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University of Cambridge Pathology PhD Projects, Programs & Scholarships

We have 10 University of Cambridge Pathology PhD Projects, Programs & Scholarships

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  BBSRC DTP targeted studentship - Investigating the role of herpesvirus glycoprotein E in modulation of antiviral host responses and virus spread.
  Dr C Crump
Application Deadline: 3 January 2019
Herpesviruses are highly successful pathogens that cause disease in animals and humans. In particular, the alphaherpesvirus subfamily includes significant veterinary pathogens many of which are designated notifiable diseases by the Department for Environment, Food and Rural Affairs.
  BBSRC DTP targeted studentship - The role of RNA elements that control protein synthesis during host pathogen interaction
  Dr B Chung, Dr G Fraser, Dr A Firth
Application Deadline: 3 January 2019
Understanding host responses to pathogen infection is critical for guiding the development of intervention strategies. Changes in gene expression are commonly observed upon infection, as exemplified by numerous transcriptomic studies.
  Characterisation of the mechanism of norovirus VPg-dependent RNA synthesis.
  Prof I Goodfellow
Application Deadline: 3 January 2019
Noroviruses have an impact of >$60 billion pa, yet we have no vaccines or therapeutics. This project will use a combination of molecular and biochemical approaches to dissect norovirus VPg-primed RNA synthesis.
  Characterization of clonal evolution of T-cell lymphoma
  Prof M Q Du
Application Deadline: 3 January 2019
It has long been assumed that malignant T-cell lymphoma is a monoclonal disease. i.e. the tumour grows and expands from a single cell.
  Characterization of the roles of PP1 phosphatases in cytokinesis
  Dr P D'Avino
Application Deadline: 3 January 2019
Cell division faithfully partitions the genomic information between the two daughter cells and errors in this process have been implicated in many human diseases.
  Early PI3-mediated translation response during intracellular bacterial and viral infection
  Dr B Chung
Application Deadline: 3 January 2019
Biotic stresses often occur on short timescales, making rapid response crucial for survival of both host and pathogen. Cells respond to stress by regulating gene expression at multiple steps but especially transcription, translation and protein turnover.
  Investigate the mechanism by which vaccinia virus exploits microtubules to transport new virions to the cell periphery
  Prof G L Smith
Application Deadline: 21 December 2018
Vaccinia virus is the live vaccine that was used to eradicate smallpox. After smallpox eradication, VACV has been exploited to build vaccines against other diseases and continues to be studied to better understand virus interactions with the host cell and the immune system.
  Understanding the role of the Guanosine Trimethylase TGS1 in Acute myeloid leukaemia
  Dr I Barbieri
Application Deadline: 3 January 2019
RNA methylation is a reversible post-translational modification to RNA that epigenetically numerous biological processes. The biological and molecular functions of RNA methylation are generally very poorly understood, both in normal and pathological biological processes.
  Exploring aberrant inflammasome activation in chronic granulomatous disease
  Dr S Webster, Prof C E Bryant
Applications accepted all year round
This project will test the hypothesis. Aberrant inflammasome activation can be caused by mitochondrial ROS mediated NLRP3 inflammasome activation.
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