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Pharmacology / Toxicology (vascular) PhD Projects, Programs & Scholarships

We have 22 Pharmacology / Toxicology (vascular) PhD Projects, Programs & Scholarships

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We have 22 Pharmacology / Toxicology (vascular) PhD Projects, Programs & Scholarships

Effect of vitamin D in vascular and endocrine cells

Vitamin D3 deficiency is a common public health problem worldwide that is increasingly believed to contribute not only to decreased bone mineralisation but potentially to other serious medical conditions. Read more

Exploring the similarities between neointimal formation after vascular injury and tumour growth

Rationale. Vascular smooth muscle cell (VSMC) proliferation leads to intimal thickening, which causes reoccurrence of symptoms (restenosis) in 30-50% of coronary artery disease patients receiving saphenous vein grafts and individual receiving stent implantation. Read more

Characterisation of novel inhibitors of vascular injury due to inflammation

Myeloperoxidase (MPO) is a haemoprotein that is highly expressed in neutrophils and is secreted during injury and inflammation to assist in host defence reactions by producing antimicrobial reactive oxygen species. Read more

Investigating microvascular dysfunction in sickle cell disease (SCD)

Cerebrovascular disease is a leading cause of mortality worldwide, with numbers on the rise. It is a serious complication of a number of disease states, including sickle cell disease (SCD), an inherited autosomal recessive disorder, resulting from a single amino acid substitution in the haemoglobin β chain. Read more

Impact of normal and premature ageing on human macro- and microvasculature

  Research Group: Centre for Skin Sciences
The global population is growing, with the number of births consistently higher than the number of deaths. This is because people are living for longer, due at least in part to improved lifestyle and healthcare provision. Read more

Characterisation of the role of Panx1/Panx2 in primary endothelial cells

Pannexins are a family of proteins that are evolutionary related to the gap-junction forming proteins, innexins (1). Three members have been identified, Panx1, Panx2 and Panx3, and they show distinct tissue distribution. Read more

The effect of age on arterial remodelling: relevance to atherosclerotic plaque progression and aneurysm formation

Brief Rationale. Atherosclerosis is an inflammatory vascular disease involving plaques composed of lipid-dense cores filled with activated, apoptotic and necrotic inflammatory and vascular cells coated with a fibrous cap. Read more

Elphinstone Scholarship - Novel drug targets for pulmonary arterial hypertension: dissecting the phosphodiesterase 1 signalsome

Pulmonary arterial hypertension (PH), which is high blood pressure in the lung, is characterized by increased pulmonary artery smooth muscle cells (PASMC) in the walls of the blood vessels, raised pulmonary vascular resistance, right ventricular failure and premature death. Read more

Smoking and psoriasis: does smoking augment the angiogenic drive to the development of psoriasis and does smoking cessation have utility for psoriasis management?

Vascular endothelial growth factor A (VEGF-A)-mediated angiogenesis plays a key role in the pathogenesis of psoriasis; a common, inflammatory disease associated with significant extracutaneous morbidity and psychological distress. Thus, patients with psoriasis live with a complex multi-system disease which be a barrier to healthy lifestyle choices. . Read more

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