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Biological Sciences PhD Research Projects

We have 461 Biological Sciences PhD Research Projects

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We have 461 Biological Sciences PhD Research Projects

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Antiviral innate immunity in the ASGARD archaea

  Research Group: Biomedical Sciences Research Centre
Project Description. Viruses are an important part of most environments on the planet. All living things are infected by viruses, and many different defence systems have evolved to combat infection. Read more

Examining evapotranspiration partitioning across ecosystems

Title. Examining evapotranspiration partitioning across ecosystems. Project Description. Water loss through transpiration from terrestrial ecosystems plays a crucial role in the global water cycle. Read more

Biodegradable fibres for the sustainable manufacture of antimicrobial face masks

The limited biodegradability of synthetic polymers (other than aliphatic polyesters) and the polymerisation of petroleum hydrocarbons pose inherent challenges to their long-term use. Read more

Textile Fibres from Recombinant Keratin Proteins

Applicants are invited to apply for a fully funded PhD programme to carry out a feasibility study to identify novel ways of producing recombinant keratin proteins and to produce sustainable textile fibers. Read more

Understanding the effects of immunomodulatory therapies on radiation response

Dying cancer cells are thought to be a rich source of tumour antigens and danger signals into the tumour microenvironment. Work from the Olcina lab has found that targeting complement can increase tumour cell death following radiotherapy which may in turn modulate anti-tumour immune responses. Read more

Nucleases and helicases as potential cancer targets

It is clear that the acquired genetic changes (vulnerabilities) in tumours can be exploited to treat cancer, increasingly in a manner tailored to individual patients. Read more

Investigating the role of E3 ubiquitin ligases in cancer pathogenesis

The Ubiquitin Proteasome System (UPS) is a crucial regulator of cell survival in normal conditions and after DNA damage. The function of UPS is dysregulated in cancer, thus providing a large repertoire of targets to exploit for better cancer treatment. Read more

Parallels between the biological response to viral infection and hypoxia

Regions of low oxygen or hypoxia occur in most solid tumours and predict for a poor patient outcome. Cancer cells adapt to hypoxic conditions and become resistant to therapy, therefore finding new strategies to target tumour hypoxia is essential to improve patient care. Read more

Characterisation of DNA-protein crosslink proteolysis repair in response to chemotherapy

DNA-protein crosslinks (DPCs) are under-investigated DNA lesions caused by the covalent attachment of proteins to DNA. DPCs are induced by endogenous aldehydes, chemotherapeutic drugs (such as PARP1 or Topoisomerase inhibitors) and ionising radiation. Read more

Personalised Radionuclide Theranostics for Cancer

The adoption of highly effective anticancer radiopharmaceuticals such as 223Ra, 177Lu[Lu]-PSMA and 177Lu[Lu]-DOTATAE and, in some cases, their companion imaging tracers, into oncologic practise over the last few years has invigorated the field of radiopharmaceutical therapeutics. Read more

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