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Pharmacology / Toxicology (pharmacology) PhD Projects, Programs & Scholarships

We have 53 Pharmacology / Toxicology (pharmacology) PhD Projects, Programs & Scholarships

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  AstraZeneca/Pharmacology 4 year PhD studentship

Funding Type

PhD Type

Applications are invited for 4-year PhD studentship funded by AstraZeneca and the Department of Pharmacology. The student will be working on collaborative projects co-led by departmental supervisors and AstraZeneca scientists.
  AstraZeneca/Pharmacology 4 year PhD studentship

Funding Type

PhD Type

Applications are invited for 4-year PhD studentship funded by AstraZeneca and the Department of Pharmacology. The student will be working on collaborative projects co-led by departmental supervisors and AstraZeneca scientists.
  P2X receptors in the peripheral nervous system: molecular pharmacology (FOUNTAINSU20SF)
  Dr S Fountain
Application Deadline: 31 May 2020

Funding Type

PhD Type

P2X receptors are ligand-gated ion channels activated by extracellular adenosine 5’-triphosphate (ATP). In the peripheral nervous system (PNS), ATP is a neurotransmitter acting in both autonomic and sensory nerve control of body tissue function and homeostasis.
  Molecular Pharmacology of N-Methyl-D-aspartate glutamate receptors
  Dr P Chen
Applications accepted all year round

Funding Type

PhD Type

Fast neuronal communication at synaptic contacts relies on neurotransmitter release from the presynaptic terminal and the majority of excitatory neurotransmission within the mammalian central nervous system is mediated by the neurotransmitter glutamate.
  PhD in Chemical Biology -- Neuropeptide Research -- University of Vienna
  Prof M Muttenthaler
Applications accepted all year round

Funding Type

PhD Type

Neuropeptides are key mediators in many biological functions and understanding their interaction with target proteins is fundamental to unravel the underlying mechanism of diseases.
  SWBio DTP PhD project: Role of microRNAs in regulating sex differences in stress responsive neurocircuitry across the lifespan
  Prof M Lindsay, Dr S J Bailey
Application Deadline: 2 December 2019

Funding Type

PhD Type

This project is one of a number that are in competition for funding from the South West Biosciences Doctoral Training Partnership (SWBio DTP).
  Neuropeptide Research - PhD Opportunity at a World Class Institution
  Assoc Prof M Muttenthaler, Assoc Prof I Vetter
Applications accepted all year round

Funding Type

PhD Type

We are seeking talented and highly motivated PhD candidates for the following multidisciplinary project. Neuropeptides are key mediators in many biological functions and understanding their interaction with target proteins is fundamental to unravel the underlying mechanism of diseases.
  Quantitative Allele-Specific Proteomics in Drug Metabolism and Disposition
  Dr J Barber, Dr B Achour, Prof A Rostami
Applications accepted all year round

Funding Type

PhD Type

The effective dose of a drug is subject to considerable inter-individual variation because the enzymes that metabolise drugs and the proteins that transport them in and out of cells exist, in many cases, in different polymorphic forms and are expressed in varying concentration.
  Targeting ageing: Genes and compounds with pro-longevity, health-preserving effects
  Dr JP de Magalhaes
Applications accepted all year round

Funding Type

PhD Type

Ageing is arguably the major biomedical challenge of the 21st century. In model organisms, the process of ageing can be manipulated by both genetic manipulations and dietary interventions.
  MASTERS BY RESEARCH PROJECT: Can we improve patient outcomes by providing a more personalized approach to antiplatelet therapies?
  Dr S Mundell
Applications accepted all year round

Funding Type

PhD Type

Start 23 September 2019. This MSc by Research is a laboratory-based project which offers the exciting opportunity to spend 1 year in one of our State-of-the-Art laboratories (plus 1 year thesis writing) at the University of Bristol and experience life as a researcher.
  GW4 BioMed MRC DTP PhD studentship: Development of a cancer-on-a-chip device to study the role of insulin-like growth factor binding protein-6 and immune cell tumour infiltration in breast cancer
  Dr U Jungwirth
Application Deadline: 25 November 2019

Funding Type

PhD Type

This project is one of a number that are in competition for funding from the ‘GW4 BioMed MRC Doctoral Training Partnership’ which is offering up to 18 studentships for entry in September 2020.
  GW4 BioMed MRC DTP PhD studentship: Structure of ART Toxins: understanding toxicity through host receptor interactions
  Prof R Mrsny, Dr G Masuyer
Application Deadline: 25 November 2019

Funding Type

PhD Type

This project is one of a number that are in competition for funding from the ‘GW4 BioMed MRC Doctoral Training Partnership’ which is offering up to 18 studentships for entry in September 2020.
  EASTBIO: Development of inducible protein targeting to regulate G-protein-coupled receptor function.
  Dr J Hislop, Dr G Sapkota
Application Deadline: 5 January 2020

Funding Type

PhD Type

Supervisors. Dr James Hislop (University of Aberdeen). https://www.abdn.ac.uk/people/james.hislop. Dr Gopal Sapkota (University of Dundee).
  UCL-Birkbeck MRC Doctoral Training Programme across 4 strategic themes

Funding Type

PhD Type

The UCL-Birkbeck MRC Doctoral Training Programme provides state-of-the-art PhD training across four strategic themes. Fundamental mechanisms of disease.
  Open PhD positions - IMPRS for Heart and Lung Research

Funding Type

PhD Type

The International Max Planck Research School for Heart and Lung Research (IMPRS-HLR) offers up to ten positions to talented and enthusiastic students holding a relevant Master‘s degree.
  Fully-funded North West Cancer Research (NWCR) Centre PhD Studentship

