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We have 27 University of Leeds Bioinformatics PhD Projects, Programmes & Scholarships

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University of Leeds Bioinformatics PhD Projects, Programmes & Scholarships

We have 27 University of Leeds Bioinformatics PhD Projects, Programmes & Scholarships

University of Leeds

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Control and inhibition of virus replication

University of Leeds Faculty of Biological Sciences
The Tuplin laboratory utilises a range of cutting-edge approaches to investigate how arboviruses - specifically Chikungunya, Dengue and Zika viruses - control replication and translation of their genomes through interactions between RNA structures, host cell proteins and non-coding RNA, and the potential of such RNA elements/interactions as novel therapeutic targets. Read more
 Supervisor: Dr A.K Tuplin
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Investigation of host-virus interactions

University of Leeds Faculty of Biological Sciences
The School of Molecular and Cellular Biology invites applications from prospective postgraduate researchers who wish to commence study for a PhD in the academic year 2024/25 in the area of molecular virology. Read more
 Supervisors: Dr M Stacey, Dr J N Barr
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Machine Learning and Molecular Modelling in Mass Spectrometry

University of Leeds Faculty of Biological Sciences
This PhD project will harness the power of computational modelling and machine learning (A.I.) to analyse data obtained by mass spectrometry experiments and predict structural characteristics of biomolecules and their interactions. Read more
 Supervisors: Prof F. Sobott, Dr A Kalli, Dr H Wang
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Manipulation of neuroimmune responses and behaviour by infectious agents

University of Leeds Faculty of Biological Sciences
This project is available exclusively to self-funded students who wish to commence study for a PhD in the academic year 2023/24. The project focuses on how infectious agents modify the individuals that they infect and how neuroimmune responses to infection moderate behaviour changes in warm-blooded animals and humans. Read more
 Supervisors: Dr G Mcconkey, Dr S Clapcote
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Elucidating the molecular mechanisms of intrinsic antibiotic resistance in bacterial pathogens

University of Leeds Faculty of Biological Sciences
Antibiotics make possible the treatment and cure of life-threatening bacterial infections and have added over a decade to the average human lifespan. Read more
 Supervisor: Prof A O'Neill
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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NIHR Leeds BRC: The role of target organs in initiation of autoimmunity in systemic lupus erythematosus

University of Leeds Faculty of Medicine and Health
Autoimmune diseases such as SLE have traditionally been understood to result from aberrant haematopoietic adaptive immune system that targets normal tissues such as the skin and joints. Read more
 Supervisor: Dr E Vital
 26 May 2024  PhD Research Project  Competition Funded PhD Project (UK Students Only)
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NIHR Leeds BRC: The microbiome and the promotion of bowel cancer: The key to understanding causation and prevention of this important disease

University of Leeds Faculty of Medicine and Health
Bowel cancer is the second commonest cause of cancer death in the UK and affects 1.9 million people annually worldwide. Its cause is still unknown but recent work by Wood et al. Read more
 Supervisors: Dr K Marks, Dr H Wood, Dr N West, Prof P Quirke
 26 May 2024  PhD Research Project  Competition Funded PhD Project (UK Students Only)
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NIHR Leeds BRC: Pre-clinical evaluation of novel regenerative medicine strategies for knee osteoarthritis

University of Leeds Faculty of Medicine and Health
Historically, articular cartilage was considered incapable of spontaneous repair.  However, biomechanical correction in osteoarthritis (OA) using high tibial osteotomy or joint distraction demonstrated the remarkable joint to regeneration by “merely” correcting joint alignment. Read more
 Supervisors: Prof H Pandit, Prof D McGonagle
 26 May 2024  PhD Research Project  Competition Funded PhD Project (UK Students Only)
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NIHR Leeds BRC: Multimodal predictive modelling of outcome in patients with gastrointestinal cancer

University of Leeds Faculty of Medicine and Health
Worldwide, cancer of the upper (oesophagus, stomach) and lower gastrointestinal (colon and rectum) tract is newly diagnosed in 3.6 million patients every year and 2.2 million patients die from this disease every year. Read more
 Supervisors: Dr H Grabsch, Dr N West, Dr D Magee
 26 May 2024  PhD Research Project  Competition Funded PhD Project (UK Students Only)
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NIHR Leeds BRC: Exploring the impact of 'hidden' antibiotic resistance

University of Leeds Faculty of Medicine and Health
Antibiotics make possible the treatment of life-threatening infections and have added over a decade to average human lifespan. Read more
 Supervisors: Prof A O'Neill, Dr K Davies, Dr J Sandoe
 26 May 2024  PhD Research Project  Competition Funded PhD Project (UK Students Only)
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Epigenetics and Cancer: Determining how Mistakes in V(D)J Recombination Trigger Leukaemias and Lymphomas

University of Leeds Faculty of Biological Sciences
V(D)J recombination is essential to produce an effective adaptive immune system but since the reaction involves breakage and rejoining of DNA, it is highly dangerous and errors have long been thought to lead to leukaemias and lymphomas. Read more
 Supervisor: Dr J Boyes
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Genetics: Investigating the functional effect of novel genes and genetic variants in malignant hyperthermia susceptibility using model systems

University of Leeds Faculty of Medicine and Health
Malignant hyperthermia (MH) is an inherited condition, where patients exposed to anaesthetic drugs are susceptible to a dramatic hyperthermic and hypermetabolic response that can contribute to a significant proportion of post-operative morbidity and deaths. Read more
 Supervisors: Prof P Hopkins, Dr M-A Shaw, Dr C Diggle
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Cancer: Characterization of EGFR signaling activated by the endothelium in the process of breast cancer metastasis to the brain

