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We have 12 Pharmaceutical Chemistry (enzyme) PhD Projects, Programmes & Scholarships

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Pharmaceutical Chemistry (enzyme) PhD Projects, Programmes & Scholarships

We have 12 Pharmaceutical Chemistry (enzyme) PhD Projects, Programmes & Scholarships

Development of molecularly imprinted polymers (MIPs) assisted analytical methods for detection and monitoring of protein/enzyme biomarkers

Biomarkers have been used prolifically in the field of medicine to provide a rapid and easy method of monitoring many normal biochemical pathways and many pathological conditions without the need for any invasive procedures [1,2]. . Read more

Enzyme-responsive peptide hydrogels as in situ forming long-acting drug delivery implants

One of the key issues in the treatment and prevention of disease is that patients struggle to adhere to the complex dosage regimens of therapies, which often require multiple dosing at very specific times each day. Read more

High-throughput characterization and engineering of nucleotide synthases for production of nucleoside analogues

Nucleotides are the building blocks of life, modulating diverse processes from protein production to cell signalling. It is therefore unsurprising that synthetic nucleoside analogues have been developed as therapeutics for the treatment of a wide range of diseases including cancers and viral infections. Read more

Discovery and profiling of small-molecule inhibitors of cellular nuclease enzymes

Nuclease enzymes are non-traditional drug targets that attract an increasing amount of interest as potential targets relevant for a variety of therapeutic areas including infection, cancer and bone disease. Read more

Cardiotoxicity of Anticancer Drugs

Faculty of Pharmacy, Charles University, Department of Biochemical Sciences. The project fits into the field of cardio-oncology, which deals with the detection, prevention and treatment of cardiovascular diseases that occur as a side effect of chemotherapy and radiotherapy. Read more

Design, synthesis and evaluation of novel polysialyltransferase inhibitors as anti- metastatic agents

  Research Group: Institute of Cancer Therapeutics
Polysialic acid plays an essential role in neuronal development, but by adulthood is absent from the human body. Its biosynthesis is regulated by two polysialyltransferases (polySTs). Read more

Design and study of modified peptide foldamers

These projects are open to students worldwide, but have no funding attached. Therefore, the successful applicant will be expected to fund tuition fees at the relevant level (home or international) and any applicable additional research costs. Read more

Towards the development of a novel class of broad-spectrum anti-infective drugs

Through exceptionally strong research collaborations at the interface of chemistry, biology, and medicine, we have applied innovative thinking to the field of (Minor Groove Binders) MGBs to develop a novel platform for drug discovery with the potential to treat an impressive range of diseases, including bacterial, fungal, parasitic, and viral infections. Read more
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