early synaptic deficits in dementia.

Accumulation of hyper-phosphorylated tau is a key event in Alzheimer’s disease (AD). Aberrant changes in tau cause synaptic abnormalities and cognitive deficits in early AD. Read more

Examining the dysfunction of DNA damage repair in synucleinopathies

DNA damage is an emerging stressor implicated in the pathogenesis of neurodegenerative diseases. Our recent research within post-mortem dementia with Lewy body brain tissue has highlighted the dysregulation of several DNA damage repair pathways, alongside the occurrence of a novel nuclear alpha-synuclein pathology. Read more

Investigating Lysosomal Dysfunction in Ageing and Neurodegeneration

Lysosomes are key cellular organelles that degrade and recycle macromolecules, act as signalling hubs and are implicated in many diseases including Parkinson’s disease (PD) and Alzheimer’s dementia (AD) where old age is a major risk factor. Read more

Normative modelling of resting-state EEG across the lifespan for application in the early diagnosis of neurodegenerative disorders including Alzheimer’s disease

With a rapidly aging human population worldwide, neurodegenerative diseases represent a pressing medical and societal concern. Given the increase in life expectancy, dementia is expected to affect almost 152 million people by 2050 (Alzheimer’s Disease International, 2018). Read more
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