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Pharmacology / Toxicology (amyloid) PhD Projects, Programs & Scholarships

We have 5 Pharmacology / Toxicology (amyloid) PhD Projects, Programs & Scholarships

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  Investigating the link between amyloid-β oligomers, neuroinflammation and cognitive deficits in preclinical models for Alzheimer’s Disease
  Dr M Harte, Prof J Neill
Applications accepted all year round

Funding Type

PhD Type

Currently four out of the five pharmacological treatments used for Alzheimer’s disease (AD) are acetylcholinesterase inhibitors aimed at boosting the amount of acetylcholine in the brain, with the fifth being an N-methyl-D-aspartate (NMDA) receptor antagonist.
  MRC DiMeN Doctoral Training Partnership: Investigating the in vivo targets and mechanism of action of a toxic acetylcholinesterase-derived peptide upregulated in Alzheimer’s disease
  Dr M Collins, Prof S Greenfield
Application Deadline: 6 January 2020

Funding Type

PhD Type

Alzheimer’s disease (AD) is a progressive neurodegenerative disease that is characterised by the deposition and accumulation of amyloid beta plaques and phosphorylated tau filaments in the brain, the latter correlating with the onset of symptoms.
  Investigations into the neuroprotective actions of leptin and leptin-based mimetics in models of tauopathy.
  Dr J Harvey
Applications accepted all year round

Funding Type

PhD Type

In neurodegenerative disorders like Alzheimer’s disease (AD), synaptic communication within brain networks are impaired leading to significant memory deficits and dementia.
  Analysing the factors that regulate expression of blood-brain barrier drug transporter proteins
  Dr J L Penny, Dr C Demonacos
Applications accepted all year round

Funding Type

PhD Type

In order to treat diseases associated with the central nervous system (CNS), e.g. cancer, Parkinson’s disease, depression, it is essential for therapeutic drugs to be able to penetrate into the brain.
  Fly, mouse and computational modelling of the effect of Alzheimer’s disease on clock neuron excitabilit
  Dr J Hodge, Prof K Tsaneva-Atanasova
Application Deadline: 25 November 2019

Funding Type

PhD Type

Alzheimer’s disease (AD) involves amyloid-B and tau accumulation resulting in memory, sleep and circadian rhythm loss. How this occurs is unknown hampering the development of effective AD drugs.
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