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We have 17 Pathology (public) PhD Projects, Programmes & Scholarships

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Pathology (public) PhD Projects, Programmes & Scholarships

We have 17 Pathology (public) PhD Projects, Programmes & Scholarships

Molecular mechanisms of pacemaker (sinus node) dysfunction in ageing, heart failure and athletes

  Research Group: Chemistry and Biosciences
The heart’s pacemaker, the sinus node, initiates the action potential that causes the heart to beat, and the atrioventricular node conducts the action potential from the atria to the ventricles, the pumping chambers of the heart. Read more

Unravelling the Intricacies of Stress Hormone Regulation

Project Overview. The proopiomelanocortin (POMC) pathway is a crucial signaling cascade involved in regulating various physiological processes, including our response to stress, metabolism, immune function, and pigmentation. Read more

Characterisation of adrenoceptor and muscarinic receptor subtypes coupled to potassium channels in chondrocytes from bovine cartilage

  Research Group: Chemistry and Biosciences
Several outward potassium currents have been identified in bovine chondrocytes (review Mobasheri et al. 2012). These include ATP-sensitive and a Calcium-activated potassium currents (Sanches & Lopez-Zapata, 2011). Read more

Investigation of the extracellular matrix as a regulator of Parkinson’s progression

  Research Group: Chemistry and Biosciences
Parkinson’s is the 2nd most common neurodegenerative disease, affecting around 1 in 20 people aged over 65. In the UK, the number of affected people is set to rise by 50% over the next 50 years due to ageing populations. Read more

An investigation on the association of high risk human papillomavirus (HPV) types with colonic adenomata and adenocarcinomas: a UK population based study

This PhD studentship invites application for a study “investigating the association between high risk human papillomavirus (HPV) types and colonic adenomata and adenocarcinomas in a UK population”.  Colorectal cancer (CRC) is an important public health problem worldwide occupying most frequent causes of cancer-related mortality. Read more

Mendelian Randomisation for mediation analysis with multiple mediators: theory and applications

Rationale. Many of an individual’s traits are observationally associated with their health outcomes. Understanding the relationships between these factors is critical to effective public health intervention. Read more

How do hormones regulate memory?

Deficiencies of thyroid hormone are common throughout the globe. Adult-onset hypothyroidism is prevalent in around 8-10% of the population and is associated with reproductive disorders, anxiety, depression and impairment of memory. Read more

The role of selective and novel biomarkers and their correlation with clinical outcome measures, pre and post-surgical treatment of benign and malignant disorders of the prostate

The Maelor Academic Unit of Medical & Surgical Sciences (MAUMSS) is a novel initiative by the Betsi Cadwaladr University Health Board (BCUHB), and is designed to encourage and support research within the Health Board and to promote academic activity, basic science and clinical research across North Wales (UK) and beyond. Read more

Low density lipoprotein oxidation and atherosclerosis

Project overview. The research in Professor David Leake’s group is concerned with atherosclerosis, the underlying cause of coronary heart disease and thrombotic strokes. Read more

Examining the mechanisms that cause cardiovascular disease by studying the heart or adipose tissue

Heart failure has a serious impact on our society and once diagnosed has a poor survival rate. In the United Kingdom, there are about 1.5 million people living with the after-effects of a heart attack. Read more

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