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Pathology (career) PhD Projects, Programs & Scholarships

We have 46 Pathology (career) PhD Projects, Programs & Scholarships

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  Build your expertise in tissue regeneration and repair at The University of Edinburgh

Funding Type

PhD Type

Our MSc by Research in Regenerative Medicine and Tissue is a one-year, full-time, on-campus Masters programme structured around two laboratory-based research projects.
  A multiple modality approach for targeting treatment-resistant ovarian cancer
  Dr E. Sanij, Prof R. Pearson
Applications accepted all year round

Funding Type

PhD Type

High-grade serous ovarian cancer (HGSOC) accounts for 70% of ovarian cancer (OvCa) deaths and its five-year survival rate is 43%.
  Cellular cross-talk at the perivascular niche and the blood brain barrier
  Prof B Hogan
Applications accepted all year round

Funding Type

PhD Type

Much research on vasculature has focussed on the endothelial cells that line functional vessels, however the milieu of cells that surround vessels (mural cells) play important and under-appreciated roles in homeostasis and disease.
  Computational simulation of tumour formation and progression
  Dr D. Goode
Applications accepted all year round

Funding Type

PhD Type

Tumours comprise a complex mix of related but distinct cellular subpopulations that both compete and complement one another. These dynamics strongly influence how and when a tumour forms as well as its response to therapy, however there are hard to observe directly.
  Fishing for metabolic clues: Role of the Hippo/Yap pathway in reprogramming metabolism in liver cancer
  Dr A. Cox
Applications accepted all year round

Funding Type

PhD Type

The Hippo/Yap pathway is an evolutionarily conserved cascade that plays a fundamental role in governing organ size control, stem cell homeostasis and cancer.
  Fueling chemotherapy resistance in triple-negative breast cancer
  Dr K Brown
Applications accepted all year round

Funding Type

PhD Type

Triple-negative breast cancer (TNBC) is a molecularly heterogeneous group of diseases defined by the lack of estrogen receptor (ER), progesterone receptor (PR) and absence of human epidermal growth factor receptor-2 (HER2) amplification.
  Genomic determinants of long-term survival in ovarian cancer
  Research Group: Cancer Genetics & Genomics Laboratory
  Prof D. Bowtell, Dr D Garsed
Applications accepted all year round

Funding Type

PhD Type

High-grade serous ovarian cancer is an aggressive disease in which only ~30% of women survive 5 years or more. Despite a poor prognosis, a subset of patients are highly responsive to chemotherapy, and some become long-term survivors (>10 years survival).
  How does amino acid metabolism affect tumour growth?
  Dr L. Cheng
Applications accepted all year round

Funding Type

PhD Type

The effect of diet on tumour growth is hotly debated but poorly characterized. Due to the heterogeneous nature of the tumours, dietary studies in patients with varied genetic background often led to inconclusive outcome.
  Inhibition of PRMT5 as a cancer therapy
  Dr K. Sheppard
Applications accepted all year round

Funding Type

PhD Type

Targeted therapy has had profound impact on outcomes for cancer patients.
  Investigating the requirements of pro-inflammatory signaling in skin and head & neck Squamous Cell Carcinomas
  Dr C Darido
Applications accepted all year round

Funding Type

PhD Type

Squamous cell carcinomas (SCC) are amongst the most common cancer types afflicting man. SCCs most frequently arise from stratified squamous epithelia such as the epidermis or the mucosae of the head and neck.
  Mechanisms of regulating gene expression via selective mRNA transport
  Dr V Wickramasinghe, Prof R. Pearson
Applications accepted all year round

Funding Type

PhD Type

A critical step in the gene expression pathway that is altered in cancer is nuclear export of mRNA. We have demonstrated that mRNA export is not constitutive, but highly selective and can regulate distinct biological processes through poorly understood mechanisms.
  Metabolic Reprogramming in Liver Cancer: delineating the role of reactive oxygen species (ROS) in tumour development
  Prof T. Tiganis
Applications accepted all year round

Funding Type

PhD Type

The Tiganis Laboratory is seeking a highly enthusiastic student to conduct research in cancer metabolism and obesity-associated liver cancer.
  Metabolic rewiring in liver cancer: Role of oxidative stress and the Nrf2 pathway
  Dr A. Cox
Applications accepted all year round

Funding Type

PhD Type

Many of the major risks factors for developing liver cancer such as alcohol, obesity, smoking and toxin exposure share in common a role for oxidative stress.
  mRNA translation reprogramming and metabolic re-wiring in response to ribosome-targeted therapies
  Prof R. Pearson, Dr J Kang
Applications accepted all year round

Funding Type

PhD Type

Increased synthesis and activity of ribosomes are associated with oncogenesis downstream of the major oncogenes including MYC, RAS and PI3K.
  Predicting the development of oral cancer
  Dr C Darido
Applications accepted all year round

