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Biotechnology PhD Research Projects

We have 693 Biotechnology PhD Research Projects

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We have 693 Biotechnology PhD Research Projects

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Pharmacophylogenomics: Developing phylogenies as predictive tools in drug discovery

The Project. Drug targets are proteins encoded in our genomes that can interact with drugs, triggering physiological responses. The pairing of targets and their targeting drugs is at the core of drug discovery and is accomplished with a combination of bioinformatics and biochemical approaches. Read more

Saving Cassava : A novel gene in a deadly virus

Cassava brown streak disease (CBSD), caused by the Cassava brown streak viruses (CBSV) causes losses up to 100% and typically >60-70% of root harvest in susceptible varieties, as well as substantial losses through reducing the market value due to necrotic lesions. Read more

Redefining the metabolism of nitrogen cycling microbes using Dual Stable Isotope Probing (LEHTOVIRTA_UBIO22ARIES)

Primary Supervisor - Dr Laura Lehtovitra-Morley. Secondary Supervisor - Professor Matt Hutchings (John Innes Centre). Supervisory Team - Professor Colin Murrell (University of East Anglia, School of Environmental Sciences). Read more

Understanding the effects of immunomodulatory therapies on radiation response

Radiotherapy can ablate tumours through inducing both DNA damage and anti-tumour inflammatory responses. However, innate immunity pathways mounting inflammatory responses can also afford cell intrinsic radioresistance. Read more

The crosstalk between tumour microenvironments and MAFF to determine transcriptional activation or repression

Radiation is effective in treating many types of cancers by inducing oxidative stress through the generation of reactive oxygen species (ROS) that result in DNA damage, in particular, DNA double strand breaks (DSBs). Read more

RNA-therapeutic approaches for metabolic pathologies

  Research Group: Metabolism & Gene Regulation
Analysis of the proteome and transcriptome has demonstrated the existence of a far greater transcriptomic complexity than previously catalogued. Read more

Targeting polymerase theta as a way to improve radiotherapy and immunotherapy.

Despite technical improvements in radiation delivery, survival rates following radical radiotherapy remain poor for many tumour types and the radiation delivered to adjacent tissues is still frequently associated with significant side-effects. Read more

Ubiquitin signalling in the pathogenesis and radiotherapy of glioblastoma

Glioblastoma accounts for more than 4000 deaths every year in the UK. The cornerstone of glioblastoma treatment is constituted by maximal surgical resection, radiotherapy and chemotherapy. Read more

EASTBIO Investigating the Assembly of Bacterial Encapsulins for the Efficient Engineering of Nanoscale Bioreactors

Encapsulins are bacterial capsid-like nanocompartments roughly 25-30 nm in diameter. These large protein assemblies are made up of either 60 or 180 copies of a single 30 kDa protomers which assemble to form a hollow icosahedral protein cage. Read more

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