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Pathology (knowledge) PhD Projects, Programs & Scholarships

We have 41 Pathology (knowledge) PhD Projects, Programs & Scholarships

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  Cutting off the fuel supply to starve cancer: Identifying metabolic vulnerabilities in cancer
  Dr K Brown, Dr A. Cox
Applications accepted all year round

Funding Type

PhD Type

A universal characteristic of all cancer cells is the reprogramming of cell metabolism to provide the energy and building blocks necessary to support proliferation and survival.
  Defining the role of p53 in cancer immunotherapy
  Prof Y. Haupt, Dr S. Haupt, Dr P. Neeson
Applications accepted all year round

Funding Type

PhD Type

Despite clear evidence of an association between the tumour suppressor p53 and immunity, a gap in knowledge exists regarding its role in modulating immune responses, or its value in predicting patient responses to immunotherapy.
  Elucidating the protein interaction network of serum- and glucocorticoid-regulated kinase 1 (SGK1)
  Dr K Brown
Applications accepted all year round

Funding Type

PhD Type

The phosphoinositide 3-kinase (PI3K) pathway is a master regulator of numerous cellular phenotypes associated with cancer including cell survival, proliferation, growth, altered metabolism and malignant transformation.
  How does amino acid metabolism affect tumour growth?
  Dr L. Cheng
Applications accepted all year round

Funding Type

PhD Type

The effect of diet on tumour growth is hotly debated but poorly characterized. Due to the heterogeneous nature of the tumours, dietary studies in patients with varied genetic background often led to inconclusive outcome.
  Metabolic reprogramming and chemotherapy resistance in triple-negative breast cancer
  Dr K Brown
Applications accepted all year round

Funding Type

PhD Type

Treatment options for the triple-negative breast cancer (TNBC) subtype of breast cancer are limited to conventional chemotherapy agents.
  PhD Scholarship in molecular biology of plant stress adaptation: The role of the membrane-associated NAC transcription factors
  Prof IA Dickie
Application Deadline: 21 June 2019

Funding Type

PhD Type

We seek a PhD candidate to join a 3-year research program based at the University of Canterbury (UC) to investigate the role of membrane associated NAC transcription factors in plant stress adaptation.
  EPSRC Centre for Doctoral Training in Sustainable Approaches to Biomedical Science: Responsible and Reproducible Research - SABS

Funding Type

PhD Type

Good degree in the Physical or Life Sciences? Interested in biological or medical research? We offer fully-funded PhD places across the Oxford Doctoral Training Centre programmes.
  Understanding the biology of male breast cancer to identify more precise ways to inform clinical decision making for personalised treatment strategies.
  Prof V Speirs, Dr R Abu Eid
Application Deadline: 28 June 2019

Funding Type

PhD Type

Breast cancer (BC) affects both genders but remains understudied in men. This is a concern; research from our and other laboratories show a rise in the number of men receiving a breast cancer diagnosis over the last 3 decades.
  Understanding the cytoskeletal and biophysical changes associated with fibroblast activation during scar formation
  Dr B Stramer, Dr T Shaw
Applications accepted all year round

Funding Type

PhD Type

A PhD studentship is available to work in the laboratory of Dr. Brian Stramer (https://www.kcl.ac.uk/lsm/research/divisions/randall/research/sections/motility/stramer/index) in the Randall Centre for Cell and Molecular Biophysics, King’s College London.
  The role of isothiocyanates-derived from natural sources in uveal melanoma chemoprevention (ref: SF18/APP/McDermott)
  Prof A McDermott, Prof M Panagiotidis, Dr G Koutsidis
Applications accepted all year round

Funding Type

PhD Type

Uveal melanoma is the most frequent primary intraocular tumor, in Caucasian adults, and one that is very difficult to treat once it becomes metastatic.
  Activation of targeted DNA Damage Response as a novel therapy for Ovarian Cancer
  Dr E. Sanij, Prof R. Pearson
Applications accepted all year round

Funding Type

PhD Type

High-grade serous ovarian cancer (HGSOC) is the most common and aggressive subtype of ovarian cancer and accounts for 70% of all ovarian cancer deaths.
  Characterize the role of Treacle (TCOF1) in AKT-regulated ribosome biogenesis
  Prof R. Pearson, Dr J Kang
Applications accepted all year round

Funding Type

PhD Type

Ribosomes are essential for cell growth and proliferation, and their biogenesis requires exquisite regulation.
  Control of tissue growth and cancer by the Hippo pathway
  Dr K. Harvey, Dr C Poon
Applications accepted all year round

Funding Type

PhD Type

A new frontier in biomedical research will involve watching individual proteins work in real time, in living organs. Traditionally, researchers have drawn conclusions about gene function using indirect techniques that only allow us to infer what a gene normally does, without actually watching it work.
  Development of targeted therapy for acute myeloid leukaemia with mutations in isocitrate dehysdrogenase
  Dr L. Kats
Applications accepted all year round

