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University of Birmingham Biochemistry PhD Projects

We have 16 University of Birmingham Biochemistry PhD Projects

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Showing 1 to 15 of 16
  Regulation of host cell DNA damage response pathways by adenovirus
  Dr A S Turnell, Dr C McCabe
Applications accepted all year round

Funding Type

PhD Type

Human adenoviruses are small non-enveloped viruses with a linear, double-stranded DNA genome. Adenovirus has long served as a faithful model for dissecting the molecular basis of key cellular signalling pathways that regulate fundamental biological processes such as cell growth, cell differentiation and cell death.
  Analysing immune responses to metastatic ovarian tumours to identify therapeutic targets
  Dr J H Caamano, Dr D Withers
Applications accepted all year round

Funding Type

PhD Type

Research interests/description of main research theme. Ovarian cancer remains the most lethal gynaecological malignancy for women over 50 years old (1).
  Investigating how ovarian tumours avoid immune responses in cancer patients
  Dr J H Caamano, Dr D Withers
Applications accepted all year round

Funding Type

PhD Type

Research interests/description of main research theme. Ovarian cancer remains the most lethal gynaecological malignancy for women over 50 years old (1).
  Establishing a rationale for FGF23 modulation as a therapy in the critically ill patient
  Dr D Parekh, Prof D Thickett, Dr A Scott
Application Deadline: 1 September 2020

Funding Type

PhD Type

Research interests/description of main research theme. Everyone suffers at least one critical illness during their life. In the UK, 160,000 critically ill patients are admitted annually to intensive care units (ICU).
  The role of Efflux in Antibiotic Resistance of Clinically Relevant Pathogens
  Dr J Blair
Applications accepted all year round

Funding Type

PhD Type

Antibiotics underpin all of modern medicine; they are used to treat bacterial infections, and to prevent infections after surgery and in patients with a suppressed immune system such as those undergoing cancer chemotherapy or organ transplantation.
  The role of pore-forming bacterial proteins in pneumonia and meningitis
  Prof T J Mitchell, Dr M Tomlinson
Applications accepted all year round

Funding Type

PhD Type

The bacterium Streptococcus pneumoniae (the pneumococcus) is carried in the nasopharynx of most children and some adults without causing disease.
  Build and destroy: investigating targeted protein degradation in plant development and stress-response
  Dr D Gibbs
Applications accepted all year round

Funding Type

PhD Type

In order to effectively co-ordinate their growth and development, plants need to be able to respond to changes in their environment, whether it is adapting to the seasons or coping with stresses.
  Determining novel molecular regulators of necrosis controlling premature cell death
  Dr Y Fan
Applications accepted all year round

Funding Type

PhD Type

Necrosis, a form of premature cell death, is frequently caused by excessive insults such as trauma, infection and toxins. It has been implicated in many human diseases including cancer, neurodegenerative disorders and inflammatory diseases.
  Genetic analysis of the bacterial translocation machinery
  Dr D Huber
Applications accepted all year round

Funding Type

PhD Type

Every subcellular compartment in a cell contains proteins, and yet all of these proteins are initially synthesised in the same compartment.
  Molecular Cookie Cutters: Cutting Edge Drug Discovery using G-Protein Coupled Receptors
  Prof T R Dafforn
Application Deadline: 7 June 2020

Funding Type

PhD Type

Membrane proteins represent 30-40% of the cellular proteome and carry out a wide range of fundamental biological process. These include sensing the outside world, helping maintain cellular structure and homeostasis.
  Novel viscosupplementation formulation for treatment of arthritis
  Dr Z Zhang
Application Deadline: 1 September 2020

Funding Type

PhD Type

Osteoarthritis of the knee is one of the leading causes of disability. It is common for medical professionals to recommend patients to use viscosupplementation, injection of artificial lubricant into arthritic joints, as a non-surgical intervention, for treatment of early stage arthritis.
  Computational and Polymer Sciences to Engineer Microbial Physiology
  Dr S Jabbari, Dr F Fernandez-Trillo
Application Deadline: 31 July 2020

Funding Type

PhD Type

Mathematical modelling and statistical inference are key tools in understanding the life sciences. In this project, we will develop differential equation models and apply statistical inference techniques to understand how polymers can be engineered to be of practical use in microbiology.
  Development of precise polymer nanoparticles
  Prof R O'Reilly
Applications accepted all year round

Funding Type

PhD Type

This studentship is only open to UK or EU nationals. The successful applicant should possess a good (1st or 2.1 UK or equivalent) degree in chemistry from a well-regarded institution.
  Engineering Microbial Physiology through Polymer and Computational Sciences
  Research Group: Materials Chemistry
  Dr F Fernandez-Trillo, Dr S Jabbari
Application Deadline: 31 July 2020

Funding Type

PhD Type

Recently, there has been an increasing use of polymers to interface with bacteria and other microorganisms, either to treat microbial infections, to prevent and control biofilm formation, or as a platform to grow and maintain microbial cultures for biotechnology.
  Investigating Potential Applications of Functional DNA-based Materials and Sensors
  Prof J Tucker
Applications accepted all year round

Funding Type

PhD Type

This PhD project falls into the areas of supramolecular chemistry, chemical biology and DNA nanotechnology and involves the preparation and study of DNA-based materials and sensors.
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