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Pharmacology / Toxicology (structural biology) PhD Projects, Programs & Scholarships

We have 17 Pharmacology / Toxicology (structural biology) PhD Projects, Programs & Scholarships

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  PhD in Chemical Biology -- Neuropeptide Research -- University of Vienna
  Prof M Muttenthaler
Applications accepted all year round

Funding Type

PhD Type

Neuropeptides are key mediators in many biological functions and understanding their interaction with target proteins is fundamental to unravel the underlying mechanism of diseases.
  Fostering development of ‘smart’, responsive therapeutics against cancer-related microRNAs.
  Dr E Bichenkova, Prof D Clarke, Dr H Aojula
Applications accepted all year round

Funding Type

PhD Type

Short functional non-coding microRNAs are implicated in many types of cancer, and thus can be used as biological targets for development of more selective and powerful anticancer therapies.
  Mechanisms of Cancer Stem Cell Survival, Metastasis Formation and Immune Evasion in Cancer
  Dr D Widera
Applications accepted all year round

Funding Type

PhD Type

Recent research suggests that cancer cells within a tumour represent a highly heterogeneous cell population. In particular many tumours contain small percentage of cells that share several characteristics with stem cells.
  Novel strategies for the diagnosis and treatment of snakebites
  Dr S Vaiyapuri
Applications accepted all year round

Funding Type

PhD Type

Snakebites represent a major neglected tropical disease affecting several million people worldwide and resulting in as many as 150000 deaths each year.
  Structure based design of angiotensin-converting enzyme (from Anopheles gambiae) inhibitors as mosquitocides
  Prof K R Acharya
Applications accepted all year round

Funding Type

PhD Type

The mosquitoes of the Anopheles and Aedes genus are some of the most deadly insects to humans because of their effectiveness as vectors of malaria and a range of arboviruses, including yellow fever, dengue, chikungunya, West Nile and zika.
  MRC DTP 4 Year PhD Programme: Targeting E3 ubiquitin ligases with small molecules
  Prof A Ciulli, Dr S Virdee
Application Deadline: 13 March 2020

Funding Type

PhD Type

This project is offered as part of the University of Dundee 4-year MRC DTP Programme “Quantitative and Interdisciplinary approaches to biomedical science”.
  Structural insights into ligand binding and channel gating in ATP-gated P2X7 receptor
  Research Group: School of Biomedical Sciences
  Dr L H Jiang, Dr S Muench
Applications accepted all year round

Funding Type

PhD Type

P2X7 receptor, belonging to the ATP-gated ion channel P2X receptor family, exhibits distinct functional and pharmacological properties that are crucial for its role in innate immunity and inflammatory diseases and cancers (Jiang et al., 2013; Caseley et al., 2014; Roger et al., 2014; Wei et al., 2018).
  Molecular analysis of the dynamic sulfotyrosine proteome
  Prof C E Eyers, Prof P Eyers, Dr A R Jones
Applications accepted all year round

Funding Type

PhD Type

The survival of an organism depends upon the ability of different cell types to communicate with each other by assembling the correct complexes of proteins at the correct time in the correct place.
  A mechanistic understanding of allosteric regulation of neuronal sodium-activated potassium channels
  Research Group: BBSRC White Rose DTP
  Dr J D Lippiat, Dr S Muench, Dr A Kalli
Applications accepted all year round

Funding Type

PhD Type

The sodium-activated potassium channel KNa1.1 (KCNT1, Slack, Slo2.2) is found in neurons and couples sodium influx to excitability.
  TRPM2 channel mechanism of neuroinflammation and neurodegeneration in Alzheimer’s disease
  Research Group: School of Biomedical Sciences
  Dr L H Jiang, Dr I Wood
Applications accepted all year round

Funding Type

PhD Type

Alzheimer’s disease (AD) is the most common cause of dementia and also a major cause of morbidity and mortality. Currently, there is no effective therapeutics to treat or slow the disease progress.
  Integrating mass spectrometry metabolomics, imaging and bioinformatics to develop physiology-based kinetic models for chemical safety science
  Prof M Viant, Dr B Campos, Dr C Rivetti, Dr I Sorrell
Application Deadline: 1 April 2020

Funding Type

PhD Type

**If you are interested in this studentship, it is vital to contact Professor Mark Viant prior to applying with a copy of your CV.
  Ion channel regulation in models of neurodegeneration
  Dr M Dallas, Prof G J Stephens, Dr A Bithell
Applications accepted all year round

Funding Type

PhD Type

Ion channels are important regulators of cellular physiology. There is now growing awareness that these proteins are invovled in pathological states, with relation to neurodegeneration voltage-gated potassium and voltage-gated calicum channels have been implicated.
  The effect of omega-3 polyunsaturated fatty acids (n-3 PUFA, “fish oils”), on vascular and potassium channel function
  Dr A McNeish, Dr G Cottrell, Dr F Tamagnini
Applications accepted all year round

Funding Type

PhD Type

There is a large body of evidence that consumption of oily fish or supplementation of fish oils leads to improvements in cardiovascular heath (as well as other health benefits including anti-inflammatory and anti-cancer effects).
  (WIS) Deciphering escape from senescence in vivo
  Prof P Townsend, Prof A D Whetton
Application Deadline: 6 March 2020

Funding Type

PhD Type

Senescence is a dynamic cellular state characterised by a prolonged and generally irreversible cell-cycle arrest that promotes tissue remodelling but it can also have detrimental implications on regenerative capacities of tissues and conduce to inflammation and the progression of ageing-related disease including cancer.
  Development of unique calcium channel pharmacological modulators
  Prof G Monteith, Dr B Ross
Application Deadline: 31 March 2020

Funding Type

PhD Type

This PhD project aims to develop isoform-specific modulators of a family of calcium permeable ion channels.
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