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We have 27 University of Leeds Bioinformatics PhD Projects, Programmes & Scholarships

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University of Leeds Bioinformatics PhD Projects, Programmes & Scholarships

We have 27 University of Leeds Bioinformatics PhD Projects, Programmes & Scholarships

University of Leeds

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Control and inhibition of virus replication

University of Leeds Faculty of Biological Sciences
The Tuplin laboratory utilises a range of cutting-edge approaches to investigate how arboviruses - specifically Chikungunya, Dengue and Zika viruses - control replication and translation of their genomes through interactions between RNA structures, host cell proteins and non-coding RNA, and the potential of such RNA elements/interactions as novel therapeutic targets. Read more
 Supervisor: Dr A.K Tuplin
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Investigation of host-virus interactions

University of Leeds Faculty of Biological Sciences
The School of Molecular and Cellular Biology invites applications from prospective postgraduate researchers who wish to commence study for a PhD in the academic year 2024/25 in the area of molecular virology. Read more
 Supervisors: Dr M Stacey, Dr J N Barr
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Machine Learning and Molecular Modelling in Mass Spectrometry

University of Leeds Faculty of Biological Sciences
This PhD project will harness the power of computational modelling and machine learning (A.I.) to analyse data obtained by mass spectrometry experiments and predict structural characteristics of biomolecules and their interactions. Read more
 Supervisors: Prof F. Sobott, Dr A Kalli, Dr H Wang
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Manipulation of neuroimmune responses and behaviour by infectious agents

University of Leeds Faculty of Biological Sciences
This project is available exclusively to self-funded students who wish to commence study for a PhD in the academic year 2023/24. The project focuses on how infectious agents modify the individuals that they infect and how neuroimmune responses to infection moderate behaviour changes in warm-blooded animals and humans. Read more
 Supervisors: Dr G Mcconkey, Dr S Clapcote
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Elucidating the molecular mechanisms of intrinsic antibiotic resistance in bacterial pathogens

University of Leeds Faculty of Biological Sciences
Antibiotics make possible the treatment and cure of life-threatening bacterial infections and have added over a decade to the average human lifespan. Read more
 Supervisor: Prof A O'Neill
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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NIHR Leeds BRC: The role of target organs in initiation of autoimmunity in systemic lupus erythematosus

University of Leeds Faculty of Medicine and Health
Autoimmune diseases such as SLE have traditionally been understood to result from aberrant haematopoietic adaptive immune system that targets normal tissues such as the skin and joints. Read more
 Supervisor: Dr E Vital
 26 May 2024  PhD Research Project  Competition Funded PhD Project (UK Students Only)
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NIHR Leeds BRC: The microbiome and the promotion of bowel cancer: The key to understanding causation and prevention of this important disease

University of Leeds Faculty of Medicine and Health
Bowel cancer is the second commonest cause of cancer death in the UK and affects 1.9 million people annually worldwide. Its cause is still unknown but recent work by Wood et al. Read more
 Supervisors: Dr K Marks, Dr H Wood, Dr N West, Prof P Quirke
 26 May 2024  PhD Research Project  Competition Funded PhD Project (UK Students Only)
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NIHR Leeds BRC: Pre-clinical evaluation of novel regenerative medicine strategies for knee osteoarthritis

University of Leeds Faculty of Medicine and Health
Historically, articular cartilage was considered incapable of spontaneous repair.  However, biomechanical correction in osteoarthritis (OA) using high tibial osteotomy or joint distraction demonstrated the remarkable joint to regeneration by “merely” correcting joint alignment. Read more
 Supervisors: Prof H Pandit, Prof D McGonagle
 26 May 2024  PhD Research Project  Competition Funded PhD Project (UK Students Only)
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NIHR Leeds BRC: Multimodal predictive modelling of outcome in patients with gastrointestinal cancer

University of Leeds Faculty of Medicine and Health
Worldwide, cancer of the upper (oesophagus, stomach) and lower gastrointestinal (colon and rectum) tract is newly diagnosed in 3.6 million patients every year and 2.2 million patients die from this disease every year. Read more
 Supervisors: Dr H Grabsch, Dr N West, Dr D Magee
 26 May 2024  PhD Research Project  Competition Funded PhD Project (UK Students Only)
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NIHR Leeds BRC: Exploring the impact of 'hidden' antibiotic resistance

University of Leeds Faculty of Medicine and Health
Antibiotics make possible the treatment of life-threatening infections and have added over a decade to average human lifespan. Read more
 Supervisors: Prof A O'Neill, Dr K Davies, Dr J Sandoe
 26 May 2024  PhD Research Project  Competition Funded PhD Project (UK Students Only)
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Epigenetics and Cancer: Determining how Mistakes in V(D)J Recombination Trigger Leukaemias and Lymphomas

University of Leeds Faculty of Biological Sciences
V(D)J recombination is essential to produce an effective adaptive immune system but since the reaction involves breakage and rejoining of DNA, it is highly dangerous and errors have long been thought to lead to leukaemias and lymphomas. Read more
 Supervisor: Dr J Boyes
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Genetics: Investigating the functional effect of novel genes and genetic variants in malignant hyperthermia susceptibility using model systems

University of Leeds Faculty of Medicine and Health
Malignant hyperthermia (MH) is an inherited condition, where patients exposed to anaesthetic drugs are susceptible to a dramatic hyperthermic and hypermetabolic response that can contribute to a significant proportion of post-operative morbidity and deaths. Read more
 Supervisors: Prof P Hopkins, Dr M-A Shaw, Dr C Diggle
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Cancer: Characterization of EGFR signaling activated by the endothelium in the process of breast cancer metastasis to the brain

University of Leeds Faculty of Medicine and Health
The Epidermal Growth Factor Receptor (EGFR) is important in normal physiology regulating epithelial development and homeostasis. In cancer, deregulation resulting from mutation, amplification or transcriptional upregulation promotes tumorigenesis. Read more
 Supervisors: Dr G Mavria, Dr S Bell
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Haematology: Oncogenic reprogramming of immune cells; novel mechanism for drug resistance in leukaemia

University of Leeds Faculty of Medicine and Health
Under pathogenic challenges, cells of the haematopoietic system become epigenetically reprogrammed and establish immune memory. Read more
 Supervisor: Dr P Laslo
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Translational Medicine: Understanding the mechanism(s) of resistance to EPA to personalise therapy and improve outcome

University of Leeds Faculty of Medicine and Health
Advanced colorectal cancer (CRC) is the UK’s second most lethal cancer, with limited treatment options for unresectable metastatic tumours. Read more
 Supervisors: Dr MA Volpato, Prof M Hull
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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