Funding Type

PhD Type

Acute Myeloid Leukaemia (AML) is an aggressive disease with poor prognosis and development of novel treatment options is urgently needed.
  Exploration of novel approaches to anti-cancer treatment: manipulation of mutant p53
  Prof Y. Haupt, Dr S. Haupt
Applications accepted all year round

Funding Type

PhD Type

P53 is the most mutated gene in human cancer, affecting about half the cases of human cancer. We have recently identified novel regulators of mutant p53 using sophisticated loss of function whole genome high through put screen (image 1).
  Finding a therapy for triple negative breast cancer patients
  Dr K. Britt
Applications accepted all year round

Funding Type

PhD Type

Triple negative breast cancers are a poor prognosis breast cancer with limited therapeutic options as they do not express estrogen receptors, progesterone receptors or Her2.
  Fishing for metabolic clues: Role of the Hippo/Yap pathway in reprogramming metabolism in liver cancer
  Dr A. Cox
Applications accepted all year round

Funding Type

PhD Type

The Hippo/Yap pathway is an evolutionarily conserved cascade that plays a fundamental role in governing organ size control, stem cell homeostasis and cancer.
  How is fate determined during T cell development, leukemogenesis and responses?
  Dr S. Russell
Applications accepted all year round

Funding Type

PhD Type

Understanding how cell fate programming works will lead to improved diagnostic and therapeutic opportunities for leukemia, and to improved immunotherapies for cancer and infectious disease.
  Impact of alternative mRNA splicing on the human proteome
  Dr V Wickramasinghe, Prof R. Pearson
Applications accepted all year round

Funding Type

PhD Type

Alternative splicing of RNA transcripts has emerged as a key mechanism for enabling biological complexity within the human genome.
  Impact of targeted therapy on the melanoma immune microenvironment
  Dr K. Sheppard, Prof G. McArthur
Applications accepted all year round

Funding Type

PhD Type

The treatment of melanoma is undergoing a fundamental change due to the success of both targeted therapies directed at the MAPK/ERK pathway and immunotherapies.
  Inhibition of PRMT5 as a cancer therapy
  Dr K. Sheppard, Prof G. McArthur
Applications accepted all year round

Funding Type

PhD Type

Targeted therapy has had profound impact on outcomes for cancer patients.
  Investigating the requirements of pro-inflammatory signaling in skin and head & neck Squamous Cell Carcinomas
  Dr C Darido
Applications accepted all year round

Funding Type

PhD Type

Squamous cell carcinomas (SCC) are amongst the most common cancer types afflicting man. SCCs most frequently arise from stratified squamous epithelia such as the epidermis or the mucosae of the head and neck.
  Mechanisms of regulating gene expression via selective mRNA transport
  Dr V Wickramasinghe, Prof R. Pearson
Applications accepted all year round

Funding Type

PhD Type

A critical step in the gene expression pathway that is altered in cancer is nuclear export of mRNA. We have demonstrated that mRNA export is not constitutive, but highly selective and can regulate distinct biological processes through poorly understood mechanisms.
  Metabolic Reprogramming in Liver Cancer: delineating the role of reactive oxygen species (ROS) in tumour development
  Prof T. Tiganis
Applications accepted all year round

Funding Type

PhD Type

The Tiganis Laboratory is seeking a highly enthusiastic student to conduct research in cancer metabolism and obesity-associated liver cancer.
  Metabolic rewiring in liver cancer: Role of oxidative stress and the Nrf2 pathway
  Dr A. Cox
Applications accepted all year round

Funding Type

PhD Type

Many of the major risks factors for developing liver cancer such as alcohol, obesity, smoking and toxin exposure share in common a role for oxidative stress.
  Personalised risk evaluation in DCIS: are there molecular biomarkers that can predict which DCIS are at higher risk for recurrence?
  Dr K. Gorringe, Prof I. Campbell
Applications accepted all year round

Funding Type

PhD Type

Breast screening using mammography has seen an increased detection of not only invasive breast cancer, but also pre-invasive lesions such as ductal carcinoma in situ (DCIS).
  Predicting the development of oral cancer
  Dr C Darido
Applications accepted all year round

Funding Type

PhD Type

Human head and neck cancer is a devastating disease with poor survival rates.
  Regulation and function of cytotoxic lymphocytes
  Dr I. Voskoboinik, Prof J.A. Trapani
Applications accepted all year round

Funding Type

PhD Type

Cytotoxic lymphocytes recognize and kill cancerous and virus-infected cells through cytotoxic granule exocytosis pathway. Cytotoxic granules store a pore-forming protein, perforin, and serine proteases, granzymes.
  Role of the tumour microenvironment in gastric cancer
  Dr A. Boussioutas, Dr R. Busuttil
Applications accepted all year round

Funding Type

PhD Type

Gastric cancer (GC) is the fourth most common cancer globally and 7th in incidence in Australia. It has a poor survival rate which can be attributed to the advanced stage at diagnosis in most patients.
  Therapy-induced senescence and stemness in ovarian cancer
  Prof R. Pearson, Dr K Chan
Applications accepted all year round

Funding Type

PhD Type

Cellular senescence is a stress response characterized by a robust cell cycle arrest and is a brake for malignant transformation.
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