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We have 40 Pathology (human) PhD Projects, Programmes & Scholarships

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Pathology (human) PhD Projects, Programmes & Scholarships

We have 40 Pathology (human) PhD Projects, Programmes & Scholarships

An investigation on the association of high risk human papillomavirus (HPV) types with colonic adenomata and adenocarcinomas: a UK population based study

This PhD studentship invites application for a study “investigating the association between high risk human papillomavirus (HPV) types and colonic adenomata and adenocarcinomas in a UK population”.  Colorectal cancer (CRC) is an important public health problem worldwide occupying most frequent causes of cancer-related mortality. Read more

Our Mission: to Educate, Nurture and Discover for the benefit of Human Health

Founded in 1784 as the professional body for surgical training in Ireland, RCSI has evolved in the years since to become one of the world's leading health sciences universities. Read more

Vascularisation of tumour organoids for mechanistic and drug development

Gliomas such as are the most common form of brain tumour, a subset Glioblastoma (GBM) are devastating adult brain cancer with high rates of recurrence and treatment resistance. Read more

Experimental and computational Cancer PhD: Overcoming osteosarcoma chemoresistance by characterizing and targeting cellular quiescence

Cancer is the leading cause of death in children and the second in young adults in England and Wales. Sarcomas, tumours that originate from connective tissues (bone, muscle, fat), account for around 15% of childhood cancers. Read more

Investigating mechanisms of extra-cellular matrix remodelling and fibrosis in the gastrointestinal tract

Inflammatory bowel diseases, such as Crohn's disease, are increasing in prevalence globally. These are caused by chronic inflammation in the gut, there is no cure and medications are not effective for all. Read more

Combined treatments in knee osteoarthritis

Over recent years, the Centre for Human Movement and Rehabilitation (CHMR) has received extensive investment allowing us to develop world-class research facilities for PhD study. Read more

The Holistic Microbiome in Health and Disease: Linking the Oral, Gut and Respiratory Microbiomes

The human gut microbiome is recognised as a major determinant of health and disease. Studies to date, including those of the international Human Microbiome Project, have largely focused on individual body sites such as nose or mouth or faeces. Read more

Investigating Lysosomal Dysfunction in Ageing and Neurodegeneration

Lysosomes are key cellular organelles that degrade and recycle macromolecules, act as signalling hubs and are implicated in many diseases including Parkinson’s disease (PD) and Alzheimer’s dementia (AD) where old age is a major risk factor. Read more

Mechanisms of primary cilia formation

Affiliation. Masaryk University, Faculty of Medicine. Study program. Ph.D. program Biomedical Sciences. Specialization. Biochemistry and Molecular Biology. Read more

(MRC DTP CASE) Investigating the mechanisms contributing to impaired regulatory function of B cells in autoimmunity

The implementation of biological therapies has significantly advanced the management of autoimmune diseases (AIDs). However, the failure to achieve clinical remission in ‘non-responders’ remains a significant and unmet challenge. Read more

Systemic infections accelerate tau spreading by promoting glial activation

Alzheimer’s disease (AD) is a neurodegenerative disease, with a complex biology. In this PhD project, we aim to explore the cellular and molecular mechanisms underlying tau pathology. Read more

Investigation of short-term effects of colchicine on blood proteins using proteomics

The anti-inflammatory medication colchicine has been shown to significantly improve cardiovascular outcomes post heart attack and in chronic heart disease patient groups, suggesting it may be a suitable candidate for repurposing in cardiovascular diseases. Read more

Immune regulation of lung repair, and long-term consequences of infection

This project is one of 14 four year PhD Studentships funded by Medical Research Scotland (MRS) (https://www.medicalresearchscotland.org.uk) to be delivered jointly by the named University and External Partner Organisation (EPO). Read more

Study of early pathological changes in calcified cartilage in osteoarthritis and alkaptonuria

We are seeking a motivated individual to work on this exciting project investigating the role that the calcified cartilage has in rare and common joint osteoarthritis, using novel approaches such as gene silencing and establishment of a 3D chondrocyte cell culture model. Read more

Preclinical testing of collagen synthesis inhibitors for fibrotic disease

Fibrotic disease is characterised by an excessive accumulation of collagen within tissues, which then impedes tissue function. Organ fibrosis specifically kidney fibrosis, liver fibrosis, cardiac fibrosis and lung fibrosis have limited treatment options, pose a huge clinical burden and are life-limiting diseases. Read more

Alterations in reparative dentinogenesis with ageing, gender and genetic predisposition

Dental pulp exposure caused by tooth decay or injury can lead to life-threatening infections. Following injury, reparative dentinogenesis serves a vital purpose through the accelerated generation of tertiary dentine, comprising mineral and type I collagen. Read more

Unravelling the Intricacies of Stress Hormone Regulation

Project Overview. The proopiomelanocortin (POMC) pathway is a crucial signaling cascade involved in regulating various physiological processes, including our response to stress, metabolism, immune function, and pigmentation. Read more

Targeting the extracellular matrix remodelling for the treatment of obesity-associated cardio-renal dysfunction

Obesity is a risk factor for many chronic metabolic diseases including heart failure and chronic kidney disease. Our lab demonstrated a tight association between increased deposition of extracellular matrix components (e.g. Read more

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