Funding Type

PhD Type

Human head and neck cancer is a devastating disease with poor survival rates.
  RNA Methylation in normal and malignant blood development
  Dr L. Kats
Applications accepted all year round

Funding Type

PhD Type

As is the case with DNA and histones, RNA can also be modified and indeed more than 100 chemical groups that decorate all four canonical RNA nucleotides have been described.
  Role of the tumour microenvironment in gastric cancer
  Dr A. Boussioutas, Dr R. Busuttil
Applications accepted all year round

Funding Type

PhD Type

Gastric cancer (GC) is the fourth most common cancer globally and 7th in incidence in Australia. It has a poor survival rate which can be attributed to the advanced stage at diagnosis in most patients.
  Targeting IDH mutations in acute myeloid leukaemia
  Dr L. Kats
Applications accepted all year round

Funding Type

PhD Type

Acute Myeloid Leukaemia (AML) is an aggressive disease with poor prognosis and development of novel treatment options is urgently needed.
  Testing the function of immune suppressive cytokines and cells in bone metastasis
  Assoc Prof B Parker
Applications accepted all year round

Funding Type

PhD Type

Bone metastasis is a common occurrence in breast and prostate cancer that leads to patient morbidity and, in many cases, mortality.
  The Hippo pathway and Yap1 in vascular growth control in development and disease
  Prof B Hogan, Dr A. Cox
Applications accepted all year round

Funding Type

PhD Type

Lymphatic vessels play roles in the drainage of tissue fluid, trafficking of immune cells and the metastatic spread of cancer.
  The role of oesophageal submucosal glands in epithelial homeostasis and the development of Barrett’s oesophagus
  Research Group: Cancer Biology & Surgical Oncology Laboratory
  Prof W. Phillips, Dr N. Clemons
Applications accepted all year round

Funding Type

PhD Type

Barrett’s oesophagus, the premalignant precursor of oesophageal adenocarcinoma, is a metaplastic condition where the normal stratified squamous epithelium that lines the oesophagus is replaced by an intestinal-like columnar epithelium.
  The role of the breast microenvironment in suppressing early cancer invasion
  Assoc Prof B Parker, Dr D Zanker
Applications accepted all year round

Funding Type

PhD Type

Ductal carcinoma in situ (DCIS) is a pre-invasive stage of breast cancer, whereby the tumour cells remain restrained by myoepithelial cells that surround breast ducts.
  Therapy-induced senescence and stemness in ovarian cancer
  Prof R. Pearson, Dr K Chan
Applications accepted all year round

Funding Type

PhD Type

Cellular senescence is a stress response characterized by a robust cell cycle arrest and is a brake for malignant transformation.
  Transcriptional heterogeneity and resistance to therapy in prostate cancer
  Dr D. Goode
Applications accepted all year round

Funding Type

PhD Type

Androgen deprivation therapy (ADT) is a standard treatment for prostate cancer that works well in many cases but rapidly fails in others.
  Understanding the mechanisms of neuroendocrine tumour response to radionuclide therapy
  Prof R Hicks, Assoc Prof C Cullinane
Applications accepted all year round

Funding Type

PhD Type

Neuroendocrine tumours (NET) represent a heterogeneous group of tumours that arise in specialized cells found throughout the body.
  Unravelling the oncogenic activities of serum- and glucocorticoid-regulated kinase 1 (SGK1)
  Dr K Brown
Applications accepted all year round

Funding Type

PhD Type

The phosphoinositide 3-kinase (PI3K) pathway is a master regulator of numerous cellular phenotypes associated with cancer including cell survival, proliferation, growth, altered metabolism and malignant transformation.
  Using T cells to eradicate cancer
  Prof T. Tiganis
Applications accepted all year round

Funding Type

PhD Type

The Tiganis Laboratory is seeking a highly enthusiastic student to conduct research in immuno-oncology and the development of novel immunotherapeutic approaches for the treatment of cancer.
  Watching the Hippo pathway in real time in growing organs
  Dr K. Harvey
Applications accepted all year round

Funding Type

PhD Type

A new frontier in biomedical research will involve watching individual proteins work in real time, in living organs. Traditionally, researchers have drawn conclusions about gene function using indirect techniques that only allow us to infer what a gene normally does, without actually watching it work.
  International PhD Academy: Medical Research

Funding Type

PhD Type

Our vision is to impact locally, nationally and globally on biomedical and clinical research with a primary emphasis on health outcomes.
  Understanding resistance and tolerance to chytrid fungal disease in amphibians to improve conservation
  Dr L Grogan
Applications accepted all year round

Funding Type

PhD Type

This PhD project will involve working with captive animals (Australian barred frogs and tadpoles, including the endangered Fleay’s barred frog) to understand host responses to infection and mechanisms of resistance and tolerance to the devastating fungal disease, frog chytridiomycosis.
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