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Pharmacology PhD Projects, Programmes & Scholarships

We have 162 Pharmacology PhD Projects, Programmes & Scholarships

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We have 162 Pharmacology PhD Projects, Programmes & Scholarships

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Natural toxins and their synthetic analogues as tools to study ion channels and as potential drugs and pesticides

The project will use a combination of electrophysiological techniques such as voltage-clamp and patch-clamp with molecular biology and protein expression to understand how natural toxins and their synthetic analogues act on ion channels in the nervous system. Read more

Probing Viral Receptor-Glycan Interactions using Polyvalent Multifunctional Glycan-Nanoparticle

  Research Group: School of Chemistry
Multivalent viral receptor-glycan interactions are central to viral infection and immune response regulation. However, the underpinning structural mechanisms are often poorly understood, due to a lack of effective probes for such complex, multimeric and flexible proteins. Read more

Neuroinflammation, glial cell dysfunction & neurodegenerative diseases

Neurodegenerative disorders, such as Alzheimer’s disease, are often associated with chronic neuroinflammation and glial cell dysfunction that acts to exacerbate neuronal damage and loss of synapses. Read more

Examining the mechanisms that cause cardiovascular disease by studying the heart or adipose tissue

Heart failure has a serious impact on our society and once diagnosed has a poor survival rate. In the United Kingdom, there are about 1.5 million people living with the after-effects of a heart attack. Read more

Understanding the Impacts of Inhaled Particulate Matter on Neurological Health

The biological processes underlying the development of dementia and other neurodegenerative disorders are complex and not fully understood, but accumulating evidence has demonstrated that exposure to air pollution, especially airborne particles, is a potentially important environmental risk factor. Read more

Synthetic transition metal catalysts for the treatment of cancer

Working the interfaces of chemical catalysis, analytical chemistry, cellular biology, pharmacology and medicine, this project provides unique interdisciplinary training in the skills required for the development of a pre-clinical metal-based therapy. Read more

A biologic drug blocking ROR2 for disease modification in osteoarthritis

We reported that silencing the WNT receptor ROR2 results in protection from cartilage breakdown and rapid pain relief in a murine model of osteoarthritis and in chondrogenesis in vitro and in vivo with human osteoarthritic chondrocytes (Thorup et al. Read more

Polmorphisms in cytosolic drug metabolising enzymes: a combined proteomics and modelling approach to clinical impact

Cytosolic drug metabolising enzymes such as aldehyde oxidase play a pivotal role in metabolism of drugs. However, research into cytosolic enzymes has been relatively neglected in comparison with membrane bound enzymes such as cytochrome P450 (CYP) and uridine 5’-glucuronosyltransferases (UGTs). Read more

Comparative Effectiveness of Treatments for Osteoarthritis

About the research project. Osteoarthritis is a common joint disorder for which there is no cure. Recommendations for the symptomatic management of osteoarthritis include exercise, weight control, education, and self-management as the core treatment option. Read more

Development of DNA repair therapeutics to overcome cancer resistance to chemotherapy

  Research Group: Institute of Cancer Therapeutics
Reduced oxygen supply (hypoxia) is a common feature of cells distant to blood vessels in most solid cancers. It reduces the effectiveness of chemotherapy and promotes cancer aggressiveness and spread. Read more

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