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We have 180 Pharmacology PhD Projects, Programmes & Scholarships for Self-funded Students

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Pharmacology PhD Projects, Programmes & Scholarships for Self-funded Students

We have 180 Pharmacology PhD Projects, Programmes & Scholarships for Self-funded Students

Neurovascular coupling in cerebral hypoperfusion

There are almost a million people living with dementia in the UK. Most of these cases comprise Alzheimer’s Disease (AD), vascular dementia (VaD) or, as is increasingly recognised, a mixed picture phenotype with evidence of the two conditions co-existent in the same patient. Read more

Drug metabolism - prediction, detection, and isolation

Electrosynthesis (ES) is a green methodology for preparing and interpreting drug metabolites linked to toxicology. ES describes the synthesis of chemical compounds in an electrochemical cell. Read more

Discovering off-target side-effects and drug repurposing candidates using expression perturbation data

The MRC Integrative Epidemiology Unit at the University of Bristol is the leading group for the development and application of causal analysis and evidence triangulation in health research to improve lives. Read more

Development of miRNAs as a new therapeutic tool in the treatment of cardiovascular diseases

Ischemic heart diseases and their pathological consequences belong to the leading causes of death worldwide. In the acute treatment of myocardial ischemia one of the most important tasks is the restoration of the tissue perfusion. Read more

Application and development of bioinformatics and network theory methods in cardiovascular disease research and pharmacovigilance

To be able to discover novel drug targets we aim to develop software based on network theoretic approaches that are capable to identify mediators and pathways involved in the pathomechanism of various cardiovascular diseases by the analysis of datasets assessed with high throughput molecular biological techniques (e.g. Read more

(MRC DTP CASE) Understanding how tumour associated macrophages control the tumour immune landscape in NF2-Schwannomatosis

Type 2 Neurofibromatosis (NF2), now referred to as NF2-Schwannomatosis (or NF2-SWN), is a rare autosomal dominant tumour pre-disposition syndrome characterised by growth of typically benign tumours throughout the nervous system. Read more

Self-funded PhD- Interplay between environmental toxins and cancer predisposition

Cancer arises in part from intrinsic molecular and cellular alterations. For instance, loss of major DNA damage response genes such as BRCA1/2 has long been known to predispose individuals to multiple cancer types. Read more

Funded PhD - Determining the genetic and circadian basis of bipolar disorder

This project will be part of the University of Bristol - University of Kent Cotutelle Programme. It will be jointly supervised by Prof James Hodge (http://www.bristol.ac.uk/phys-pharm-neuro/people-new/hodge/) and Dr Alice French at the University of Bristol, and by Prof Gurprit Lall at University of Kent. Read more

Investigation of short-term effects of colchicine on blood proteins using proteomics

The anti-inflammatory medication colchicine has been shown to significantly improve cardiovascular outcomes post heart attack and in chronic heart disease patient groups, suggesting it may be a suitable candidate for repurposing in cardiovascular diseases. Read more

Lessening Health Inequalities in Type 2 Diabetes Through Innovative Drug Repurposing

Most older type 2 diabetes (T2D) drugs were developed through pre-clinical studies and then trials that model T2D as it is experienced by older white people (1). Read more

MScR: Probing the projections of different types of dopamine neurons

What makes one neuron different from another? How can we define different “types” of cells? Are cell types important?. In Parkinson’s disease some dopamine neurons seem to be more vulnerable to neurodegeneration. Read more

Vascularisation of tumour organoids for mechanistic and drug development

Gliomas such as are the most common form of brain tumour, a subset Glioblastoma (GBM) are devastating adult brain cancer with high rates of recurrence and treatment resistance. Read more

Investigating how dormant senescent cells can drive drug-resistance following chemotherapy

Most anti-cancer chemotherapeutics work by inducing DNA damage and arresting the cell cycle in either G1 or G2 phase. A frequent outcome of this arrest is that cells exit the cell cycle into a state known as senescence. Read more

Using chemical-genetics to inhibit and characterise “undruggable” enzymes

The ability to inhibit kinases with small molecule drugs has transformed our understanding of signalling networks. It has allowed us to define the substrates and processes that each kinase controls, and to map how these enzymes cooperate within signalling pathways. Read more

Dissecting behaviourally relevant feedback microcircuits in the brain

Interactions between distinct neural circuits in the brain help in sensory-guided perceptual decisions. We have recently reported that task/context-switching behaviour is dependent upon specific populations of neurons in the frontal cortex which encode and convey rule-related information (Banerjee et al. Read more

Fully Funded PhD Scholarship in Biomaterials Synthesis and Cartilage Tissue Engineering

Application(s) are invited from suitably qualified candidates for full-time funded PhD scholarship starting in September, 2024 affiliated to the School of Medicine at the University of Galway. Read more

Investigations into the protective actions of CBD in the early synaptic deficits in dementia.

Accumulation of hyper-phosphorylated tau is a key event in Alzheimer’s disease (AD). Aberrant changes in tau cause synaptic abnormalities and cognitive deficits in early AD. Read more

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