University of Leeds Faculty of Medicine and Health
The Epidermal Growth Factor Receptor (EGFR) is important in normal physiology regulating epithelial development and homeostasis. In cancer, deregulation resulting from mutation, amplification or transcriptional upregulation promotes tumorigenesis. Read more
 Supervisors: Dr G Mavria, Dr S Bell
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Haematology: Oncogenic reprogramming of immune cells; novel mechanism for drug resistance in leukaemia

University of Leeds Faculty of Medicine and Health
Under pathogenic challenges, cells of the haematopoietic system become epigenetically reprogrammed and establish immune memory. Read more
 Supervisor: Dr P Laslo
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Translational Medicine: Understanding the mechanism(s) of resistance to EPA to personalise therapy and improve outcome

University of Leeds Faculty of Medicine and Health
Advanced colorectal cancer (CRC) is the UK’s second most lethal cancer, with limited treatment options for unresectable metastatic tumours. Read more
 Supervisors: Dr MA Volpato, Prof M Hull
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Cancer Biology: The role of Wnt signaling in glioblastoma therapeutic resistance

University of Leeds Faculty of Medicine and Health
Glioblastoma is a deadly brain tumour treated with surgery, radiotherapy and chemotherapy with patient survival of 6-15 months. Read more
 Supervisors: Dr G Mavria, Dr S Bell, Dr C Toomes
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Clinical: Adherence with Cancer Treatment in Adolescents and Young Adults

University of Leeds Faculty of Medicine and Health
Adherence with therapy is a significant clinical problem in young people, for many reasons. The scale of this has never been quantified in a population-based setting. Read more
 Supervisors: Dr D Stark, Dr R Feltbower
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Genetics: Unravelling the Norrin/beta-catenin signaling pathway and its role in retinal angiogenesis and blindness

University of Leeds Faculty of Medicine and Health
Our previous work on the genetic analysis of individuals with the inherited retinal disease Familial Exudative Vitreoretinopathy (FEVR), has helped identify a new angiogenesis pathway, the Norrin/beta-catenin pathway. Read more
 Supervisors: Dr C Toomes, Dr J Bond, Dr S Bell
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Haematology: Oncogenic mechanisms causing malignant transformation of B cells and plasma cells

University of Leeds Faculty of Medicine and Health
Cancers of B cells and plasma cells, lymphomas and multiple myeloma, can be very aggressive, and often the cancer rapidly reoccurs after standard therapy. Read more
 Supervisor: Prof U Klein
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Immunotherapy: Killing Cancer using Dead Virus

University of Leeds Faculty of Medicine and Health
It is now accepted that our immune systems can hold the key to treating otherwise incurable cancers. So-called “immunotherapy” is an increasingly common method of treating tumours, leading to impressive increases in patient responses. . Read more
 Supervisors: Dr S Griffin, Dr A Samson
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Haematology: Oncogenic reprogramming of immune cells

University of Leeds Faculty of Medicine and Health
Under pathogenic challenges, cells of the innate system become epigenetically reprogrammed and establish immune memory. Read more
 Supervisors: Dr F Errington-Mais, Dr P Laslo
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Genetics: Investigating the molecular basis of optic nerve degeneration in glaucoma to try and develop a personalized medicine strategy for treatment

University of Leeds Faculty of Medicine and Health
The optic nerve is a special sensory nerve that transmits visual impulses from the retina to the brain. Primary Open Angle Glaucoma (POAG) is a chronic, progressive optic neuropathy of multifactorial origin that affects 1 in 10 elderly individuals. Read more
 Supervisor: Dr M Ali
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Genetics: Genetic studies of developmental eye disorders to investigate genotype-phenotype correlations

University of Leeds Faculty of Medicine and Health
Developmental eye defects that affect the front of the eye give rise to a spectrum of congenital ocular phenotypes that affect the cornea, lens, iris, trabecular meshwork or the globe itself. Read more
 Supervisor: Dr M Ali
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Clinical Gastroenterology: The regulation of GDH expression in Clostridioides difficile

University of Leeds Faculty of Medicine and Health
Clostridioides difficile infection (CDI), the most common cause of infective antibiotic-associated diarrhea in the western world, is diagnosed by a combination of tests that firstly detect the organism, then the toxins that it produces (Planche 2013). Read more
 Supervisors: Prof M Wilcox, Dr K Davies, Dr A Buckley
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Clinical Gastroenterology: Investigation of Fidaxomicin Resistance Mechanisms in Clostridium difficile

University of Leeds Faculty of Medicine and Health
Clostridium difficile is a leading pathogen in healthcare-associated diarrheal infections. C. difficile has a plastic genome with multiple mobile genetic elements and recognized capacity to acquire genes involved in resistance and virulence. Read more
 Supervisors: Prof M Wilcox, Prof A O'Neill, Dr J Freeman, Dr I Moura
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Cancer: Repurposing drugs as new treatments for breast cancer

University of Leeds Faculty of Medicine and Health
Breast cancer (BC) is the most common cancer, with over 1 million new cases diagnosed worldwide each year. For some types of BC, hormonal treatments have been very effective but one particular BC subtype, triple negative breast cancer (TNBC), is highly aggressive and lacks a targeted therapy. Read more
 Supervisors: Dr L Matthews, Dr P Meakin
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Cancer: Inhibiting cell metabolism to enhance tumour cell death

University of Leeds Faculty of Medicine and Health
All the cells in our bodies are programmed to die. As they get older, our cells accumulate toxic molecules that make them sick. In response, they eventually break down and die, clearing the way for new, healthy cells to grow. Read more
 Supervisors: Dr S Papa, Dr R Tooze
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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