Funding Type

PhD Type

The NWCR Centre comprises a network of research groups from across the north west of England who work on basic and translational aspects of cancer biology and treatment.
  Assessing the Behaviour of Endotoxin in Biopharmaceutical Formulations: towards creating improved medicines
  Dr A Golovanov
Application Deadline: 15 November 2019

Funding Type

PhD Type

Supervisors. Dr Alexander Golovanov (The University of Manchester) and Dr Adrian Podmore (AstraZeneca). Biopharmaceuticals are the fastest-growing type of treatments for wide range of diseases, with enormous potential for personalised medicine.
  (MRC DTP) Model-based precision dosing of antibiotics in critically ill patients
  Dr K Ogungbenro, Dr T Felton
Application Deadline: 15 November 2019

Funding Type

PhD Type

Community-acquired pneumonia (CAP) is a leading cause of morbidity and mortality in adults and children worldwide1. In the UK, CAP accounts for over 100,000 hospital admissions annually.
  Analysing the factors that regulate expression of blood-brain barrier drug transporter proteins
  Dr J L Penny, Dr C Demonacos
Applications accepted all year round

Funding Type

PhD Type

In order to treat diseases associated with the central nervous system (CNS), e.g. cancer, Parkinson’s disease, depression, it is essential for therapeutic drugs to be able to penetrate into the brain.
  In vitro assessment of drug sequestration into lysosomes and in silico prediction of implications for drug disposition and therapeutic efficacy
  Dr A Galetin, Dr D Hallifax
Applications accepted all year round

Funding Type

PhD Type

Intracellular concentration of a drug is an important determinant of its efficacy, toxicity, and potential drug-drug interactions [1].
  Investigating the role of bioactive lipids in skin health
  Prof A Nicolaou, Prof C A O'Neill
Applications accepted all year round

Funding Type

PhD Type

Human skin depends on systemic provision of fatty acids that are important to maintain the integrity of the epidermal barrier as well as to support the associated immune and inflammatory reactions.
  Targeting ERK5 to enhance the DNA damage response to radiotherapy and chemotherapy
  Dr K Finegan, Dr C Demonacos
Applications accepted all year round

Funding Type

PhD Type

ERK5 is a signalling protein that enables cells to transduce extracellular signals into responses. It is expressed in all tissues and is up-regulated in tumours.
  UCL-Birkbeck MRC Doctoral Training Programme across 4 strategic themes

Funding Type

PhD Type

The UCL-Birkbeck MRC Doctoral Training Programme provides state-of-the-art PhD training across four strategic themes. Fundamental mechanisms of disease.
  Design, synthesis and evaluation of novel polysialyltransferase inhibitors as anti- metastatic agents
  Research Group: Institute of Cancer Therapeutics
  Dr R Falconer, Dr S Shnyder
Applications accepted all year round

Funding Type

PhD Type

Polysialic acid plays an essential role in neuronal development, but by adulthood is absent from the human body. Its biosynthesis is regulated by two polysialyltransferases (polySTs).
  Design, synthesis and evaluation of protease-activated anti-cancer prodrugs
  Research Group: Institute of Cancer Therapeutics
  Dr R Falconer, Prof P Loadman
Applications accepted all year round

Funding Type

PhD Type

Matrix metalloproteinases (MMPs) are a family of endoproteases that are overexpressed in tumours and play crucial roles in many tumourigenic processes, not least tumour invasion and angiogenesis.
  Impact of RhoA deregulation on smooth muscle cell phenotypic dysfunction in Type 2 diabetes
  Research Group: Chemistry and Biosciences
  Dr K Riches-Suman
Applications accepted all year round

Funding Type

PhD Type

Type 2 diabetes (T2D) is an escalating healthcare burden. It inflicts significant physical and emotional distress on patients and their carers, and treatment of T2D and its complications accounts for ~10% of the entire NHS budget.
  Polysialyltransferases as a target in metastatic cancer
  Research Group: Institute of Cancer Therapeutics
  Dr R Falconer, Dr S Shnyder
Applications accepted all year round

Funding Type

PhD Type

Polysialic acid plays an essential role in neuronal development, but by adulthood is absent from the human body. Its biosynthesis is regulated by two polysialyltransferases.
  Therapeutic resolution of pulmonary arterial hypertension (PAH) by natural products
  Research Group: Pharmacology and Experimental Therapeutics
  Dr T Nasim, Prof C Wright
Applications accepted all year round

Funding Type

PhD Type

Pulmonary arterial hypertension (PAH) is a devastating cardiovascular disorder which, if left untreated, leads to heart failure and death.
  Identification of novel glucose-dependent alterations responsible for vascular dysfunction in Type 2 diabetes.
  Prof Tim Palmer, Dr R Sturmey
Application Deadline: 31 March 2020

Funding Type

PhD Type

Diabetes is a growing global healthcare problem. The majority of people living with diabetes have Type 2 diabetes mellitus (T2DM), characterised by a resistance of the body to the action of insulin.
  Modulation of platelet-mediated innate immune responses in chronic lymphocytic leukaemia
  Dr M Arman
Application Deadline: 31 March 2020

Funding Type

PhD Type

Chronic lymphocytic leukaemia (CLL) is the most common form of leukaemia in the Western World. B-cell receptor-induced intracellular signals are critical for the survival of leukaemia cells and disruption of this pathway by the Bruton’s tyrosine kinase (Btk) inhibitor ibrutinib is a highly effective CLL therapy.
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