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Pharmaceutical Chemistry PhD Projects, Programmes & Scholarships
We have 124 Pharmaceutical Chemistry PhD Projects, Programmes & Scholarships
We have 124 Pharmaceutical Chemistry PhD Projects, Programmes & Scholarships
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Molecular Design for Drug Discovery
Background. Drug resistance is a growing concern for the future of effective medicine. For this reason, new paradigms in drug design are actively being sought. Read more
Enhancing Protein and Ligand Sampling in Molecular Simulations by Fully Adaptive Simulated Tempering (FAST)
Supervisory Team. Prof J.W. Essex, Dr Michael Bodnarchuk (AZ), Dr Ian Wall (GSK). Project description. Binding free energy calculations are a widely used technique in the pharmaceutical industry to identify molecules which may be usefully developed into drug candidates. Read more
Prediction of Structure and Stability of Amorphous Pharmaceuticals
70% of drug candidates in early development show poor aqueous solubility. Read more
Prediction of Manufacturability and Transformations During Amorphous Pharmaceuticals Processing
KEYWORDS. Pharmaceuticals, manufacture, polymers, materials science, modelling, 3D printing, extrusion, formulation. CMAC is a world leading medicines manufacturing research center that hosts a portfolio of collaborative research programs aimed to transform the development and manufacture of medicines (www.cmac.ac.uk). Read more
Understanding and scale up of secondary nucleation in pharmaceutical crystallisation
Nucleation of crystals from solution is a crucial part of many manufacturing processes, in global sectors including pharmaceuticals, medicine, foods, chemicals and advanced materials. Read more
Optimising the washing and drying of filter cakes: modelling and applications
The aims of project are to understand fluid transport through filter cakes, and how it is influenced by particle sizes and cake structural properties; Investigate the consequences of this fundamental understanding for washing and drying, which are key processes in the manufacture of pharmaceuticals; and design improved strategies for isolation of particulates that facilitate further processing. Read more
Designing surfaces to control nucleation in pharmaceutical crystallisation
Crystallisation is widely used for purification of chemicals and pharmaceuticals and for making advanced materials for catalysis, separations and sensing applications. Read more
Solvent reuse to support sustainable pharmaceutical manufacturing
This project aims to develop and demonstrate solvent recycling methodologies which can be applied within individual process stage during advanced continuous pharmaceutical synthesis and active pharmaceutical ingredient isolation. Read more
Investigation of pharmaceutical crystallisation using small angle x-ray scattering
Small-angle X-ray scattering (SAXS) offers various ways to characterize nanoscale structures of pharmaceutical crystal and large molecules. Read more
Predicting drug solubility in different solvents using molecular simulation and machine learning
Predicting the solubility of complex drug-like molecules is crucial at several stages of the drug discovery and manufacture. In particular, solvent selection has been highlighted as a crucial step in process design and optimisation [1]. Read more
Neuropeptide Research – PhD Position at a World Class Institution
Neuropeptides are key mediators in many biological functions and understanding their interaction with target proteins is fundamental to unravel the underlying mechanism of diseases. Read more
Mechanistic models for protein binding and transport in organ impairment
When evaluating impact of disease on drug response, measurement of total drug concentration is typically used as surrogate for free drug concentration and pharmacological effect. Read more
Antimicrobial drug development: Synthesis, characterisation, and evaluation of novel antimicrobial agents to combat antimicrobial resistance.
Vaccines and antibiotics have been at the forefront in the prevention and treatment of infectious diseases. However, the indiscriminate use of antibiotics has led to the development of antimicrobial resistance (AMR). Read more
Biochemical Optimisation of a Male Contraceptive
The development of a reversible and non-hormonal male contraceptive will supplement existing birth control options to achieve a significant impact upon the numbers of unwanted pregnancies, a major global problem. Read more
Automated Dynamic Flow System for Efficient Mapping of Reaction Design Spaces
Research Group:
School of Chemical and Process Engineering
This project proposes to couple the automated flow reactor platforms to dynamic trajectory techniques for pharmaceutical chemical case studies. Read more