This is a unique and exciting opportunity to learn new skills in artificial intelligence and ageing biology. You will combine patch-clamp electrophysiology with cutting edge machine learning to predict and understand how cells in the heart age.
Ageing is the chief biomedical challenge of the 21st century, yet it remains a major puzzle of biology. Although it is clear that the process of ageing has a strong genetic component, much work remains to elucidate how the genome regulates ageing.
Heparan sulphates (HS) are complex sulphated polysaccharides expressed at the cell surface. They are essential co-receptors for many proteins, most notably many signalling growth factors, and they act as dynamic regulators of protein function.
Epilepsy is a common neurological disorder that has a major impact on patient mortality, morbidity and quality of life. Clinical management remains extremely problematic, held back both by diagnostic and treatment limitations.
Dr M Cross, Prof J Schneider, Prof H Poptani, Dr B Wilm
21 January 2019
Cardiovascular disease (CVD) is the leading cause of death in the western world. The incidence and prevalence of CVD is highest among the elderly due to the deleterious effects of advancing age on the heart and blood vessels1.
Supervisors. Dr S Pushpakom. Prof M Bushell. Prof Sir M Pirmohamed. Background. Diabetes, obesity and cardiovascular disease (collectively called cardiometabolic disease) remain a major public health problem worldwide.