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Pharmaceutical / Medicinal Chemistry (structural biology) PhD Projects, Programs & Scholarships

We have 14 Pharmaceutical / Medicinal Chemistry (structural biology) PhD Projects, Programs & Scholarships

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  Establishing NMR chemical shifts as reliable reporters of atomic charge distributions in enzymes
  Prof J Waltho, Prof P Popelier
Applications accepted all year round

Funding Type

PhD Type

Enzymes are not only central to life but also to the growing need to harness elements of the natural world to the benefit of mankind.
  PhD in Chemical Biology -- Neuropeptide Research -- University of Vienna
  Prof M Muttenthaler
Applications accepted all year round

Funding Type

PhD Type

Neuropeptides are key mediators in many biological functions and understanding their interaction with target proteins is fundamental to unravel the underlying mechanism of diseases.
  Molecular mechanisms of herpesviral infection
  Dr A Golovanov
Applications accepted all year round

Funding Type

PhD Type

Herpes viruses are known to cause a wide range of human diseases, ranging from simple cold sores to cancer, Kaposi Sarcoma. Kaposi Sarcoma, for example, is a type of cancer which affects immunocompromised patients and is endemic in Africa, where it is linked with the spread of HIV infection and AIDS.
  The chemistry and biophysics of phosphoryl transfer enzymes
  Prof J Waltho, Dr A Almond
Applications accepted all year round

Funding Type

PhD Type

One of the most remarkable features of the chemistry of living organisms is the evolutionary utilisation of phosphate esters to provide biopolymers that encode genetic information, deliver temporal protein regulation, generate and distribute free energy throughout the cell, and to provide a ubiquitous handle for metabolic intermediates.
  The chemical glycobiology of carbohydrate metabolism
  Prof R Field, Prof S Flitsch
Applications accepted all year round

Funding Type

PhD Type

Carbohydrates are widespread in nature and fulfil many important biological functions. However, the biology of carbohydrates is much less well explored than that of nucleic acids and proteins.
  Computer Simulations of G protein-coupled Receptors
  Dr I Tikhonova
Applications accepted all year round

Funding Type

PhD Type

Many physiological processes are controlled through the activation of G protein-coupled receptors (GPCRs) by regulatory peptides, making peptide GPCRs particularly useful targets for major human diseases such as diabetes and CNS diseases.
  Biocatalytic Approaches for the Synthesis of Therapeutic Oligonucleotides
  Dr S Lovelock, Dr A Green
Applications accepted all year round

Funding Type

PhD Type

Therapeutic oligonucleotides are short DNA analogues which selectively bind to target mRNA through Watson-Crick base pairing to regulate the production of disease related proteins.
  Carbohydrate analysis for biomedical applications.
  Dr S Allman
Applications accepted all year round

Funding Type

PhD Type

Changes in the patterns of carbohydrates produced by the cell can provide insights into disease states, revealing perturbations and differences in cellular metabolic processes.
  Cationic antimicrobial peptides as anticancer agents
  Dr R Green, Prof R A Frazier
Applications accepted all year round

Funding Type

PhD Type

Cationic peptides are widespread in nature where they play a key role in host defense within plants and animals. The mechanism by which these peptides interact with cell membranes potentially leads to these being less prone to antimicrobial resistance than conventional antibiotics.
  Characterising surface properties of protein biopharmaceutical molecules
  Dr A Golovanov, Dr J Warwicker
Applications accepted all year round

Funding Type

PhD Type

Protein biologicals have great potential for the effective treatment of a wide range of diseases. However, aggregation and instability are inherent issues with all protein pharmaceuticals, which is a problem that can limit their utility and developability.
  Integrating mass spectrometry metabolomics, imaging and bioinformatics to develop physiology-based kinetic models for chemical safety science
  Prof M Viant, Dr B Campos, Dr C Rivetti, Dr I Sorrell
Application Deadline: 1 April 2020

Funding Type

PhD Type

**If you are interested in this studentship, it is vital to contact Professor Mark Viant prior to applying with a copy of your CV.
  PhD in Chemistry – Molecular design, chemical synthesis and structural characterisation of novel peptides and peptidomimetics
  Dr A Jamieson
Application Deadline: 31 August 2020

Funding Type

PhD Type

Peptides derived from natural sources are useful lead compounds to develop therapeutics. The structural diversity of naturally occurring peptides covers a large section of chemical space that sits between more traditional small molecules (.
  Design and synthesis of novel, targeted, anti-cancer agents
  Prof H Osborn, Dr F Greco
Applications accepted all year round

Funding Type

PhD Type

One of the major problems of cancer chemotherapy is that the drugs used have poor selectivities for cancer cells and cause damage to normal cells and organs.
  Nanotechnologies for cancer: developing new polymer-drug conjugates for the treatment of a range of cancers
  Dr F Greco, Prof H Osborn
Applications accepted all year round

Funding Type

PhD Type

Polymer anticancer-drug conjugates are drug delivery systems in which a low molecular weight anticancer agent is covalently conjugated to a water-soluble polymeric carrier.
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