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Pharmacology / Toxicology (information studies) PhD Projects, Programs & Scholarships

We have 35 Pharmacology / Toxicology (information studies) PhD Projects, Programs & Scholarships

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Showing 1 to 15 of 35
  Inhibition of PRMT5 as a cancer therapy
  Dr K. Sheppard
Applications accepted all year round

Funding Type

PhD Type

Targeted therapy has had profound impact on outcomes for cancer patients.
  RNA Methylation in normal and malignant blood development
  Dr L. Kats
Applications accepted all year round

Funding Type

PhD Type

As is the case with DNA and histones, RNA can also be modified and indeed more than 100 chemical groups that decorate all four canonical RNA nucleotides have been described.
  Modification of marketed dosage forms for administration to children
  Dr F O'Brien, Dr M Peak
Applications accepted all year round

Funding Type

PhD Type

Can guidance be provided to allow pharmaceutical companies to develop approvable strategies for alternative methods of administration of medicines to children when the marketed dosage form does not provide the required dose and/or is not acceptable to the child or carers?.
  Metabolic Reprogramming in Liver Cancer: delineating the role of reactive oxygen species (ROS) in tumour development
  Prof T. Tiganis
Applications accepted all year round

Funding Type

PhD Type

The Tiganis Laboratory is seeking a highly enthusiastic student to conduct research in cancer metabolism and obesity-associated liver cancer.
  Cutting off the fuel supply to calcium pumps in pancreatic cancer: a novel therapeutic strategy
  Dr J Bruce, Prof K Williams, Dr A P Gilmore
Applications accepted all year round

Funding Type

PhD Type

Background and Rationale. Pancreatic ductal adenocarcinoma (PDAC) has the poorest survival and limited treatment options. Therefore, the search for novel therapeutic targets and drugs designed to selectively kill PDAC cells must remain a central research strategy.
  Cardiac energetics and integrative physiology: Studying key components of the creatine kinase system to understand how they contribute to the pathophysiology of ischaemic heart disease and chronic heart failure.
  Prof C Lygate, Dr S Zervou
Application Deadline: 24 July 2020

Funding Type

PhD Type

Studying key components of the creatine kinase system to understand how they contribute to the pathophysiology of ischaemic heart disease and chronic heart failure.
  Complement escape by malaria parasites
  Prof S Meri, Prof V Fremeaux-Bacchi
Application Deadline: 10 May 2020

Funding Type

PhD Type

The fact that various stages of the malaria parasites can survive in human blood suggest that they are capable of escaping destruction by the host complement system.
  Structure based design of angiotensin-converting enzyme (from Anopheles gambiae) inhibitors as mosquitocides
  Prof K R Acharya
Applications accepted all year round

Funding Type

PhD Type

The mosquitoes of the Anopheles and Aedes genus are some of the most deadly insects to humans because of their effectiveness as vectors of malaria and a range of arboviruses, including yellow fever, dengue, chikungunya, West Nile and zika.
  Stimuli-responsive biopolymers for life science, materials and therapeutic applications
  Dr M Soloviev
Applications accepted all year round

Funding Type

PhD Type

This is a self-funded project, match-finding option may be available for qualifying candidates. Please include a detailed CV with any enquiries.
  Improving our understanding of the Meningococcal Disease with the Genomic sequencing for variants in complement genes
  Prof V Fremeaux-Bacchi, Prof S Meri
Application Deadline: 10 May 2020

Funding Type

PhD Type

Antibodies and complement undoubtedly play major roles in determining clinical outcomes following acquisition of a N. meningitidis strain, but in some instances it causes catastrophic invasive infection.
  MASTERS BY RESEARCH PROJECT: Can we improve patient outcomes by providing a more personalized approach to antiplatelet therapies?
  Dr S Mundell
Applications accepted all year round

Funding Type

PhD Type

Start 23 September 2019. This MSc by Research is a laboratory-based project which offers the exciting opportunity to spend 1 year in one of our State-of-the-Art laboratories (plus 1 year thesis writing) at the University of Bristol and experience life as a researcher.
  Characterization of C5aR2 expression and function in Toxoplasma gondii infection
  Prof J Koehl, Prof D Wilflingseder
Application Deadline: 10 May 2020

Funding Type

PhD Type

Toxoplasma gondii (T. gondii) is a widespread obligate intracellular protozoan parasite. It is of major medical importance during pregnancy and in immunocompromised individuals.
  Hydrogen sulphide as a treatment for respiratory disease.
  Dr R Roberts, Dr SPH Alexander
Applications accepted all year round

Funding Type

PhD Type

We have demonstrated that hydrogen sulphide (H2S) is synthesised within the airways in the lungs. H2S synthesis in the airways occurs through activation of the enzymes cystathionine  lyase, cystathionine β synthase, and mercaptopyruvate sulphurtransferase (MPST).
  Understanding structure and drug binding in the multidrug pump ABCG2
  Dr I Kerr, Dr R Layfield
Applications accepted all year round

Funding Type

PhD Type

ABCG2 is one of three human ATP binding cassette transporters that are functionally capable of exporting a diverse range of substrates from cells.
  Epigenetic mechanisms of behavioural, placental and cognitive impairment in a neurodevelopmental model for schizophrenia
  Dr R Hager, Prof J Neill, Dr J Glazier
Applications accepted all year round

Funding Type

PhD Type

A fundamental question in disease research is how stressors experienced during critical developmental periods influence the genesis or ‘programming’ of adult disease (Estes & McAllister 2016).
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