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University of Reading Pharmacology / Toxicology PhD Projects, Programs & Scholarships

We have 8 University of Reading Pharmacology / Toxicology PhD Projects, Programs & Scholarships

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Showing 1 to 8 of 8
  Using CRISPR in iPS cells to modify platelet function
  Dr C.E. Hughes
Applications accepted all year round
"Platelets are the small cells in the blood whose job it is to prevent bleeding. Under normal conditions, when they encounter a damaged blood vessel they become activated and form a thrombus.
  Functional Selectivity and the Regulation of Receptor-Activated Signaling Pathways
  Dr G Cottrell, Dr D Widera, Dr S Amadesi, Dr A McNeish
Applications accepted all year round
The molecular mechanisms that regulate receptors and receptor-activated signaling pathways in the cardiovascular and nervous systems are complex.
  Investigation of the critical roles of platelets at the interface between thrombosis and inflammation in order to develop improved therapeutic strategies for the treatment and/or prevention of cardiovascular diseases
  Dr S Vaiyapuri
Applications accepted all year round
Platelets (small circulating blood cells) are involved in blood clotting to prevent excessive bleeding, however, their inappropriate activation under pathological conditions leads to thrombosis resulting in major cardiovascular diseases such as heart attack and stroke.
  Ion channel regulation in models of neurodegeneration
  Dr M Dallas, Prof G J Stephens, Dr A Bithell
Applications accepted all year round
Ion channels are important regulators of cellular physiology. There is now growing awareness that these proteins are invovled in pathological states, with relation to neurodegeneration voltage-gated potassium and voltage-gated calicum channels have been implicated.
  Mechanisms of Cancer Stem Cell Survival, Metastasis Formation and Immune Evasion in Cancer
  Dr D Widera
Applications accepted all year round
Recent research suggests that cancer cells within a tumour represent a highly heterogeneous cell population. In particular many tumours contain small percentage of cells that share several characteristics with stem cells.
  Neurovascular coupling in epilepsy/seizure
  Dr A McNeish, Dr G Cottrell, Dr B J Whalley, Dr M Dallas
Applications accepted all year round
Epilepsy is a serious and debilitating condition characterised by seizure affecting over 100 million people worldwide. In addition to epilepsy, seizure is a symptom associated with over 50% of brain diseases including major neurodegenerative diseases such as vascular dementia and stroke.
  Novel strategies for the diagnosis and treatment of snakebites
  Dr S Vaiyapuri
Applications accepted all year round
Snakebites represent a major neglected tropical disease affecting several million people worldwide and resulting in as many as 150000 deaths each year.
  The effect of omega-3 poly unsaturated fatty acids (n-3 PUFA, “fish oils”), on vascular function
  Dr A McNeish, Dr G Cottrell, Dr B J Whalley, Dr M Dallas
Applications accepted all year round
There is a large body of evidence that consumption of oily fish or supplementation of fish oils leads to improvements in cardiovascular heath (as well as other health benefits including anti-inflammatory and anti-cancer effects).
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