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Pharmaceutical Chemistry PhD Projects, Programmes & Scholarships

We have 123 Pharmaceutical Chemistry PhD Projects, Programmes & Scholarships

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We have 123 Pharmaceutical Chemistry PhD Projects, Programmes & Scholarships

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Design of a buccal patch for delivery of a GLP-1 peptide

Delivery of peptides via non-injected routes remains an unmet medical need. Delivery across the cheek is attractive and has some advantages over oral including avoidance of a food effect and a lower first pass effect. We have discovered a permeation enhancer that can be incorporated into a buccal patch system (. Read more

Design of novel inhibitors of AIM-2 for the treatment of inflammation.

Inflammation is a contributing factor in a range of therapeutic areas including stroke, Alzheimer’s disease and cancer. A cause of Inflammation is through the activation of multi-protein complexes called inflammasomes, which facilitates the release of cytokines, including IL-1b. Read more

Probing Viral Receptor-Glycan Interactions using Polyvalent Multifunctional Glycan-Nanoparticle

  Research Group: School of Chemistry
Multivalent viral receptor-glycan interactions are central to viral infection and immune response regulation. However, the underpinning structural mechanisms are often poorly understood, due to a lack of effective probes for such complex, multimeric and flexible proteins. Read more

Cell-type dependent pharmacological regulation of cellular mitophagy for therapeutic application in Parkinson’s disease

The cellular quality-control process of mitophagy, entailing selective degradation of defective mitochondria (following damage to their DNA) by the process of autophagy, has attracted considerable research interest. Read more

Catalytic Asymmetric ‘Clip-Cycle’ Reactions: Synthesis of Heterocycles Important in Drug Discovery

Cyclic ethers and amines are ubiquitous in biologically active natural and non-natural products. However, despite this prevalence and importance, there is no strategy for their asymmetric synthesis which is independent of heteroatom and/or ring size. Read more

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