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We have 83 Pharmacology (drug) PhD Projects, Programmes & Scholarships

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Pharmacology (drug) PhD Projects, Programmes & Scholarships

We have 83 Pharmacology (drug) PhD Projects, Programmes & Scholarships

Discovering off-target side-effects and drug repurposing candidates using expression perturbation data

The MRC Integrative Epidemiology Unit at the University of Bristol is the leading group for the development and application of causal analysis and evidence triangulation in health research to improve lives. Read more

Endosomal Sorting Complex Required for Transport (ESCRT): Investigation of the role in acquired drug resistance in colon cancer

  Research Group: Institute of Cancer Therapeutics
Despite treatment advances, one of the most common cancers, colorectal cancer (CRC), still has a 45% mortality rate, and one of the major problems is the build-up of resistance to cancer drugs during treatment (‘acquired resistance’) such that over time the drugs stop working. Read more

Novel design and formulation strategies to enhance drug delivery

The main research activities of my research group concern the improvement of traditional drug formulation and development of novel drug and formulation strategies to enhance bioavailability and patient acceptability. Read more

Drug metabolism - prediction, detection, and isolation

Electrosynthesis (ES) is a green methodology for preparing and interpreting drug metabolites linked to toxicology. ES describes the synthesis of chemical compounds in an electrochemical cell. Read more

Investigating how dormant senescent cells can drive drug-resistance following chemotherapy

Most anti-cancer chemotherapeutics work by inducing DNA damage and arresting the cell cycle in either G1 or G2 phase. A frequent outcome of this arrest is that cells exit the cell cycle into a state known as senescence. Read more
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Study on the role of pharmacokinetic mechanisms in the anticancer drug resistance and possibility of their modulation

Faculty of Pharmacy, Charles University, Department of Pharmacology and Toxicology . Drug resistance represents a critical obstacle to successful anticancer pharmacotherapy. Read more

Vascularisation of tumour organoids for mechanistic and drug development

Gliomas such as are the most common form of brain tumour, a subset Glioblastoma (GBM) are devastating adult brain cancer with high rates of recurrence and treatment resistance. Read more

Pharmacokinetics Guided Natural Products Exploration for Drug Discovery, Development, Delivery and Therapy

  Research Group: Institute of Cancer Therapeutics
Natural products have emerged as a key standard in novel and safe delivery of anticancer bioactive compounds. Apart from their ease of administration and delivery, natural/phytochemicals still face several hurdles, due to their physiochemical and pharmacokinetic properties. Read more

Development of antibody-drug conjugates (ADCs) for oncology indications

  Research Group: Institute of Cancer Therapeutics
A major challenge in cancer therapy is to develop therapeutic agents that selectively target tumour cells but are not harmful to normal tissue. Read more

Design, synthesis and evaluation of protease-activated anti-cancer prodrugs

  Research Group: Institute of Cancer Therapeutics
Matrix metalloproteinases (MMPs) are a family of endoproteases that are overexpressed in tumours and play crucial roles in many tumourigenic processes, not least tumour invasion and angiogenesis. Read more

Transcriptome biomarkers and mechanisms of chemoresistance

Project Summary. This project aims to identify biomarkers linked to the most potent multimodal anticancer therapy with the least toxicity to counteract hemoresistance in head and neck squamous cell carcinoma (HNSCC). Read more

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