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We have 14 Pathology (brain) PhD Projects, Programmes & Scholarships

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Pathology (brain) PhD Projects, Programmes & Scholarships

We have 14 Pathology (brain) PhD Projects, Programmes & Scholarships

Identifying secreted biomarkers in brain cancer

Stage IV brain cancer or glioblastoma (GBM) poses a major challenge with only 5 FDA approved chemotherapeutic drugs available for treatment. Read more

Investigating local invasion in primary and secondary brain tumours

Brain tumours are highly invasive and carry a poor prognosis. Secondary brain tumours or brain metastases (BM) are the most common tumours found in the brain affecting up to one third of patients with solid organ cancer. Read more

Systemic infections accelerate tau spreading by promoting glial activation

Alzheimer’s disease (AD) is a neurodegenerative disease, with a complex biology. In this PhD project, we aim to explore the cellular and molecular mechanisms underlying tau pathology. Read more

Investigation of the extracellular matrix as a regulator of Parkinson’s progression

  Research Group: Chemistry and Biosciences
Parkinson’s is the 2nd most common neurodegenerative disease, affecting around 1 in 20 people aged over 65. In the UK, the number of affected people is set to rise by 50% over the next 50 years due to ageing populations. Read more

How do hormones regulate memory?

Deficiencies of thyroid hormone are common throughout the globe. Adult-onset hypothyroidism is prevalent in around 8-10% of the population and is associated with reproductive disorders, anxiety, depression and impairment of memory. Read more

Learning and Memory in the response to recurrent hypoglycaemia in diabetes

Recurrent hypoglycaemia has both acute and chronic consequences and is greatly feared by people with type 1 diabetes. Work from our laboratory over the last few years has revealed that the brain adaptation to recurrent hypoglycaemia in type 1 diabetes represents a specialised form of memory called habituation. Read more

Vascularisation of tumour organoids for mechanistic and drug development

Gliomas such as are the most common form of brain tumour, a subset Glioblastoma (GBM) are devastating adult brain cancer with high rates of recurrence and treatment resistance. Read more

Examining the dysfunction of DNA damage repair in synucleinopathies

DNA damage is an emerging stressor implicated in the pathogenesis of neurodegenerative diseases. Our recent research within post-mortem dementia with Lewy body brain tissue has highlighted the dysregulation of several DNA damage repair pathways, alongside the occurrence of a novel nuclear alpha-synuclein pathology. Read more

Role of the endosomal pathway in regulating sleep and circadian rhythms

Ageing and many neurodegenerative disorders are characterised by a progressive loss of neurons in particular brain regions leading to behavioural changes including cognitive decline, sleep disruption and circadian dysregulation. Read more
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