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We have 17 Pharmacology (data analysis) PhD Projects, Programmes & Scholarships

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Pharmacology (data analysis) PhD Projects, Programmes & Scholarships

We have 17 Pharmacology (data analysis) PhD Projects, Programmes & Scholarships

Integrated omics approach to psychiatric disorders

  Research Group: Chemistry and Biosciences
In psychiatry, the selection of antipsychotics and antidepressants is led by a trial-and-error approach. The prescribing of these medications is complicated by sub-optimal efficacy and high rates of adverse drug reactions (ADRs). Read more

Inflammatory Arthritis in Childhood: Impact, Outcomes and Safety of Treatment

Juvenile Idiopathic Arthritis is the most common inflammatory arthritis of childhood. Although less common than arthritis in adults, a diagnosis of arthritis in a child can have lasting impacts on that child and their families through their entire lifespan. Read more

Exploring Innovative Approaches in Chronic Pain: Focus on Neuropathic pain and Spinal Cord Stimulation

Pain can be a debilitating long-term and persistent symptom in many medical conditions, adversely affecting quality of life. Neuropathic pain originates from nervous system damage, resulting in deficits in neural transmission leading to sensory, autonomic, and motor impairment. Read more

Application and development of bioinformatics and network theory methods in cardiovascular disease research and pharmacovigilance

To be able to discover novel drug targets we aim to develop software based on network theoretic approaches that are capable to identify mediators and pathways involved in the pathomechanism of various cardiovascular diseases by the analysis of datasets assessed with high throughput molecular biological techniques (e.g. Read more

Discovering off-target side-effects and drug repurposing candidates using expression perturbation data

The MRC Integrative Epidemiology Unit at the University of Bristol is the leading group for the development and application of causal analysis and evidence triangulation in health research to improve lives. Read more

Analysis of the role of liver sinusoidal endothelial cells in methotrexate-induced liver toxicity

Liver sinusoidal endothelial cells (LSECs) comprise approximately 50% of the non-parenchymal hepatic cells. They play a vital role in hepatic microcirculation and provide a physiological barrier to the movement of xenobiotics from the bloodstream to hepatic tissue. Read more

Transcriptome biomarkers and mechanisms of chemoresistance

Project Summary. This project aims to identify biomarkers linked to the most potent multimodal anticancer therapy with the least toxicity to counteract hemoresistance in head and neck squamous cell carcinoma (HNSCC). Read more

Structure-based design of allosteric modulators for G protein-coupled receptors using molecular modelling and pharmacology experiments

Almost all physiological processes are regulated through the activation of G protein-coupled receptors (GPCRs). It has become widely accepted that most GPCRs possess binding sites spatially distinct from their natural ligand binding site (orthosteric site), termed as allosteric sites. Read more

Investigating the links between β-amyloid, osteoporosis and frailty in Alzheimer’s disease

Background. Individuals with Alzheimer’s disease are more likely to suffer from osteoporosis (the loss of bone mass and strength) than age-matched individuals1, significantly contributing to the frailty associated with dementia. Read more

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