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Bioinformatics PhD Research Projects

We have 54 Bioinformatics PhD Research Projects

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We have 54 Bioinformatics PhD Research Projects

Evolutionary game theory and population dynamics

Evolutionary Game Theory (EGT) [MSP73] has proven to be a powerful and versatile mathematical framework for the modelling and analysis of complex biological (and economical) systems whenever there is frequency dependent selection. Read more

Genome-wide translational responses to stress

We are interested in gene regulation in responses to stress, using both simple model organisms, human and plant pathogens. Cells respond to stress conditions by launching complex programs of gene expression, both transcriptional and posttranscriptional, and which are often closely linked with each other. Read more

Does SUMO protease SENP3 play a role in α-synuclein aggregation and toxicity?

Pathogenic causes for progressive loss of dopaminergic neurons along with protein aggregates termed Lewy bodies in the substantia nigra in (SN) Parkinson’s disease (PD) are not yet understood. Read more

Ankle moment contribution in everyday tasks: effects of ageing

  Research Group: Medical Engineering
There is a fall on stairs every 90 seconds in the UK, and an estimated 250,000 non-fatal accidents which are serious enough to merit a trip to A&E. Read more

Discovery and Development of Biocatalytic Solutions to Mitigate Microplastic Pollution

  Research Group: Chemistry and Biosciences
Plastic contamination is a great ecological disaster facing modern society; a burden overwhelmingly heaped on the least economically developed countries. Read more

Exploiting aberrated DNA damage signalling signatures to identify personalised combination therapies for paediatric cancer treatment

  Research Group: Translational Tumour Biology
More than 140 children with cancer die in Australia each year due to the occurrence of resistance to traditional chemotherapy. To improve overall survival rates for high-risk paediatric cancer patients, treatment developments have been shifted to personalised approaches. Read more

Immune Profiling and Immunotherapy for High-Risk Paediatric Sarcomas

  Research Group: Translational Tumour Biology
Sarcomas are a diverse group of connective tissue tumours that account for ~10% of childhood cancers. However, they are relatively understudied and poorly understood. Read more

Explaining unexplained drug responses in childhood sarcomas

  Research Group: Translational Tumour Biology
Despite aggressive treatments, survival of young, high-risk sarcoma patients is poor and side-effects are frequent. No targeted treatment is available, underlining the unmet need for better and less toxic treatments. Read more

Integrative data analysis: from novel biomarker-drug response associations to predicting effective drug combinations

  Research Group: Translational Tumour Biology
More than 140 children with cancer die in Australia each year due to the occurrence of resistance to traditional chemotherapy. To improve overall survival rates for high-risk paediatric cancer patients, the Children’s Cancer Institute initiated the Zero Childhood Cancer national personalised medicine trial (PRISM). Read more

In vitro immunotherapy testing: towards next level personalised treatment identification

  Research Group: Translational Tumour Biology
Around 200 children are diagnosed with high-risk cancer in Australia each year. Over 140 of these children still die due to the occurrence of resistance to traditional chemotherapy. Read more

Tailored PROTACs to target the undruggable in paediatric cancer

  Research Group: Translational Tumour Biology
Around 200 children are diagnosed with high-risk cancer in Australia each year. Over 140 of these children still die due to the occurrence of resistance to traditional chemotherapy. Read more

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